Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges DOI Creative Commons
Qing Huang, An Chen,

Shiyun Tang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

Diabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around world, its prevention treatment are major challenge in current community. Observational studies randomized controlled trials have revealed protective risk factors for some DN. However, conclusions these researches may be influenced by several types confounding. Mendelian randomization is new epidemiological method mainly used to infer causal relationship between exposure outcome. Many found potential relationships DN diseases lifestyle habits, thus providing valuable data future mechanistic well development implementation clinical strategies. As result, purpose this review evaluate published study DN, using bibliometric research method, analyze status hot spots, further summarize genetic evidence about protection provide inspiration etiology reference intervention.

Language: Английский

Exploring the relationship between grip strength and diabetic nephropathy among U.S. adults with type 2 diabetes mellitus: a cross-sectional NHANES analysis DOI Creative Commons
Xuebo Chen, Yi Lin,

Weisong Dong

et al.

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

To examine the relationship between grip strength (GS) and diabetic nephropathy (DN). Data on patients with type 2 diabetes mellitus collected 2011 2014 were obtained from National Health Nutrition Examination Survey (NHANES). Demographic characteristics (sex, age, race, marital status, educational level), clinical measures (smoking drinking body mass index [BMI], glycated hemoglobin [HbA1c], urinary albumin creatinine ratio [UACR], duration, hypertension), assessments collected. The GS DN was analyzed using a logistic regression model. Subgroup analyses showed as forest plots, conducted while accounting for confounding variables. Restricted cubic splines applied to investigate nonlinear correlations. A sensitivity analysis assess robustness of findings. This study included 1,539 participants. In multivariate model, odds ratios (ORs) 0.96 (95% CI, 0.94–0.98) in male 0.94 0.91–0.98) female. Compared those lowest quartiles, participants uppermost quartiles less susceptible [OR 0.35 0.20–0.62)] female 0.37 0.20–0.67)] (p trend < 0.001). After adjusting all variables, ORs 0.001) demonstrated reliable connection (all p interaction > 0.05). We discovered both nonlinearity More precisely, data revealed L-shaped inverted-S relation participants, respectively. results this cross-sectional NHANES indicated potential negative association DN. Additional extensive studies are necessary elucidate these trends.

Language: Английский

Citations

2
Assessing the causal relationship between CRP, IL-1α, IL-1β, and IL-6 levels and intervertebral disc degeneration: a two-sample Mendelian randomization study DOI Creative Commons
Xinan Yan, Erdong Shen, Aiyong Cui

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 10, 2024

Growing research has suggested an association between chronic inflammation and Intervertebral disc degeneration (IVDD), but whether there is a causal effect remains unknown. This study adopted two-sample Mendelian randomization (MR) approach to explore the etiological role of in IVDD risk. Here, summary statistics for C-reactive protein (CRP), interleukin (IL)-1

Language: Английский

Citations

2
The causal relationship of asthma to sarcopenia revealed by Mendelian randomization analysis and meta-analysis DOI Creative Commons

Haizhu Xu,

Jiajia Zhu,

Ruojing Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 29, 2024

Abstract Objectives: Sarcopenia is age-related muscle loss that results in low hand grip strength, of weight and a slow walking speed. Asthma recognized as risk factor forsarcopenia. In this study, Mendelian randomization (MR) research was utilized to detect the causal impact association asthma sarcopenia. Methods: A bidirectional two-sample MR analysis related meta-analysis were performed. To avoid influence sporadic factors, 3 datasets employed exposures. Three sarcopenia used outcomes. The inverse-variance weighted (IVW) method set primary method,and other methods auxiliary methods. Furthermore,these combined with those meta-analysis. Egger evaluate heterogeneity. Furthermore, reverse-directional conducted explore on asthma. Linkage disequilibrium score (LDSC) regression genetic associations. Results: relationship sarcopenia, there strong evidence effect appendicular lean mass using IVW yielded P value 0.0047 when first dataset. 3.82E-06 for second dataset 1.32E-05 third. 0.0001 obtained strength dataset, 4.08E-05 2.86E-05 0.0425 speed 4.23E-03 combing studies showed significant ( <0.01), <0.01). Reverse suggested exerted no onasthma. There pleiotropy study except reverse study. LDSC weak association. Conclusion: promotes development However, does not exist.

Language: Английский

Citations

0
No Genetic Causality between Branched-Chain Amino Acids and Diabetic Nephropathy: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Qiqi Ma,

Shuaihua Song,

Gaosi Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 25, 2024

Abstract Background Numerous studies have reported the close relationship between branched-chain amino acids (BCAA) and diabetic nephropathy (DN). Nevertheless, whether there is a genetically causal association them remains profoundly elusive. Methods A two-sample Mendelian randomization (MR) analysis was performed using large genome-wide of European population. The primarily evaluated by inverse variance weighted (IVW) method. In addition, MR-Egger regression, median, simple mode, MR-weighted mode were also conducted as supplemented methods. For sensitivity, Cochrane’s Q test, MR-PRESSO employed to evaluate heterogeneity pleiotropy, respectively. Results According IVW method, no significant effect measured three BCAA DN (valine: OR: 1.202, 95% CI: 0.714–2.023, P = 0.488; isoleucine: 0.878, 0.400–1.924, 0.744; leucine: 1.395, 0.686–2.839, 0.358; total BCAA: 1.374, 0.703–2.685, 0.352). reverse MR analysis, an exposure factor had on 1.004, 0.994–1.014, 0.412; 0.999, 0.990–1.009, 0.910; 1.001, 0.992–1.011, 0.802; 1.002, 0.993–1.012, 0.628). Conclusion Our results first demonstrated at genetic level.

Language: Английский

Citations

0
Assessing the causal relationship between CRP,IL-1α, IL-1β, and IL-6 levels and intervertebral discdegeneration: a two-sample Mendelianrandomization study DOI Creative Commons
Xinan Yan, Erdong Shen, Aiyong Cui

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

Abstract Growing research has suggested an association between chronic inflammation and Intervertebral disc degeneration (IVDD),but whether there is a causal effect remains unknown. This study adopted two-sample Mendelian randomization (MR) approachto explore the etiological role of in IVDD risk. Here, summary statistics for C-reactive protein (CRP),interleukin (IL)-1α, IL-1β, IL-6 expression were obtained from genome-wide studies (GWAS) Europeanancestry. MR analyses conducted by using inverse variance weighted (IVW), Wald Ratio, median, MR-Eggermethod. Sensitivity to assess robustness results. The lackof CRP, , IL-1α levels on (CRP-IVDD: odds ratio [OR] = 0.97, 95% confidence interval[CI] : 0.86-1.09, P 0.583; IL-6-IVDD: OR =1.04, CI: 0.86-1.27, 0.679; IL-1α-IVDD: OR=1.09, 95%CI 1.00-1.18,P=0.058). However, was sign connection genetically elevated IL-1β decreased IVDDincidence(OR=0.87, 95%CI: 0.77-0.99, P=0.03). Our findings suggest risk IVDD.However, due support only one SNP, heterogeneity pleiotropy tests cannot be performed, specific underlyingmechanisms warrant further investigation.

Language: Английский

Citations

0
Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction DOI Creative Commons
Jingwen Liu, Renbing Pan

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 1, 2024

Erectile dysfunction (ED) brings heavy burden to patients and society. Despite the availability of established therapies, existing medications have restricted efficacy. Therefore, we utilized a two-sample Mendelian randomization (MR) approach find drug targets that might enhance clinical outcome ED.

Language: Английский

Citations

0
Development and Validation of a Risk Prediction Model for Sarcopenia in Chinese Older Patients with Type 2 Diabetes Mellitus DOI Creative Commons
Xinming Wang,

Shengnan Gao

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 4611 - 4626

Published: Nov. 1, 2024

Sarcopenia is a common prevalent age-related disorder among older patients with type 2 diabetes mellitus (T2DM). This study aimed to develop and validate nomogram model assess the risk of incident sarcopenia T2DM. A total 1434 (≥ 60 years) diagnosed T2DM between May 2020 November 2023 were recruited. The cohort was randomly divided into training set (n = 1006) validation 428) at ratio 7:3. best-matching predictors incorporated model. accuracy applicability measured by using area under receiver operating characteristic curve (AUC), calibration curve, Hosmer-Lemeshow test, decision analysis (DCA). 571 out participants (39.8%) had sarcopenia. Nine factors, including age, body mass index (BMI), diabetic duration, glycated hemoglobin A1c (HbA1c), 25 (OH)Vitamin D, nephropathy, neuropathy, nutrition status, osteoporosis selected construct prediction AUC values for sets 0.800 (95% CI 0.773-0.828) 0.796 0.755-0.838), respectively. Furthermore, agreement predicted actual clinical probability demonstrated curves, test (P > 0.05), DCA. visual verified effectively evaluate in T2DM, allowing targeted interventions be implemented timely combat geriatric population

Language: Английский

Citations

0
Mendelian randomization analysis reveals causal factors behind diabetic nephropathy: evidence, opportunities, and challenges DOI Creative Commons
Qing Huang, An Chen,

Shiyun Tang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 13, 2024

Diabetic nephropathy (DN), as the most serious minor vascular complication of diabetes, imposes a significant socioeconomic and medical cost around world, its prevention treatment are major challenge in current community. Observational studies randomized controlled trials have revealed protective risk factors for some DN. However, conclusions these researches may be influenced by several types confounding. Mendelian randomization is new epidemiological method mainly used to infer causal relationship between exposure outcome. Many found potential relationships DN diseases lifestyle habits, thus providing valuable data future mechanistic well development implementation clinical strategies. As result, purpose this review evaluate published study DN, using bibliometric research method, analyze status hot spots, further summarize genetic evidence about protection provide inspiration etiology reference intervention.

Language: Английский

Citations

0