Estrogen, estrogen receptor and the tumor microenvironment of NSCLC

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Lung cancer remains the foremost cause of cancer‐related mortality worldwide. Clinical observations reveal a notable increase in both proportion and rate among female non‐small cell lung (NSCLC) patients compared to males, trend that continues escalate. Extensive preclinical research underscores pivotal role estrogen initiation, progression, prognosis, treatment response NSCLC. Estrogen receptors are widely expressed stromal immune cells, influencing cellular activities across innate adaptive systems. Immune evasion mechanisms significantly impact tumor development outcomes, with immunotherapy offering promise NSCLC by targeting these mechanisms. The intriguing gender disparities responses prompt an exploration into data on occurrence, gender‐specific immunotherapy. Evidence highlights estrogen's contribution tumor‐permissive microenvironment, various cells including cancer‐associated fibroblasts, macrophages, neutrophils, dendritic natural killer B T cells. Gender‐specific variations development, efficacy likely stem from interactions between estrogen, estrogen‐responsive shaping microenvironment conducive progression. Clarifying its signaling pathways may unveil novel therapeutic strategies modify or enhance efficacy.

Language: Английский

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Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non‐responders

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(5)

Published: May 1, 2024

Abstract Background The gut is an important site for human immunodeficiency virus (HIV) infection and immune responses. role of mucosal cells in restoration patients infected with HIV undergoing antiretroviral therapy remains unclear. Methods Ileocytes, including 54 475 cells, were obtained from colonoscopic biopsies five HIV‐negative controls, nine immunological responders (IRs), three non‐responders (INRs) analyzed using single‐cell RNA sequencing. Immunohistochemical assays performed validation. 16S rRNA gene was amplified PCR faecal samples to analyze microbiota. Flow cytometry used CD4+ T‐cell counts the activation T cells. Results This study presents a global transcriptomic profile HIV. Compared IRs, INRs exhibited lower proportion plasma especially IGKC + IgA cell subpopulation. negatively associated enriched f. Prevotellaceae correlated overactivation but they positively CD4 counts. higher B than IRs. Follicular memory significantly INRs. Reduced potential observed differentiation follicular or into In addition, receptor‐ligand pairs CD74_MIF CD74_COPA B/ helper reduced INRs, which may hinder Conclusions Our shows that are dysregulated provides extensive resource deciphering pathogenesis Key points An investigation carried out at single‐cell‐level alterations PLWH after ART. increased decreased compared IRs NCs. There gaps transition cellsinto

Language: Английский

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Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1295 - 1295

Published: Feb. 3, 2025

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive losses before 24 weeks gestation. It affects 3-5% women who are attempting to conceive. RPL can stem from a variety causes and frequently associated with psychological distress diminished quality life. By contrast, recurrent implantation failure (RIF) refers inability achieve successful after three high-quality embryo transfers at least instances egg donation. RIF shares several causative factors RPL. The immunological underpinnings these conditions involve alterations in uterine NK cells, reductions M2 macrophages myeloid-derived suppressor an increased Th1/Th2 ratio, decreased Treg/Th17 presence shared ≥3 HLA alleles between partners, autoimmune disorders. Various therapeutic approaches have been employed address concerns, achieving varying degrees success, although some therapies remain contentious within medical community. This review intends explore implicated analyze treatments for conditions, which may include steroids, intravenous immunoglobulins, calcineurin inhibitors, anti-TNF antibodies, intralipid infusions, granulocyte colony-stimulating factor, lymphocyte immunotherapy.

Language: Английский

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Impact of systemic lupus erythematosus on the reproductive health of women before and after disease onset: an observational study

Rheumatology International, Journal Year: 2025, Volume and Issue: 45(3)

Published: Feb. 13, 2025

Language: Английский

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Association of Anti-Ro/SSA and Anti-La/SSB Autoantibodies With Pregnancy Outcome in the General Population

Materia Socio Medica, Journal Year: 2024, Volume and Issue: 36(1), P. 47 - 47

Published: Jan. 1, 2024

Autoimmune diseases encompass a diverse array of disorders that disturb the optimal functioning immune system, which is to eliminate ‘foreign or/and dangerous’ mistakenly target body’s own tissues. The exact causes and etiologies these are multifactorial mostly still unclear. Ro/SSA autoantibodies La/SSB, could be found in Sjögren’s disease (SJ), systemic lupus (SLE) other autoimmune disorders. Smoking, stress, UV exposure, vitamin D deficiency, genetic environmental factors have been identified as risk for rheumatic diseases. Over years, an ever-increasing incidence has observed general population, with female sex being at increased their occurrence. This fact raises question what should management pathological entities during pregnancy. Taking into account very significant impact on quality paitients’daily life seemingly augmented prevalence well preference reasonable arises context Given limited data global medical community regarding etiological mechanisms trigger onset diseases, pregnant women complex conundrum health professionals challenged face solve.

Language: Английский

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