International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139194 - 139194
Published: Dec. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: March 5, 2024
Background: Alchornea laxiflora (Benth.) Pax & K. Hoffm. (A. laxiflora) has been indicated in traditional medicine to treat depression. However, scientific rationalization is still lacking. Hence, this study aimed investigate the antidepressant potential of A. using network pharmacology and molecular docking analysis. Materials methods: The active compounds targets depression-related were retrieved from public databases, such as PubMed, PubChem, DisGeNET, GeneCards, OMIM, SwissTargetprediction, BindingDB, STRING, DAVID. Essential bioactive compounds, targets, signaling pathways predicted silico analysis, including BA-TAR, PPI, BA-TAR-PATH construction, GO KEGG pathway enrichment Later on, with interaction essential core depression verified. Results: approach identified 15 a total 219 compound-related 14,574 200 intersecting between them. SRC, EGFR, PIK3R1, AKT1, MAPK1 whereas 3-acetyloleanolic acid 3-acetylursolic most anti-depressant potential. functional analysis revealed 129 terms, 82 biological processes, 14 cellular components, 34 function terms. yielded significantly enriched 108 pathways. Out them, PI3K-Akt MAPK might have key role treating Molecular results exhibited that depression, MAPK1, bind stably analyzed laxiflora. Conclusion: present elucidates pertinent mechanism action . exert an effect by regulating further investigations are required validate.
Language: Английский
Citations
15
Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 740 - 740
Published: March 26, 2024
The human gastrointestinal tract houses a diverse range of microbial species that play an integral part in many biological functions. Several preclinical studies using germ-free mice models have demonstrated the gut microbiome profoundly influences carcinogenesis and progression. Colorectal cancer appears to be associated with dysbiosis involving certain bacterial species, including F. nucleatum, pks+ E. coli, B. fragilis, virome commensals also disrupted patients. A toward these pro-carcinogenic increases significantly CRC patients, reduced numbers preventative Clostridium butyicum, Roseburia, Bifidobacterium evident. There is correlation between infection CRC. particular, strongly where it therapeutic resistance poor outcomes carcinogenic mode action pathogenic bacteria result genotoxicity, epigenetic alterations, ROS generation, pro-inflammatory activity. aim this review discuss their impact on colorectal terms disease initiation, progression, metastasis. potential anticancer peptides as agents or adjuvants discussed, novel treatment options are required combat high levels current pharmaceutical options.
Language: Английский
Citations
11
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 752 - 752
Published: Feb. 22, 2025
Altered levels of reactive oxygen species (ROS) are recognized as one the key factors in mediating tumor cell survival tissue microenvironment, where they play a role initiation, progression and recurrence/relapse colorectal cancer (CRC). Tumor cells can adapt to oxidative stress (OS) using genetic or metabolic reprogramming long short term. In addition, defend themselves through positive regulation antioxidant molecules, enhancing ROS-driven proliferation. Balanced eustress influence chemotherapy resistance, allowing survive treatment. Secondary effects include increased ROS production redox stress, which kill eliminate drug resistance. Anticancer treatments based on manipulating could represent gold standard CRC therapy. Therefore, exploring modulation response OS deregulated signaling pathways may lead development new personalized overcome therapy this review, we explore initiation their diagnostic implications biomarkers disease. Furthermore, focused involvement different therapeutic options, such surgery, radiotherapy, theranostic imaging, immunotherapy other precision medicine approaches.
Language: Английский
Citations
2
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 227, P. 116456 - 116456
Published: July 28, 2024
Furanodienone, a biologically active constituent of sesquiterpenes isolated from Rhizome Curcumae, has been reported to induce apoptosis in human colorectal cancer (CRC) cells by promoting the generation reactive oxygen species (ROS). However, source ROS and how it manipulates CRC remains be elucidated. Herein, we assessed potential role well-known sources intracellular ROS-mitochondrial electron transport chain nicotinamide adenine dinucleotide phosphate oxidases (NOXs), on furanodienone-induced cell death. The results indicated that furanodienone substantially increased levels mitochondrial ROS, which were subsequently eliminated general NOX inhibitor. Specifically, nuclear factor kappa-B (NF-κB) translocation triggered significant rise expression NOX4, an isoform NOXs family, upon treatment. Nevertheless, specific NOX4 inhibitor GLX351322 attenuated production. As result, burst induced suppressed peroxiredoxin1 (PRDX1), redox signaling protein overexpressed cells, through factor-erythroid-2-related 2 (Nrf2)-dependent pathway, thus amplifying mitogen-activated kinases (MAPKs)/p53-mediated apoptotic increasing p-p38, p-JNK levels, as well cleaved caspases -3, -8 -9. In vivo experiments further confirmed anti-proliferative impact PRDX1 following summary, study demonstrated is initiated derived targeted activated downstream MAPKs/p53-mediated caspase-dependent pathway. Our findings may provide novel insights into development adjuvant drugs for treatment therapeutic applications.
Language: Английский
Citations
8
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 508 - 508
Published: March 31, 2025
Background: Alchornea laxiflora (Benth.) Pax & K. Hoffm. (A. laxiflora) is utilized as a traditional herb for treating several diseases. Objective: Our study aims to identify the active phytochemical candidates from A. and analyses predict their anticancer activity mechanism by employing network pharmacology, molecular docking, dynamics (MD). Methods: The phytoconstituents of were retrieved literature, phytoconstituent-related targets implicated in hepatocellular carcinoma (HCC) collected respective databases. Computational methods employed recognize essential compounds, hub gene targets, signaling pathways. Results: has identified 12 potentially bioactive 150 potential anti-HCC 15 laxiflora. Molecular docking results recognized better binding energy values below −5.6 kcal/mol. Further, MD simulations three top-scoring protein–ligand complexes (MAPK—3-acetylursolic acid, AKT1—quercetin, AKT1—3-acetylursolic acid) allowed us validate results, evaluate stability complexes, associated conformational changes. Conclusions: research claims that are crucial liver cancer, protein can serve biomarkers, respectively.
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1358 - 1358
Published: April 16, 2025
Background. Worldwide, colorectal cancer is the third most commonly diagnosed cancer. It second leading cause of cancer-related mortality. Recent studies establish a relationship between natural compounds from plants with prevention and treatment Specifically, glucosinolates antitumoral capacity polyphenols ability to scavenge free radicals that can cell damage have been identified in Brassicaceae family. Objectives. Based on previously mentioned factors, this study aimed develop nutraceutical made extracts different seeds its antioxidant antiproliferative action vitro vivo using AOM/DSS model CC57BL6J mice. Results. Extract Eruca sativa Sinapis alba showed highest among species studied were selected for formulation, which was potentially absorbable (73%) after an digestion process. In total, thirty could be responsible tumoral capacity. The intake successful intervention prevent development polyps by 31.6% their size 53.9%. When nutritional used combination physical exercise protocol, these parameters dropped 52.3% 62.6%, respectively. Conclusions. These findings suggest consumption diet rich bioactive Brassica species, activity, valuable strategy However, more research required evaluate efficacy safety interventions clinical settings.
Language: Английский
Citations
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9449 - 9474
Published: July 11, 2024
Language: Английский
Citations
5
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122935 - 122935
Published: Nov. 4, 2024
Language: Английский
Citations
5
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 163, P. 112337 - 112337
Published: March 22, 2024
Language: Английский
Citations
4
Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Language: Английский
Citations
0