The Relationship Between Vitamin D, Cardiovascular Health, and Periodontitis in US Adults

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Background Vitamin D deficiency is a prevalent public health issue, and serum vitamin concentrations are linked to the risk of periodontitis. This study aims investigate relationship between these two variables determine whether this association influenced by various factors, particularly focusing on mediating effect cardiovascular (CVH). Methods Data was extracted from National Health Nutrition Examination Survey (NHANES) database for years 2009–2014 in cross-sectional study. The periodontitis examined using univariate multivariate logistic regression analyses, as well restricted cubic spline models. Additionally, subgroup analyses splines were employed assess effects glucose tolerance status, age, gender, smoking alcohol consumption association. Mediation analysis conducted explore LE8 scores serve mediator Results Among 12,714 adults, 4,522 (35.5%) diagnosed with periodontitis, proportions Mild, Moderate, Severe Chronic Periodontitis being 279 (2.2%), 3,438 (27.0%), 805 (6.3%), respectively. After fully adjusting confounding negative associations observed levels Quartile comparisons indicated Q2: 0.91 (0.82 ~ 1.00), Q3: 0.88 (0.79 0.99), Q4: 0.89 (0.78 1.01). In significantly associated across strata, including sex, status. Interaction revealed that age utilizing Life's Essential 8 (LE8) assessed (CVH), demonstrating score factor mediated mediation 8.71% 7.11%, Conclusion We concluded increased decreased demonstrated critical highlighted intricate interplay among D, providing insights into potential avenues intervention management.

Language: Английский

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Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 75 - 83

Published: Jan. 1, 2025

Diabetes mellitus (DM) is a chronic disease that remains global health problem with increasing prevalence, particularly in Indonesia. The presence of oral manifestations patients DM influenced by changes immune system function. Interleukin-10 (IL-10) an inflammatory marker implicated DM. However, no studies have investigated the differences IL-10 levels between non-DM and without manifestations. This study aimed to compare serum at Dr. Hasan Sadikin Hospital Bandung. observational used cross-sectional design. A total 88 samples met inclusion criteria were selected, consisting 37 (42%) from patients, 35 (39.8%) manifestations, 16 (18.2%) Serum measured using enzyme-linked immunosorbent assay (ELISA) kit. Among xerostomia was most common (80%). mean level 0.93 pg/mL 0.80 1.08 Statistical analysis Kruskal-Wallis test showed p-value 0.008 (p ≤ 0.05), indicating significant difference had lower compared These findings suggest monitoring could help identify diabetic higher risk for complications.

Language: Английский

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The Link Between Body Mass Index and Periodontitis: Unhealthy Eating Habits and Poor Oral Hygiene According to a Compelling Survey Study

Akdeniz Medical Journal, Journal Year: 2025, Volume and Issue: 11(1), P. 124 - 130

Published: Jan. 24, 2025

ABSTRACT Objective: To investigate the relationship between body mass index and periodontal diseases by conducting a comprehensive survey to assess daily eating habits self-care of oral hygiene. Material Methods: We recruited 357 patients from outpatient clinic Periodontology Department at Baskent University Hospital. All completed after their periodontological examination. The questionnaire asked about hygiene during last six months. Results: Patients with periodontitis had higher body-mass-index (BMI) than those gingivitis (26.9 ± 4.3 kg/m² vs 24.7 3.8 kg/m², respectively, p=0.000). group tea consumers (46,7% vs. 30,3%, p=0.001). coffee (17.7% %, There were more diabetic in (10.9% 2.9%, p=0.003). percentage cases was 71.4% obese patients. frequency significantly correlated BMI (Pearson correlation 0.2229, Conclusion: Individuals likely have periodontitis, consume tea, diabetes.

Language: Английский

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Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1317 - 1331

Published: Jan. 1, 2025

Periodontitis is a prevalent yet frequently overlooked oral disease that linked to range of systemic conditions. Although basic treatment and periodontal surgery can alleviate the symptoms periodontitis certain extent, severe tissue defects or refractory cases not effective. Extracellular vesicles (EVs) are subcellular lipid bilayer particles come from variety sources in biological fluids vertebrates. They play key role intercellular communication by transporting multiple signaling molecules. Recent research has indicated EVs derived pathogens trigger periodontitis, exacerbate damage, potentially disseminate other parts body, leading Conversely, extracellular dental stem cells (DSCs) have demonstrated ability regulate local immune environment foster regeneration repair tissues, positioning them as promising candidate for cell-free therapeutic approaches periodontitis. This review aims summarize latest on involvement different pathogenesis especially systematically elucidate mechanism secreted periodontitis-related diseases first time. By uncovering these complex regulatory processes, new more effective be explored battle against its associated diseases.

Language: Английский

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Transcription Factor Blimp-1: A Central Regulator of Oxidative Stress and Metabolic Reprogramming in Chronic Inflammatory Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 183 - 183

Published: Feb. 4, 2025

B-lymphocyte-induced maturation protein 1 (Blimp-1) is a transcription factor that, among other functions, modulates metabolism and helps to regulate antioxidant pathways, which important in the context of chronic inflammatory diseases like diabetes, cardiovascular disease, autoimmune disease. In immune cell function, Blimp-1 has modulatory role orchestration metabolic reprogramming as promoter anti-inflammatory cytokines, including IL-10, responsible for modulating oxidative stress homeostasis. Moreover, also key aspects, such glycolysis fatty acid oxidation, reactive oxygen species levels, well tissue protection. This review depicts an regulator defenses anti-inflammation suggests that could serve therapeutic target dysregulation conditions. The modulation diabetic coronary heart disease atherosclerosis alleviate stress, augment protection tissues, improve outcomes. potential development new treatments these conditions lies synergy between regulation therapies, are future directions may be pursued. emphasizes Blimp-1's emerging importance novel pathogenesis diseases, providing opportunities intervention.

Language: Английский

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Modulatory role of exogenous arachidonic acid in periodontitis with type 2 diabetes mellitus mice

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 19, 2025

Type 2 diabetes mellitus (T2DM) exhibits a bidirectional relationship with periodontitis, wherein each condition influences the progression of other. Arachidonic acid (AA) exerts an anti-diabetic effect, while showing protective effect by regulating inflammatory response independently its metabolites. However, impact on periodontitis T2DM remains poorly understood. The mouse model was established combining high-sugar and high-fat diet streptozotocin injection, followed silk ligation to induce periodontitis. Alterations in diabetes-associated symptoms were evaluated. Micro-computed tomography used measure bone-related parameters, including distance from cementoenamel junction alveolar bone crest, volume/total volume mineral density. Targeted metabolomics analysis conducted evaluate exogenous AA serum metabolite levels mice type diabetic 16S rRNA gene sequencing utilized analyze microbial diversity. activity osteoclasts, factors expression related osteoclasts investigated using TRAP staining real-time quantitative PCR. successfully established. Following two weeks treatment, reduction fasting blood glucose observed mice. Exogenous alleviated loss it had no substantial contents AA-targeted reduced Staphylococcus subgingival flora mice, but significant community structure or Furthermore, decreased number increased IL-10 mRNA gingival tissue. may alleviate reducing increasing periodontal tissues, rather than change metabolites composition diversity microorganisms plaque. These findings provide potential therapeutic approach for prevention treatment T2DM.

Language: Английский

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An Artificial Intelligence-Based Fuzzy Logic System for Periodontitis Risk Assessment in Patients with Type 2 Diabetes Mellitus

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 211 - 211

Published: Feb. 20, 2025

Background: Since periodontitis prevalence has increased globally and there is a bidirectional relationship between diabetes mellitus (DM), new methods of preventing screening involving DM biomarkers could impact management. We aimed to develop fuzzy system estimate the risk in patients with DM. Methods: Body mass index (BMI), glycemia (G), total cholesterol (C), triglyceride (T) measurements were collected from 87 diagnosed Oral examinations performed, number periodontal pockets (nrPPs) was determined. A developed: BMI G as inputs resulted Periodontitis Risk 1 (PRisk1) output; C T 2 (PRisk2) output. From PRisk1 PRisk2, cumulative (PCRisk) assessed. Linguistic terms linguistic grades (very small, medium, big, very big) assigned numerical variables by using 25 different membership functions. PCRisk nrPP values statistically processed. Results: In our developed system, BMI, G, C, input data estimation. correlated nrPP: when 1.881 units, unit. The logic-based effectively estimated type patients, showing significant correlation pockets. These findings highlight its potential for early diagnosis improved interdisciplinary care.

Language: Английский

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The need for effective interprofessional collaboration between nutrition and dentistry

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

There are bidirectional relationships between diet and nutrition, systemic health oral health. Diet nutrition fundamental to the prevention management of chronic diseases. Systemic can impact And influence nutrition. The 2020 Surgeon General's Report "Oral Health in America" stated that is an integral factor development disease overall. Within medical model, Registered Dietitians have been impactful members a multidisciplinary team by providing therapy nutritional counseling reduce diseases like obesity, diabetes cardiovascular disease. Despite well-established collaboration role plays outcomes, there limited documented dentistry. purpose this paper review current evidence settings compared identify specific challenges, suggest possible next steps for collaboration. intended outcome will be provide reader with insight about need integrate into both education clinical practice address prevalent increase equity those at high risk.

Language: Английский

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Estimation of Salivary Creatine Kinase Level and Periodontal Health Status among Type II Diabetic and Nondiabetic Patients with Chronic Periodontitis

European Journal of General Dentistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract Objectives This study was conducted to determine the periodontal health status and level of creatine kinase (CK) control groups correlate this enzyme with clinical parameters in groups. Materials Methods included 80 male participants aged 35 55 years, divided into four groups: poorly controlled type 2 diabetes mellitus chronic periodontitis (G1), well-controlled (G2), without (G3), periodontally healthy controls (G4). Clinical (plaque index, gingival pocket depth [PPD], attachment loss) salivary CK levels (measured using enzyme-linked immunosorbent assay) were compared between Results All highest patients, revealed highly significant differences all pairs There nonsignificant weak correlations except a moderate positive correlation PPD nondiabetic group. Conclusion It concluded that poor glycemic negatively impacts status. is considered good biochemical marker tissue destruction useful diagnosis, monitoring, management diseases.

Language: Английский

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γ-Mangostin mitigates impaired wound healing and pyroptosis in human gingival fibroblasts induced by advanced glycation end products

Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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