Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 23, 2024

The present umbrella review aims to collate and summarize the findings from previous meta-analyses on Triglyceride Glucose (TyG) Index, providing insights clinicians, researchers, policymakers regarding usefulness of this biomarker in various clinical settings. A comprehensive search was conducted PubMed, Scopus, Web Science up April 14, 2024, without language restrictions. AMSTAR2 checklist assessed methodological quality included meta-analyses. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software. total 32 studies finally included. results revealed significant associations between TyG index health outcomes. For kidney outcomes, a high significantly associated with an increased risk contrast-induced nephropathy (CIN) (OR = 2.24, 95% CI: 1.82–2.77) chronic disease (CKD) (RR 1.46, 1.32–1.63). High type 2 diabetes mellitus (T2DM) 3.53, 2.74–4.54), gestational (GDM) 2.41, 1.48–3.91), diabetic retinopathy (DR) 2.34, 1.31–4.19). Regarding metabolic diseases, higher patients obstructive sleep apnea (OSA) (SMD 0.86, 0.57–1.15), syndrome (MD 0.83, 0.74–0.93), non-alcoholic fatty liver (NAFLD) 2.36, 1.88–2.97) compared those these conditions. In cerebrovascular dementia 1.14, 1.12–1.16), cognitive impairment 2.31, 1.38–3.86), ischemic stroke 1.37, 1.22–1.54). cardiovascular showed heart failure (HF) (HR 1.21, 1.12–1.30), atrial fibrillation (AF) 1.22, 0.57–1.87), hypertension (HTN) 1.52, 1.25–1.85). is promising for screening predicting medical conditions, particularly related insulin resistance disorders. However, heterogeneity suggest need further high-quality research confirm refine utility index.

Language: Английский

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Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 23, 2024

Abstract Background Numerous meta-analyses have explored the association between triglyceride-glucose (TyG) index and diverse health outcomes, yet comprehensive assessment of scope, validity, quality this evidence remains incomplete. Our aim was to systematically review synthesise existing TyG outcomes assess evidence. Methods A thorough search PubMed, EMBASE, Web Science databases conducted from their inception through 8 April 2024. We assessed reviews using Measurement Tool Assess Systematic Reviews (AMSTAR) certainty Grading Recommendations, Assessment, Development Evaluation (GRADE) system. This study registered with PROSPERO (CRD: 42024518587). Results Overall, a total 95 associations 29 were included, investigating 30 outcomes. Of these, 83 (87.4%) statistically significant ( P < 0.05) according random effects model. Based on AMSTAR tool, 16 (55.2%) high none low quality. The evidence, by GRADE framework, showed that 6 (6.3%) supported moderate-quality When compared lowest category index, risk contrast-induced nephropathy (CIN) [relative (RR) = 2.25, 95%CI 1.82, 2.77], stroke in patients diabetes mellitus (RR 1.26, 1.18, 1.33) or acute coronary syndrome disease 1.56, 1.06, 2.28), prognosis artery (CAD)-non-fatal MI 2.02, 1.32, 3.10), severity CAD including stenosis 3.49, 1.71, 7.12) multi-vessel 2.33, 1.59, 3.42) increased index. Conclusion found positively associated many diseases CIN stroke, CAD, which might be useful identify people at high-risk for developing these diseases.

Language: Английский

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The Impact of Insulin Resistance on the Development of Post-PCI Contrast-Induced Nephropathy in Non-Diabetic STEMI.

PubMed, Journal Year: 2025, Volume and Issue: 41(1), P. 130 - 137

Published: Jan. 1, 2025

Contrast-induced nephropathy (CIN) is a condition characterized by rapidly decreasing renal funciton following the application of contrast material. Precutaneous coronary intervention (PCI) life-saving treatment method that should be applied under emergent conditions. Unfortunately, incidence CIN after PCI common. Patients with insulin resistance or diabetes have greater risk developing than most population. Therefore, studies on predictive effects indicators are gaining momentum. One popular triglyceride/glucose-body mass index (TyG-BMI). In this study we aimed to evaluate effect TyG-BMI CIN. A total 960 patinets who underwent emergency due ST elevation myocardial infarction (STEMI) between 2020 and 2023 were included in study. Laboratory demographic parameters compared patients did not develop While developed 120 980 study, it 860 patients. There significant differences groups terms age (p < 0.001), gender = 0.005), presence hypertension 0.021), heart rate 0.049), amount material left ventricular ejection fraction stent length 0.022), SYNTAX score fasting plasma glucose baseline creatinine glomerular filtration uric acid C reactive protein (CRP) creatin kinase myocard band (CKMB) 0.019), CKMB peak 0.030), triglyceride 0.017), 0.001). CRP, creatinine, asid, material, independent predictors for development was predictor STEMI patient addition, predicitive power stronger triglyceride-glucose index.

Language: Английский

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Predictive Value of Urinary KIM-1, TIMP-2 and sTREM-1 for Contrast-Induced Acute Kidney Injury in Elderly Patients After Percutaneous Coronary Intervention

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 145 - 152

Published: Jan. 1, 2025

We aimed to address the predictive value of urinary kidney injury molecule-1 (KIM-1), tissue inhibitor metalloproteinases-2 (TIMP-2) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for contrast-induced acute (CI-AKI) in elderly patients after percutaneous coronary intervention (PCI). One hundred thirty-six who underwent PCI were separated into CI-AKI group (n = 36) non-CI-AKI 100) based occurrence operation, their general data collected. Blood urine specimens collected before operation (at time admission) 6 h, 12 24 h 48 preserved future use. Serum creatinine (Scr) levels tested an estimated glomerular filtration rate (eGFR) was counted. Urinary KIM-1, TIMP-2 sTREM-1 assessed preoperative as well postoperative compared. The early diagnostic at hours postoperatively analyzed by receiver operating characteristic (ROC) curve. After Scr higher versus group. At postoperatively, eGFR lower group; KIM-1 contrast that ROC curve analysis showed areas under (AUCs) TIMP-2, diagnosing 0.852 (95% CI: 0.768-0.936), 0.810 0.723-0.898), 0.874 0.804-0.943), cut-off values 45.93 ng/L, 1.63 ng/mL, 61.48 respectively, with sensitivities 66.70%, 58.30%, 72.20%, specificities 95.00%, 93.00%, 91.00%, respectively (all P < 0.05). can respond changes renal function have good application diagnosis CI-AKI.

Language: Английский

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Combined Use of Pan-Immune-Inflammation Value and Triglyceride-Glucose Index for Risk Prediction of Contrast-Induced Nephropathy After Coronary Angiography in Patients with STEMI

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: 126(2), P. 211 - 218

Published: Feb. 1, 2025

Abstract Aim The pan-immune-inflammation value (PIV) and triglyceride-glucose (TyG) index are very important parameters that predict contrast-induced nephropathy (CIN) well in patients with ST-elevation myocardial infarction (STEMI) underwent percutaneous coronary intervention (PCI). There limited data on the predictive of CIN derived from combination PIV TyG compared to use alone STEMI who PCI. We aimed evaluate ability index, routinely obtained admission, identify at risk CIN. Method Between 2018 2024, 2367 PCI were included. was defined as a 25% or 0.5 mg/dL increase creatinine baseline within 48–72 h after Receiver operating curve (ROC) analysis performed development Results In ROC analysis, cut-off values for best predicting 548, 8.97 respectively. two markers most powerful predictor when included single variable such high index. Furthermore, co-presence exhibited highest specificity CIN(82%) PIV(77%) index(71%) alone. Conclusion simple cost-effective assessment, may be more reliable prognostic indicator undergoing than

Language: Английский

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Triglyceride-glucose index as a marker in cardiovascular diseases; a bibliometric study and visual analysis

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(3), P. 1487 - 1505

Published: Feb. 26, 2025

Objective: This study aims to conduct a bibliometric analysis of the triglyceride-glucose (TyG) index in relation cardiovascular disorders. Methods: Data for were extracted from Web Science Core Collection database on 13 July 2024. We utilized VOSviewer, CiteSpace, and Biblioshiny tools analysis. Results: The revealed marked increase research outputs TyG recent years, peaking with 137 publications 2023. China emerged as leading contributor, followed by USA. Chinese Academy Medical Sciences Peking Union College among top contributing institutions. Shouling Wu Shuohua Chen authors, journal Cardiovascular Diabetology publishing most articles this topic. Keyword identified “insulin-resistance” frequently occurring term, “risk.” Cluster eleven key areas, including “percutaneous coronary intervention,” “obesity indicators,” “arterial stiffness,” “heart failure.” Conclusion: highlights expanding role metabolic research. Key clusters such percutaneous intervention, obesity indicators, arterial stiffness, heart failure, new-onset hypertension, predicting outcomes, subclinical artery disease emphasize its wide applicability across diverse clinical settings. keyword “risk” was underscoring importance risk assessment, alongside growing use prognostic applications. These findings reflect increasing recognition pivotal biomarker medicine encourage further exploration integration.

Language: Английский

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Triglyceride-glucose index as a predictor of contrast-induced nephropathy in nondiabetic patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention: a retrospective study

Coronary Artery Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Background Contrast-induced nephropathy (CIN) is a significant complication following percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. This study aimed to evaluate the association between triglyceride-glucose (TyG) index and CIN development nondiabetic patients with STEMI undergoing PCI. Methods retrospective included 1625 treated PCI within 12 h of symptom onset. was defined as an increase serum creatinine greater than 25% or equal 0.5 mg/dl from baseline 48–72 postprocedure. Patients were stratified into quartiles based on TyG levels. Logistic regression receiver operating characteristic (ROC) curve analyses performed identify independent predictors determine optimal cutoff. Results Among patients, 14% developed CIN. highest quartile (Q4) exhibited incidence (27%, P < 0.01). The independently associated [odds ratio (OR): 2.054, 95% confidence interval (CI): 1.564–2.697, 0.001) alongside (OR: 1.666, CI: 1.053–2.635, = contrast volume 1.003, 1.002–1.005, 0.005). ROC analysis yielded cutoff value 9.11 (AUC: 0.722)) 70% sensitivity 62% specificity. Conclusion reliable marker for predicting Its CIN, combined its cost-effectiveness, highlights potential improving risk stratification this high-risk group.

Language: Английский

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Association between high triglyceride-glucose index and MACCE in hypertriglyceridemia patients undergoing percutaneous coronary intervention

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Background With a focus on metabolism-related cardiovascular diseases, the triglyceride-glucose (TyG) index has been used as surrogate marker of insulin resistance in prognosis coronary heart disease. However, prognostic role TyG patients with elevated triglycerides, still requires further research. This study aimed to investigate association between and Major Adverse Cardiac Cerebrovascular Events (MACCE) hypertriglyceridemia undergoing drug-eluting stent percutaneous intervention (DES-PCI). Methods Out 2250 patients, 813 who underwent DES-PCI were retrospectively analyzed. MACCE was regarded primary endpoint. Kaplan–Meier (KM) curves evaluate different endpoints. Restricted cubic spline (RCS) analysis examine relation MACCE. Subgroup conducted interaction subgroup indicators. Results Cox regression identified an independent predictor (hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.15–2.04, P = 0.004). Receiver operating characteristic (ROC) determined 9.19 cutoff value index. The curve indicated that &gt; had higher risks (HR 2.23, CI 1.35–3.67, 0.002), MACE 2.38, 1.39–4.09, unplanned repeat revascularization 2.05, 1.02–4.09, 0.043) all-cause death 3.31, 95%CI 1.15–9.47, 0.026) than those low RCS revealed linear risk (P for nonlinearity 0.879, overall trend 0.044). Conclusions demonstrated high is associated increased MACCE, suggesting may serve valuable DES-PCI.

Language: Английский

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Triglyceride‐glucose index trajectories predict adverse cardiovascular outcomes in elderly heart failure patients with Diabetes: A retrospective cohort study

Aging Medicine, Journal Year: 2024, Volume and Issue: 7(6), P. 717 - 726

Published: Dec. 1, 2024

Abstract Objective Evaluating the change trajectories of triglyceride‐glucose (TyG) index calculated after multiple tests in elderly heart failure (HF) patients may have clinical implications for predicting long‐term adverse cardiovascular events (MACEs). Methods This retrospective study included 1184 HF (LVEF ≥50%) with diabetes admitted to our center between January 2015 and 2020. Based on TyG levels detected during exposure period annual measurements, three distinct were determined using latent mixture modeling: low‐stable group (TyG <8.26, n = 367), medium‐stable 8.26–9.06, 613), high‐increasing >9.06, 204). The primary endpoint was composite outcome MACEs. Results There significant increases prevalence several risk factors conditions, such as male gender, BMI, current smoker, hyperlipidemia, atrial fibrillation, old myocardial infarction, fasting glucose, triglycerides, uric acid levels, from Low‐Stable Group High‐Increasing (all P < 0.05). During a median follow‐up 29 months (range, 18–46 months), 181 MACEs occurred. Kaplan–Meier analyses curve showed significantly increased groups compared ( HR 2.528, 95% CI : 1.665–3.838; 2.706, 1.722–4.255, respectively). Furthermore, rates failure‐related hospitalizations, nonfatal infarctions non‐fatal stroke groups. Multivariable Cox regression revealed that age 1.728), smoker 1.385), infarction 1.593), chronic renal disease 1.682), HbA1c 1.816), NT‐proBNP 2.471), trajectory 2.112) SGLT2 inhibitors 0.841) independently associated occurrence Conclusions is strongly T2DM, suggesting further optimize stratification model events.

Language: Английский

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Predictive Value of Triglyceride Glucose Index on the Risk of Acute Kidney Injury in Patients with Acute Myocardial Infarction

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1216 - 1227

Published: Jan. 1, 2024

Language: Английский

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