Association between systemic inflammation response index and chronic kidney disease: a population-based study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Introduction Our objective was to explore the potential link between systemic inflammation response index (SIRI) and chronic kidney disease (CKD). Methods The data used in this study came from National Health Nutrition Examination Survey (NHANES), which gathers 1999 2020. CKD diagnosed based on low estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m 2 or albuminuria (urinary albumin-to-creatinine ratio (ACR) more 30 mg/g). Using generalized additive models weighted multivariable logistic regression, independent relationships SIRI other inflammatory biomarkers (systemic immune-inflammation (SII), monocyte/high-density lipoprotein (MHR), neutrophil/high-density (NHR), platelet/high-density (PHR), lymphocyte/high-density (LHR)) with CKD, albuminuria, low-eGFR were examined. Results Among recruited 41,089 participants, males accounted for 49.77% total. Low-eGFR, prevalent 8.30%, 12.16%, 17.68% people, respectively. shown be positively correlated (OR = 1.24; 95% CI: 1.19, 1.30). Furthermore, a nonlinear correlation discovered CKD. are both two sides breakpoint (SIRI 2.04). Moreover, increased levels associated greater prevalences (albuminuria: OR 1.27; 1.21, 1.32; low-eGFR: 1.11; 1.05, 1.18). ROC analysis demonstrated that, compared indices (SII, NHR, LHR, MHR, PHR), exhibited superior discriminative ability accuracy predicting low-eGFR. Discussion When low-eGFR, may show up as biomarker when PHR). American adults elevated SIRI, SII, PHR should attentive risks their health.

Language: Английский

---

Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

The prevalence of type 2 diabetes mellitus (T2DM) remains high and biomarkers related to T2DM are needed be investigated. This study aimed investigate the association between neutrophil percentage-to-albumin ratio (NPAR) with all-cause mortality risk cardiovascular disease (CVD) in community-dwelling individuals T2DM. prospective cohort included 3602 adults aged 20 or above who were diagnosed by American Diabetes Association criteria US National Health Nutrition Examination Survey (NHANES) database from 1999 2016, followed up until 2019. Multivariable Cox proportional hazards regression models utilized determine relationship NPAR mortality. Restricted cubic spline analyses employed explore nonlinear assessment nonlinearity was conducted using likelihood test. After adjustment, for highest group (≥ 15.40) compared lowest serum reference (< 13.30) 1.62 (95% CI, 1.36, 1.94) P values < 0.001. Nevertheless, versus 1.41 0.99, 2.00) a value 0.06. Among patients T2DM, levels exhibited correlation both CVD risk, 0.001 both. identified significant elevated an increased among (T2DM). Conversely, no found

Language: Английский

---

Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1256 - 1256

Published: Feb. 22, 2024

(1) Background: The systemic inflammatory response index (SIRI; neutrophil count × monocyte/lymphocyte count), and the immune-inflammation (SII; platelet count/lymphocyte count) are recently proposed biomarkers to assess immune status. However, data on SIRI SII still relatively lacking do not definitively exhaustively define their role as predictors of an adverse prognosis in acute myocardial infarction (AMI). aim present study was evaluate determinants well prognostic power ST-elevation (STEMI). (2) Methods: A total 105 STEMI patients (74 males, 70 ± 11 years) were studied (median follow-up 54 25 months, 24 deaths). (3) Results: main creatinine brain natriuretic peptide (BNP) (multivariate regression). Patients with higher (>75th percentile, 4.9) 1257.5) had lower survival rates than those low SIRI/SII group (Kaplan–Meier analysis). Univariate Cox regression revealed that high associated mortality (HR: 2.6, 95% CI: 1.1–5.8, p < 0.05; 2.2, 1–4.9, ≤ 0.05, respectively); however, these associations lost significance after multivariate adjustment. (4) Conclusions: association significantly affected by confounding factors our population, especially BNP, which both indices outcome.

Language: Английский

---

Elevated neutrophil percentage-to-albumin ratio predicts increased all-cause and cardiovascular mortality among individuals with diabetes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 13, 2024

Evidence regarding the neutrophil percentage-to-albumin ratio (NPAR) and mortality risk in diabetes patients is scarce. This study aimed at investigating prognostic value of NPAR for with diabetes. retrospective analysis was conducted on 6,962 diabetic from NHANES database. Restricted cubic spline (RCS) used to visualize association risk. Weighted multivariable Cox regression models subgroup analyses were adopted assess all-cause cardiovascular mortality. Time-dependent receiver operating characteristic curve (ROC) evaluate accuracy predicting survival outcomes. Mediation explored indirect impact mediated through eGFR. During a median follow-up 6.7 years, there 1,804 deaths recorded, including 602 deaths. The RCS showed that has J-shaped mortality, positive linear CVD Each one-unit increase linked 14% 12% increased respectively. consistent based age, sex, race, BMI, hypertension, CKD, history CVD. time-dependent ROC area under 0.809 0.780 In mediation analyses, eGFR partially these relationships. An elevated independently associated patients.

Language: Английский

---

Association between inflammatory biomarkers and gestational diabetes mellitus in women aged 20–44: a cross-sectional analysis of NHANES 2007–2018

Gynecological Endocrinology, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 3, 2025

Inflammation exerts an essential role in gestational diabetes mellitus (GDM), but the relationship between peripheral blood inflammatory markers and GDM remains unclear. The purpose of this study was to explore US adults. Data were extracted from National Health Nutrition Examination Survey. Five derived complete count. Survey-weighted multivariable logistic regression models used assess association GDM. Restricted cubic splines subgroup analyses conducted validate stability results. Finally, a total 2363 women aged 20-44 included based on specific criteria, with 229 self-reported cases (9.69%). increased lymphocyte-monocyte ratio (LMR) associated higher risk GDM, aOR = 1.82 (CI:1.30-2.56). Compared lowest tertile, highest tertile group LMR showed significantly 2.24 (CI: 1.28-2.85). Conversely, systemic inflammation response index (SIRI) negatively 0.61 (95% CI: 0.40-0.94). And high platelet-lymphocyte (PLR) levels are related lower No non-linear relationships observed. Furthermore, analysis revealed that LMR, SIRI, remained consistent overall Our indicated PLR, SIRI may be potential predictors Further large-scale prospective is needed investigate PLR

Language: Английский

---

Assessment of immune function in individuals without and with obesity and normoglycemia, glucose intolerance, or type 2 diabetes: primary findings of the NutrIMM study, a single-arm controlled feeding trial

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and diabetic kidney disease in patients with diabetes in the United States: a cross-sectional study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 27, 2024

Language: Английский

---

The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 9, 2024

Abstract Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease often accompanied by low-grade inflammation. Recently, the neutrophil-to-lymphocyte ratio (NLR) has garnered researchers’ interest as an emerging inflammation biomarker. This study aimed to comprehensively explore relationship between NLR and T2DM using National Health Nutrition Examination Survey (NHANES) database. Method We employed cross-sectional design analyze data from five NHANES cycles 2007 2016, excluding individuals with incomplete data. utilized weighted logistic regression model, subgroup analyses, restricted cubic spline (RCS) analysis assess potential T2DM. Results A total of 9903 participants were eligible for analysis, which 1280 diagnosed The group exhibited significantly higher levels than non-T2DM group. After adjusting confounders, elevated associated increased risk developing T2DM, indicated odds (OR) 1.14, 95% CI: (1.05,1.24), P = 0.003. results analyses revealed significant interaction effect concerning race hypertension ( < 0.05). In contrast, no interactions found age, sex, education level, body mass index (BMI), smoking status, recreational activities, alcohol drinker > RCS showed non-linear inflection point at 2.27 (all non-linearity Conclusion Our indicates that

Language: Английский

---

Therapeutic potential of stromal vascular fraction in early diabetic nephrotoxicity: a histomorphometric and immunohistochemical analysis in type 2 diabetes rat model

Folia Morphologica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Diabetic nephropathy (DN), a common complication of type 2 diabetes (T2D), significantly contributes to end-stage kidney disease (ESKD). Despite conventional treatments aimed at slowing progression, there is pressing need for novel therapies. This study evaluates the potential therapeutic impact adipose tissue derived stromal vascular fraction (SVF) on early diabetic nephrotoxicity in rat model. Thirty-one male albino rats were divided into control and groups, with latter further split untreated (T2Da) SVF-treated (T2Db) subgroups. Biochemical, histological, immunohistochemical, morphometric analyses conducted. We demonstrated that SVF treatment reduced oxidative stress, lowered serum creatinine, improved renal architecture by mitigating fibrosis cellular infiltration, suggesting enhanced regeneration inflammation. also facilitated repair, indicated increased endothelial cell proliferation glomerular damage. underscores SVF's as promising regenerative approach managing early-stage DN, warranting research elucidate its mechanisms.

Language: Английский

---

Development of Predictive Models for Progression from Diabetic Kidney Disease to End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Retrospective Cohort Study

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 383 - 398

Published: Feb. 1, 2025

Aim: The aim of this study was to develop a predictive model for the progression diabetic kidney disease (DKD) end-stage renal (ESRD) and evaluate effectiveness pathology failure risk equation (KFRE) in context. Methods: comprised two parts. first part involved 555 patients with clinically diagnosed DKD, while second focused on 85 biopsy-proven DKD. Cox regression analysis competing were employed identify independent predictors. Time-dependent receiver operating characteristic (ROC) used prediction performance, area under curve (AUC) calculated assess model's accuracy. Results: developed DKD identified 5 predictors (body mass index (BMI), estimated glomerular filtration rate (eGFR), 24-hour urinary total protein (UTP), systemic immune-inflammatory (SII), controlling nutritional status (CONUT), whereas Competing risks included 4 (BMI, eGFR, UTP, CONUT). Among combined prognostic integrating KFRE, interstitial fibrosis tubular atrophy (IFTA), SII BMI demonstrated enhanced ability at years. models offer improved accuracy over existing methods by incorporating novel inflammatory indices, making them more applicable clinical settings. Conclusion: proved be effective assessing ESRD. Additionally, IFTA, SII, demonstrates high performance. Future studies should validate these larger cohorts explore their integration into routine practice enhance personalized assessment management. Keywords: disease, pathologies,

Language: Английский

---