Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Autophagy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12
Published: June 14, 2024
Macroautophagy/autophagy is an essential degradation process that removes abnormal cellular components, maintains homeostasis within cells, and provides nutrition during starvation. Activated autophagy enhances cell survival stressful conditions, although overactivation of triggers induction autophagic death. Therefore, early-onset promotes whereas late-onset provokes programmed death, which can prevent disease progression. Moreover, regulates pancreatic β-cell functions by different mechanisms, the precise role in type 2 diabetes (T2D) not completely understood. Consequently, this mini-review discusses protective harmful roles β pathophysiology T2D.
Language: Английский
Citations
9
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115674 - 115674
Published: Nov. 1, 2023
The incidence of diabetes mellitus (DM) is gradually increasing, making it a widespread global health concern. Cadmium (Cd) common toxic heavy metal in the environment, and cadmium exposure may be associated with diabetic nephropathy (DN). However, mechanism Cd-induced DN remains unclear. In this study, we aimed to determine effect on kidney injury underlying rats renal tubular epithelial cell line (NRK-52E cells). Our results could provide novel insights nephrotoxic cadmium. HE, PAS, Masson staining were used observe pathological injury. COL-I, COL-IV, CTSB, CTSD protein levels detected by immunohistochemistry western blotting. Immunofluorescence was detect fluorescence intensity p62 LC3 proteins tissue. TEM ultrastructure mitochondria number autophagosomes. After exposure, DM showed dramatic decrease body weight compared unexposed group. Relative contrasting trend after exposure. Urinary microalbumin/creatinine significantly increased normal clearer groups than control groups. Endogenous creatinine clearance exhibited trend. rats, MDA content GSH, CAT, SOD, GSH-PX activation reduced controls. Pathological damage more pronounced, expression autophagy related apoptosis fibrosis higher vivo vitro cadmium-exposed Further, lysosomal lower, ROS autophagosome count exposed Therefore, aggravates via inhibition.
Language: Английский
Citations
14
Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 220 - 220
Published: Jan. 10, 2024
Type 2 diabetic osteoporosis (T2DOP) is a common complication in patients that seriously affects their health and quality of life. The pathogenesis T2DOP complex, there are no targeted governance means modern medicine. Citri Reticulatae Pericarpium (CRP) traditional Chinese medicine has long history been used the treatment diseases. However, molecular mechanism for CRP not clear. Therefore, this study aimed to explore underlying mechanisms by using network pharmacology modeling techniques. By retrieving multiple databases, we obtained 5 bioactive compounds 63 targets with T2DOP, identified AKT 1, TP 53, JUN, BCL 2, MAPK NFKB ESR 1 as core PPI network. Enrichment analysis revealed these were mainly enriched estrogen signaling pathway, TNF AGE-RAGE pathway diabetics, which related oxidative stress hormonal regulation. Molecular docking dynamics simulations have shown excellent binding effect targets. These findings reveal may ameliorate through multicomponent multitarget pathways.
Language: Английский
Citations
6
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(29), P. 16204 - 16220
Published: July 10, 2024
The term type 3 diabetes mellitus (T3DM) has been considered for Alzheimer's disease (AD) due to the common molecular and cellular characteristics found between 2 (T2DM) cognitive deficits. However, specific mechanism of T3DM remains elusive, especially neuroprotective effects dietary components in hyperglycemic individuals. In this study, a peptide, Leu-Val-Arg-Leu (LVRL), walnuts significantly improved memory decline streptozotocin (STZ)- high-fat-diet (HFD)-stimulated T2DM mouse models (
Language: Английский
Citations
4
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 981, P. 176856 - 176856
Published: July 27, 2024
Language: Английский
Citations
4
Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114478 - 114478
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Cell Death, Journal Year: 2025, Volume and Issue: 4
Published: March 19, 2025
When yeast cells are transferred to water only, they remain viable for several days. However, when with glucose, there is a rapid loss of viability. This phenomenon termed Sugar-Induced Cell Death (SICD). In addition SICD can be induced by an array different sugars and thought triggered increased levels intracellular reactive oxygen species (ROS) generated upon transfer sugar-only solutions. Although not SICD, similar response observed in mammalian cells, whereby high glucose induces cell death, especially cases hyperglycemia diabetes. contrast, cancer thrive under conditions glucose. this review, we summarize the current understanding highlight studies showing presence High Glucose-Induced (HGICD). We end discussion on mechanisms which evade HGICD. Unlike other types death yeast, has yet been thoroughly reviewed. Therefore, review represents first comprehensive comparison HGICD eukaryotes.
Language: Английский
Citations
0
Human Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 200313 - 200313
Published: April 1, 2025
Language: Английский
Citations
0
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: April 24, 2025
Abstract Diabetic neuropathy (DN) is a prevalent and debilitating complication of diabetes mellitus, significantly impacting patient quality life contributing to morbidity mortality. Affecting approximately 50% patients with diabetes, DN predominantly characterized by distal symmetric polyneuropathy, leading sensory loss, pain, motor dysfunction, often resulting in diabetic foot ulcers lower-limb amputations. The pathogenesis multifaceted, involving hyperglycemia, dyslipidemia, oxidative stress, mitochondrial inflammation, which collectively damage peripheral nerves. Despite extensive research, disease-modifying treatments remain elusive, current management primarily focusing on symptom control. This review explores the complex mechanisms underlying highlights recent advances diagnostic therapeutic strategies. Emerging insights into molecular cellular pathways have unveiled potential targets for intervention, including neuroprotective agents, gene stem cell therapies, innovative pharmacological approaches. Additionally, novel tools, such as corneal confocal microscopy biomarker-based tests, improved early detection intervention. Lifestyle modifications multidisciplinary care strategies can enhance outcomes. While significant progress has been made, further research required develop therapies that effectively halt or reverse disease progression, ultimately improving lives individuals DN. provides comprehensive overview understanding future directions management.
Language: Английский
Citations
0
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: April 18, 2024
Numerous studies have reported a high incidence and risk of severe illness due to coronavirus disease 2019 (COVID-19) in patients with type 2 diabetes (T2DM). COVID-19 may experience elevated or decreased blood sugar levels even develop diabetes. However, the molecular mechanisms linking these two diseases remain unclear. This study aimed identify common genes pathways between T2DM COVID-19.
Language: Английский
Citations
3