The impact of lactate on diabetic cognitive dysfunction: Insights from energy metabolism to epigenetic modulation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(4), P. 167749 - 167749

Published: Feb. 26, 2025

This manuscript elucidates the intricate roles of lactate in Diabetic Cognitive Dysfunction (DCD), extending beyond its conventional role as an energy substrate. The investigation centers on participation metabolism and epigenetic modulation, with a particular emphasis influence cognitive faculties through histone lactylation. discourse scrutinizes lactate's part metabolic equilibrium central nervous system, encompassing fluctuating concentrations under various conditions pivotal function within Astrocyte-Neuron Lactate Shuttle (ANLS) mechanism conduit. involvement DCD is multilayered, pathways, cellular signaling cascades, regulation gene expression. Dysregulation lactylation process may modulate neuronal functionality by impacting genes integral to neuroplasticity capabilities. These revelations offer novel insights into molecular underpinnings lay groundwork for discovery potential therapeutic targets. Subsequent scholarly endeavors are poised dissect nuanced mechanisms which exert DCD, pinpointing critical modulated assessing their ramifications signal transduction pathways. Given regulatory dynamics lactate, contingent upon concentration, temporal factors, disease etiology, more profound elucidation necessitates augmented cadre animal experimentation clinical observational research. Such investigative pursuits anticipated yield innovative approaches methodologies comprehensive management spanning prevention, diagnosis, intervention.

Language: Английский

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Risk Factors and Predictors of Cognitive Impairment in Older Adults: A Retrospective Cross-Sectional Study

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100154 - 100154

Published: April 1, 2025

Language: Английский

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Balanced Steady-State Free Precession Enables High-Resolution Dynamic 3D Deuterium Metabolic Imaging of the Human Brain at 7T

Investigative Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Objectives Deuterium ( 2 H) metabolic imaging (DMI) is an emerging magnetic resonance technique to non-invasively map human brain glucose (Glc) uptake and downstream metabolism following oral or intravenous administration of H-labeled Glc. The achievable spatial resolution limited due inherently low sensitivity DMI. This hinders potential clinical translation. purpose this study was improve the signal-to-noise ratio (SNR) 3D DMI via a balanced steady-state free precession (bSSFP) acquisition scheme combined with fast non-Cartesian spatial-spectral sampling enable high-resolution dynamic neural Glc glutamate+glutamine (Glx) synthesis at 7T. Materials Methods Six healthy volunteers (2 f/4 m) were scanned after 0.8 g/kg [6,6′]- H-Glc using novel density-weighted bSSFP concentric ring trajectory (CRT) k-space Time-resolved whole datasets acquired for approximately 80 minutes (7 per dataset) 0.75 mL 0.36 isotropic results compared conventional spoiled Free Induction Decay (FID) H-MRSI CRT readout matched nominal resolution. Dynamic measurements accompanied by simultaneous systemic interstitial fluid continuous monitoring (CGM) sensor (on upper arm). correlation between levels analyzed linear mixed models. Results bSSFP-CRT approach achieved SNRs that up 3-fold higher than FID-CRT H-MRSI. enabled 2-fold Seventy tracer comparable H-Glc, H-Glx, H-water concentrations detected both schemes both, regular high resolutions (0.75 ml isotropic). mean Areas Under Curve (AUC) obtained CGM 509 ± 65 mM·min. 3.4 times AUC 149 43 mM·min models fitted assess relationship measures yielded statistically significant slope estimates in GM (β 1 = 0.47, P 0.01) WM 0.36, 0.03). Conclusions In we successfully implemented whole-brain A SNR increase allowed us double Systemic measurements, DMI, demonstrate applications. could help our understanding linking it time-resolved peripheral levels. Importantly, these are conducted minimally invasive physiological manner.

Language: Английский

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Exercise Intervention for Alzheimer’s Disease: Unraveling Neurobiological Mechanisms and Assessing Effects

Life, Journal Year: 2023, Volume and Issue: 13(12), P. 2285 - 2285

Published: Nov. 30, 2023

Alzheimer's disease (AD) is a progressive neurodegenerative and major cause of age-related dementia, characterized by cognitive dysfunction memory impairment. The underlying causes include the accumulation beta-amyloid protein (Aβ) in brain, abnormal phosphorylation, aggregation tau within nerve cells, as well neuronal damage death. Currently, there no cure for AD with drug therapy. Non-pharmacological interventions such exercise have been widely used to treat AD, but specific molecular biological mechanisms are not understood. In this narrative review, we integrate biology summarize knowledge molecular, neural, physiological exercise-induced improvements progression. We discuss various show that directly or indirectly affects brain regulating crosstalk between peripheral organs including "bone-brain crosstalk", "muscle-brain "gut-brain crosstalk". also potential role artificial intelligence neuroimaging technologies AD. emphasize moderate-intensity, regular, long-term may improve progression through pathways, multimodal providing greater benefits. Through in-depth exploration effects improving progression, review aims contribute existing base provide insights into new therapeutic strategies managing

Language: Английский

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An Investigation of the Correlation Between Retinal Nerve Fiber Layer Thickness with Blood Biochemical Indices and Cognitive Dysfunction in Patients with Type 2 Diabetes Mellitus

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 3315 - 3323

Published: Sept. 1, 2024

The study aimed to explore the correlation between retinal nerve fiber layer thickness (RNFLT) with blood biochemical indicators and cognitive dysfunction in patients type 2 diabetes mellitus (T2DM) possible mechanism, thereby providing more theoretical basis for occurrence prevention of related complications.

Language: Английский

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