Reaction Kinetics Mechanisms and Catalysis, Journal Year: 2023, Volume and Issue: 137(1), P. 39 - 51
Published: Nov. 15, 2023
Language: Английский
The Open Medicinal Chemistry Journal, Journal Year: 2025, Volume and Issue: 19(1)
Published: April 24, 2025
Oxidative stress plays a crucial role in the pathophysiology of numerous diseases, including cardiovascular disorders, diabetes, neurodegenerative conditions, and chronic kidney disease. Reactive oxygen species (ROS) reactive nitrogen (RNS) are key contributors to cellular damage through oxidative nitrosative stress, affecting processes such as apoptosis, inflammation, fibrosis. This review explores molecular mechanisms underlying its connection various enzymatic non-enzymatic antioxidants counteracting harmful effects. Emerging therapeutic strategies, Nrf2 activators mitochondria-targeted antioxidants, highlighted promising tools for disease prevention treatment. Understanding interplay between progression can pave way precision medicine approaches, offering more personalized effective treatments.
Language: Английский
Citations
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Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: May 15, 2025
Background Given the complexity of pathological mechanisms behind Alzheimer’s disease (AD), there is a pressing need for novel multi-targeting therapeutic agents. Astaxanthin, natural compound with diverse biological effects, has emerged as potential candidate in neuronal diseases. Purpose This study aimed to evaluate neuroprotective effects astaxanthin scopolamine-induced rat model AD. Materials and methods In total, 36 male Wistar rats were divided into six groups, including control group receiving normal saline, negative treated scopolamine (1 mg/kg), two groups at doses 5 10 mg/kg. Additionally, pre-treated naloxone (0.1 mg/kg) or flumazenil (0.5 block opioid benzodiazepine receptors, respectively, followed by most effective dose (i.e., mg/kg). Treatments administered via intraperitoneal injection 14 consecutive days behavioral tests done. Biochemical analyses, zymography, Western blotting, histopathological examinations also performed. Results discussion Astaxanthin treatment significantly improved cognitive function, enhanced plasma antioxidant capacity increasing catalase glutathione levels, reduced nitrite levels. It increased serum activity matrix metalloproteinase 2 (MMP-2), while decreasing MMP-9, expression nuclear factor erythroid 2–related (Nrf-2) kappa B (NF-κB) hippocampal tissue. Histopathological findings indicated damage after administration. The aforementioned protective reversed flumazenil. Conclusion demonstrates against AD through its neuroprotective, antioxidant, anti-inflammatory properties, potentially involving interactions receptors.
Language: Английский
Citations
0
Published: Feb. 5, 2024
The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM's beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.
Language: Английский
Citations
1
Toxicology Research, Journal Year: 2024, Volume and Issue: 13(3)
Published: May 1, 2024
Abstract The protein, Nuclear factor-E2-related factor 2 (Nrf2), is a transitory protein that acts as transcription and involved in the regulation of many cytoprotective genes linked to xenobiotic metabolism antioxidant responses. Based on existing clinical experimental data, it can be inferred neurodegenerative diseases are characterized by an excessive presence markers oxidative stress (OS) reduced defense systems both brain peripheral tissues. imbalances homeostasis between oxidants antioxidants has been recognized substantial pathogenesis disorders. dysregulations include several cellular processes such mitochondrial failure, misfolding, neuroinflammation. These all contribute disruption proteostasis neuronal cells, leading their eventual mortality. A noteworthy component Nrf2, shown recent research undertaken over last decade, its role development resistance OS. Nrf2 plays pivotal regulating defend against Extant offers substantiation for protective defensive roles context diseases. purpose this study provide comprehensive analysis influence OS function within realm Furthermore, we evaluate most academic inquiries empirical evidence about beneficial potential certain activator compounds therapeutic interventions.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12311 - 12311
Published: Nov. 16, 2024
Alzheimer's disease (AD) is a global health concern and the leading cause of dementia in elderly. The prevalence this neurodegenerative condition projected to increase concomitantly with increased life expectancy, resulting significant economic burden. With very few FDA-approved disease-modifying drugs available for AD, there an urgent need develop new compounds capable impeding progression disease. Given unclear etiopathogenesis review emphasizes underlying mechanisms condition. It explores not only well-studied aspects, such as accumulation Aβ plaques neurofibrillary tangles, but also novel areas, including glymphatic lymphatic pathways, microbiota gut-brain axis, serotoninergic autophagy alterations, vascular dysfunction, metal hypothesis, olfactory pathway, oral health. Furthermore, potential molecular targets arising from all these have been reviewed, along promising approaches nanoparticle-based therapy, neural stem cell transplantation, vaccines, CRISPR-Cas9-mediated genome editing techniques. Taking into account overlap various mechanisms, individual combination therapies emerge future direction AD strategy.
Language: Английский
Citations
1
Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2023, Volume and Issue: 235, P. 115674 - 115674
Published: Aug. 21, 2023
Several natural remedies are used in the Traditional Persian Medicine (TPM) to prevent dementia, but their efficacy is debated. In this work, an improved "Safoof-e-Nesyān" formulation described "Qarābādin-e-Azam" pharmacopoeia was developed, and its chemical composition antioxidant anti-cholinesterase properties were assessed. The contains a mixture (FM) of Cinnamomum cassia (CC), C. verum (CV), Pistacia lentiscus (PL), Rheum palmatum (RP), Syzygium aromaticum (SA), Zingiber officinalis (ZO) powdered plants. Its total phenolic content 110.45 mg GAE/g, while flavonoid 6.28 RE/g. 66 secondary metabolites (mainly tannins, flavonoids, anthraquinones, gingerols) identified by UPLC-QToF-MS analysis. FM exerts effects scavenging radicals, reducing chelating metals such as Mb, Cu Fe. anticholinesterase activity one gram equals that 3.60 reference drug galantamine, on both acetyl- butyryl-cholinesterase. Correlations between specific compounds bioactivities highlighted multivariate analysis data: lyoniresinol 9'-glucoside strongly correlates with antiradical activities DPPH ABTS Cu, anti-AChE effects. Most flavonoids ellagic acid derivatives positively correlate Fe anti-BChE Finally, tablet physical preliminarily Overall, our results indicate may be useful remedy for although further safety assessments vivo required.
Language: Английский
Citations
1
Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1805 - 1805
Published: Nov. 3, 2024
Background and Objectives: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in world. Due to failure of traditional drugs produce a complete cure for AD, search new safe effective lines therapy has attracted attention ongoing research. Canagliflozin an anti-diabetic agent with proven efficacy treatment neurological disorders which mitochondrial dysfunction, oxidative stress, apoptosis, autophagy play pathophysiological role. Elucidation potential effects different doses canagliflozin on AD induced by aluminium chloride rats exploration molecular mechanisms that may contribute these were primary objectives current study. Materials Methods: In rat model effect three behavioural, biochemical, histopathological alterations was assessed. Results: administered chloride-treated animals dose-dependent normalisation behavioural tests, augmentation antioxidant defence mechanisms, inhibition TXNIP/NLRP3 inflammasome signalling, modulation SIRT1/HMGB1 axis, interference pro-inflammatory pro-apoptotic restoration functions hippocampal tissues approximately baseline values. addition, exhibited interesting ability repress chloride-induced changes brain. Conclusions: The functions, inflammatory pathways, signals open gates towards mitigation pathologic features AD.
Language: Английский
Citations
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Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 26, 2024
To explore the molecular mechanism of Sijunzi Decoction (SJZD) in treatment Parkinson's disease (PD) through application network pharmacology, docking, and dynamics simulations, complemented by experimental verification.
Language: Английский
Citations
0
Reaction Kinetics Mechanisms and Catalysis, Journal Year: 2023, Volume and Issue: 137(1), P. 39 - 51
Published: Nov. 15, 2023
Language: Английский
Citations
0