Inverse U-shaped association between weight-adjusted waist index and femur bone mineral density in the older adults:NHANES 2005-2018 DOI Creative Commons
Jun Wang, Xin Lv, Jianjun Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract The weight-adjusted waist Index (WWI) emerges as a novel metric for assessing obesity. aim of this research was to explore the association between WWI and total femoral Bone Mineral Density (BMD) in older adults United States. This study involving individuals aged 60 years utilized data from National Health Nutrition Examination Survey (NHANES) across five survey cycles (from 2005–2010, 2013–2014, 2017–2018) examine femur BMD. In research, we employed suite statistical methods both linear nonlinear associations. Additionally, threshold effect analysis conducted ascertain saturation WWI. Analysis via multivariate regression uncovered notably positive correlation BMD among 7292 US seniors [β: 0.0138, 95% CI: (0.0069, 0.0206), P: 0.0003]. Consistent correlations were observed various demographic subgroups. Furthermore, smooth curve fitting ,an inverse U-shaped identified BMD.And analysis, critical inflection point established at 11.93 cm/√kg. So, an adults,and maintaining certain level may have protective on

Language: Английский

Regulation of osteoclast-mediated bone resorption by lipids DOI

Fang Luo,

Tianyi Chen, Song Chen

et al.

Bone, Journal Year: 2025, Volume and Issue: 193, P. 117423 - 117423

Published: Feb. 9, 2025

Language: Английский

Citations

1
Lipid accumulation product index is a risk factor for osteoporosis in elderly patients with type 2 diabetes mellitus DOI
Pingping Zhao, Dengrong Ma, Xiaohui Zan

et al.

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

1
Association of a body shape index with femur bone mineral density among older adults: NHANES 2007–2018 DOI

Mengyuan Zhang,

Yue Hou, Xiaohe Ren

et al.

Archives of Osteoporosis, Journal Year: 2024, Volume and Issue: 19(1)

Published: July 22, 2024

Language: Английский

Citations

6
Association Between Osteoporosis and Adiposity Index Reveals Nonlinearity Among Postmenopausal Women and Linearity Among Men Aged over 50 Years DOI Creative Commons
Po‐Ju Chen, Yueh‐Chien Lu, Sheng‐Nan Lu

et al.

Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 14(3), P. 1202 - 1218

Published: July 24, 2024

Abstract Purpose Previous research shows conflicting views on the relationship between obesity and osteoporosis, partly due to variations in classification nonlinear nature of these relationships. This study investigated association adiposity indices diagnosed using dual-energy X-ray absorptiometry (DXA), employing models offering optimal thresholds prevent further bone mineral density decline. Methods In 2019, a prospective enrolled males over 50 years postmenopausal women. Anthropometric measurements, blood biochemistry, osteoporosis measured by DXA were collected. Associations analyzed generalized additive model segmented regression model. Results The included 872 women 1321 men. Indices such as abdominal volume index (AVI), visceral (VAI), waist circumference (WC), hip circumference, body mass (BMI), waist-to-hip ratio, waist-to-height ratio (WHtR) inversely associated with osteoporosis. women, risk was U-shaped, WC = 94 cm, AVI 17.67 cm 2 , BMI 25.74 kg/m VAI 4.29, WHtR 0.61, considering changes density. Conversely, men exhibited linear patterns for inverse association. Conclusion impact varies significantly is (U-shaped), both very low high linked higher risk. 50, linear, lower suggests that maintaining specific levels could help

Language: Английский

Citations

6
Association between physical activity energy expenditure and bone mineral density in U.S. adults: A cross-sectional analysis of NHANES 2011–2018 DOI
Rui Chen, Senlin Wang, Linke Li

et al.

Public Health, Journal Year: 2025, Volume and Issue: 240, P. 195 - 202

Published: Feb. 7, 2025

Language: Английский

Citations

0
Association of the Chinese visceral adiposity index with marrow adiposity in postmenopausal females DOI Creative Commons

Xiaoyong Zuo,

Zeyang Miao,

Run Xu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

To investigate the relationship between Chinese visceral adiposity index (CVAI) and vertebral proton density fat fraction (PDFF). The study included 181 postmenopausal females including 53 normal bone mineral (BMD), 88 osteopenia, 40 osteoporosis. Vertebral marrow PDFF was measured using Fat Analysis & Calculation Technique imaging, BMD assessed via dual-energy X-ray absorptiometry. Bone turnover biomarkers lipid metabolism were evaluated. CVAI multivariable linear regression models, generalized additive threshold effect analysis. mean at lumbar spine increased, significantly decreased as quartiles of increased (P for trends <0.05). Multivariable analysis revealed a clear negative correlation (regression coefficient β = -0.251, 95% CI, -0.303 to -0.200; P < 0.001) after adjusting age, time since menopause, waist circumference, body mass index, physical activity, profiles. association with remained significant (β -0.202, -0.255 -0.149, even additional adjustment BMD. Further an L-shaped non-linear profiles, An inflection point identified 128.3, below which each one-unit increase in corresponded more substantial decrease -0.0055, CI: -0.0064 -0.0045; 0.001). However, above this point, unit not associated PDFF. exhibited nonlinear within suitable range, once crossed definite threshold, ceased increase. This finding suggests that moderate accumulation may enhance skeletal integrity, while excessive could potentially have detrimental effects.

Language: Английский

Citations

0
Association between plain water intake and the risk of osteoporosis among middle-aged and elderly people in the United States: a cross-sectional study DOI Creative Commons
Xudong Wang, Meng Wang, Zijian Guo

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 18, 2025

The connection between plain water intake (PWI) and osteoporosis risk is still unclear. investigation aimed to identify the relationship PWI in middle-aged elderly individuals United States (US). This cross-sectional study was conducted among participants aged 50 years older following waves of National Health Nutrition Examination Survey (NHANES): 2007-2008, 2009-2010, 2013-2014, 2017-2018. examined by multivariable logistic regression models, accompanied subgroup analyses interaction tests. Smooth curve fitting threshold effect analysis were utilized. present included 6,686 participants. In accordance with fully adjusted model, highest tertile had a significantly reduced contrast those lowest [odds ratio (OR) = 0.62; 95% confidence interval (CI): 0.49-0.77; P for trend<0.001]. After adjusting all covariates, higher linked decreased (OR 0.92; CI: 0.86-0.98; p 0.008). No significant interactions detected age, gender, race, body mass index, diabetic history, hypertension status, smoking consumption prednisone or cortisone, moderate strenuous activity (all interaction>0.05). revealed that when less than 1,220 mL/day, there negative 0.79; 0.70-0.89; < 0.001); nevertheless association not greater mL/day 1.06; 0.95-1.17; 0.288). outcomes our indicated US adults, connected moderately risk. Managing might reduce

Language: Английский

Citations

0
The association between lipid accumulation product and osteoporosis in American adults: analysis from NHANES dataset DOI Creative Commons

Huawen Pan,

Xiao Long, Ping Wu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

Background The Lipid Accumulation Product (LAP), a novel indicator of fat accumulation, reflects the distribution and metabolic status body fat. This study aims to evaluate relationship between adult Americans’ prevalence osteoporosis LAP. Methods used data from NHANES cycles 2007–2010, 2013–2014, 2017–2018, including 4,200 adults aged 50 above. LAP was calculated using waist circumference triglyceride levels, whereas identified information dual-energy X-ray absorptiometry (DXA) assessments bone mineral density (BMD). Restricted cubic spline (RCS) analysis evaluated osteoporosis. Additionally, subgroup analyses were conducted assess impact demographic characteristics health on Results shown be significantly inversely correlated in study. In unadjusted model, Log showed significant negative connection (OR = 0.62, 95% CI 0.52–0.74). Osteoporosis decreased by 45% fully adjusted model for every unit rise 0.54, 0.44–0.66). RCS revealed nonlinear association ( P -non-linear 0.0025), showing an L-shaped correlation. Subgroup studies that, regardless age, sex, ethnicity, or condition, there constant Conclusion According this study, is substantial America easy-to-use practical indication that may very helpful prevention early detection.

Language: Английский

Citations

0
The mediating role of BMI in the relationship between OSAHS and bone metabolism in male patients with T2DM DOI
Ling Ding,

Xiaohong Jiang

Sleep And Breathing, Journal Year: 2025, Volume and Issue: 29(2)

Published: April 12, 2025

Language: Английский

Citations

0
Association of type 2 Diabetes Mellitus and bone mineral density: a two-sample Mendelian randomization study DOI Creative Commons
Jianbin Guan, Tao Liu, Hao Chen

et al.

BMC Musculoskeletal Disorders, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 12, 2024

Abstract Background Observational studies have suggested that type 2 Diabetes Mellitus (DM2) is a potentially modifiable risk factor for lower BMD, but the causal relationship unclear. This study aimed to examine whether association of DM2 with BMD levels was by using Mendelian randomization (MR) analyses. Methods We collected genome-wide data and total body different skeletal sites from IEU database. Subsequently, we performed two-sample analysis Two Sample MR package. Results identified positive between (61,714 cases 596,424 controls) other such as femoral neck ultra-distal forearm heel BMD. However, non-significant trends were observed effects on lumbar-spine Conclusion In analyses, there in both overall samples. summary, while observational analyses consistently indicate strong low our introduces nuanced perspective. Contrary robust studies, suggests significant link elevated

Language: Английский

Citations

4