Ferroptosis in Obstetrical and Gynecological Diseases: A Mini Review

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(8)

Published: Aug. 16, 2024

Ferroptosis is an iron-dependent form of non-apoptotic cell programmed death, characterized by the disturbance iron metabolism, accumulation lipid peroxides and disruption cellular antioxidant system. induces oxidative death through decrease capacity reactive oxygen species (ROS) in cells. In recent years, studies have confirmed that ferroptosis closely related to numerous organ injuries, degenerative pathologies even tumorigenesis therapeutic resistance tumors. While effect obstetrical gynecological diseases remains unclear relevant researches are still limited. this review, we summarize current understanding molecular mechanisms regulatory networks ferroptosis, together with potential physiological functions pathological roles clinical diseases. Importantly, our review also aims provide references for further its pathogenesis explore strategies targeting

Language: Английский

Exosomal miR-130a-3p confers cisplatin resistance in esophageal cancer by regulating ferroptosis via the suppression of METTL14-mediated m6A RNA methylation of FSP1

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113804 - 113804

Published: Dec. 16, 2024

Language: Английский