Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1399 - 1399
Published: Oct. 31, 2024
Metabolic Score for Visceral Fat (METS-VF) is a novel indicator estimating intra-abdominal fat, yet its connection with coronary artery calcification (CAC) remains uncharted. Our research aims to explore the METS-VF indicator's link CAC while comparing performance against relevant anthropometric indices.
Language: Английский
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 10, 2024
The Visceral Adiposity Index (VAI) assesses visceral fat and related metabolic risks. However, its precise correlation with sarcopenia is unclear. This study aimed to examine this correlation. A cross-sectional analysis was conducted using NHANES data from 2011 2018. To correct VAI skewness, a logarithmic transformation applied. Multiple covariates were included, logistic regression employed explore the relationship between sarcopenia. Restricted cubic spline (RCS) threshold saturation analyses used investigate nonlinear relationship. Subgroup evaluated effects of various stratification factors. Sensitivity additive tested robustness findings. included 4688 individuals. Participants had significantly higher values. Logistic revealed significant positive connection Log (OR 2.09, 95% CI 1.80-2.43) after adjusting for variables. RCS showed correlation, identifying breakpoint at = 1.51. left breakpoint, each unit increase in correlated likelihood 2.54, 1.74-3.79); right, increases did not affect prevalence. suggested as an independent risk factor. confirmed main findings' robustness. Among American adults, associated sarcopenia, values potentially increasing prevalence Monitoring critical early identification high-risk individuals interventions delay or minimize onset progression
Language: Английский
Citations
5
Clinical Endocrinology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
ABSTRACT Objective Patients with mild autonomous cortisol secretion (MACS) are at increased risk of cardiometabolic outcomes, such as hyperglycemia, metabolic syndrome, and cardiovascular diseases. Nonalcoholic fatty liver disease (NAFLD) is also associated risk. We aimed to investigate the prevalence predictors NAFLD in metabolically healthy subjects MACS. Methods Forty patients MACS 60 nonfunctioning adrenal incidentaloma (NFAI) matched for age, gender, body mass index were included. excluded various diseases that may lead NAFLD, diabetes, diseases, disorders. Non‐alcoholic was evaluated unenhanced abdominal computed tomography noninvasive indices. Results had lower mean attenuation values (Hounsfield units, HU) than those NFAI ( p = 0.001). Visceral adiposity index, hepatic steatosis higher group 0.009, 0.002, 0.023, respectively). However, there no significant association between HU value these There a serum level after 1 mg dexamethasone suppression test (DST) independent other traditional factors models performed multivariable linear regression analysis. Conclusions Our findings suggest an DST predictor
Language: Английский
Citations
0
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 20(8), P. 622 - 632
Published: Jan. 4, 2025
Background. The progression of heart failure (HF) in individuals with carbohydrate metabolism disorders is one the many fatal complications among comorbid conditions. It found that risk developing HF women diabetes mellitus (DM) five times higher than those without it. Due to both heterogeneity and syntropy etiopathogenetic mechanisms occurrence, prevalence DM increasing world population, delayed treatment potentiates a poor prognosis. main task medical community undoubtedly early diagnosis preserved ejection fraction (HFpEF) prescription justified pathogenetic treatment, especially for prediabetes/type 2 (T2DM). Therefore, strategy pathology use patient-oriented approaches taking into account gender characteristics search alternative ways achieve glycemic goals safely HFpEF disorders. purpose study was examine results 12-week course metformin alone or combination dapagliflozin an emphasis on correction functional iron deficiency prediabetes/T2DM. Materials methods. Sixty female who met criteria were examined divided two groups: group I (n = 30) — prediabetes; II T2DM. Depending therapy, patients groups randomized subgroup A (IA: n 15; IIA: 15), received (at daily dose 500–2000 mg) B (IB: IIB: 15) (500–2000 mg/day) (10 mg/day). According design scientific study, all at beginning after 12 weeks therapy underwent assessment basic anthropometric data, set laboratory examinations, clinical instrumental diagnosis. Results. In IB group, high effectiveness confirmed according indicators (glycated hemoglobin (HbA1C): ∆–10.67 %, p < 0.001) significant increase left ventricular (∆+7.73 compared receiving (∆–1.53 > 0.5). When using studied treatments prediabetes, it reliable normalization control chance (odds ratio 0.12, 95% confidence interval 0.011–1.339) preventing additional together confirms safe transferrin saturation (IB/IIB ∆+38.51 0.001/∆+ 29.59 0.001); content serum ∆+14.93 10.07 0.5) tendency towards compensatory hypoferritinemia. On background (daily 2000 mg, 10 mg), there comparable decrease IIB (IIA/IIB HbA1C treatment: ∆–1.75 %/∆–10.67 0.001, respectively) improvement parameters NT-pro-BNP content: ∆–5.96 0.05/∆–13.65 0.001; fraction: ∆+1.38 %/∆+9.00 respectively). Conclusions. proposed personalized approaches prediabetes have prognosis-modifying effect manifestations effective control. Timely contributes deficiency. As result combined compensation signs These conclusions contribute better understanding therapeutic potential prevention polypharmacy comorbidity.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 21, 2025
Background Previous studies have shown that pro-inflammatory diets increase the risk of coronary heart disease (CHD) and all-cause mortality. The dietary inflammatory index (DII) is a quantitative measure inflammation, its accuracy has been validated by several studies. Methods This study included 43,842 participants aged ≥18 years from National Health Nutrition Examination Survey (NHANES) 1999–2018. data CHD was obtained through questionnaire survey, DII calculated using 24-h recall data. Generalized linear models logistic regression were used to determine mediation factors, subgroup analyses conducted evaluate interaction between CHD. Mean decrease in Gini (MDG) importance individual components. Results age 49.81 ± 18.10 years, with 20,793 (47.4%) being male. A total 1,892 (4.3%) diagnosed CHD, median score 1.33 (0.11, 2.40). After adjusting for potential confounders, analysis revealed independently associated [OR: 1.049 (1.012–1.087), p = 0.008]. Triglyceride-glucose index, visceral adiposity body mass waist-to-height ratio, high-density lipoprotein, glomerular filtration rate (all < 0.05) may mediate relationship Subgroup showed more sensitive <75 ( 0.001), females 0.028), those low cholesterol levels 0.004), individuals Framingham scores 0.005). MDG indicated carbohydrate, vitamin C iron intake greatest impact on Conclusion suggests various metabolic lipid indicators play mediating role greater adverse traditional low-risk populations.
Language: Английский
Citations
0
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Language: Английский
Citations
0
Art of Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 46 - 52
Published: April 2, 2025
As a result of insulin resistance (IR), women reproductive age have higher risk the development and progressing type 2 diabetes (T2DM), which contributes to decrease in fertility potential. Despite ongoing scientific discoveries fields endocrinology patient-centered treatment goals, significant part global population lacks compensation for T2DM. Therefore, one alternative approaches treating with T2DM should be considered achieving glycemic targets while simultaneously correcting IR. The aim is evaluate efficacy sodium-glucose cotransporter inhibitors (SGLT2i) correction carbohydrate lipid metabolism A 12-week study involved 30 who met criteria. Based on their hypoglycemic therapy, participants were divided into two groups: group (n=15), received standard medication therapy (SMT) combined SGLT2i (dapagliflozin 10 mg/daily doses or empagliflozin 10-25 doses), control SMT consisting metformin 2000 doses, alpha-lipoic acid 600 inositol doses. groups comparable regarding primary disease its duration, age, body composition, anthropometric parameters, laboratory-instrumental characteristics IR, characteristics. Analysis after 12 weeks revealed differences outcomes between groups. Women group, іSGLT2 as regimen, experienced statistically reduction IR markers. Specifically, HOMA-IR index decreased 2.3-fold compared baseline values (study vs. group: ∆+127.77%; p<0.001). Improvements also observed composition: 1.4-fold visceral fat content (VFC) 1.3-fold total percentage ∆+38.25%; p=0.002 ∆+33.23%; p=0.003, respectively). Patients achieved better average level glycated hemoglobin (HbA1C) 7.26±0.86% (p<0.001) 8.48±0.80% representing an improvement ∆+16.80% (p=0.003). Additionally, metabolic age—a crucial indicator overall health—improved significantly group. It by 4.25%, resulting mean 48.20±4.33 years (p<0.001), 55.07±4.59 findings this highlight potential combining This therapeutic approach not only achieves but facilitates comprehensive symptoms, normalizes metabolism, improves parameters. With favorable safety profile demonstrated efficacy, integration management protocols offers promising optimizing specific patient population. These results underscore importance personalized strategies aimed at addressing both health
Language: Английский
Citations
0
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 15, 2025
Visceral adiposity index (VAI) vividly reflects body fat distribution through comprehensively integrating mass index, sex, waist circumference, triglycerides, and high-density lipoprotein cholesterol. While VAI is an established predictor of various clinical outcomes, its relationship with premature mortality life expectancy remains unclear. To explore the association between or in a nationally representative cohort US adults. This study included adults who participated National Health Nutrition Examination Survey (NHANES) from 1999 to 2018, linked Death Index December 31, 2019. Data were analyzed August October, 2024. was categorized into quartiles lowest Q1 highest Q4. Primary endpoints (death before 80 years age) expectancy. A total 43,672 participants (women: 22,164; men: 21,508) aged > 20 included. Over median follow-up 9.2 (IQR: 4.9-13.8), 3,187 deaths documented. Higher significantly associated increased multi-adjusted risk compared (Q3 vs. Q1: hazard ratio [HR], 95% confidence interval [CI]: 1.30, 1.05 1.61; Q4 1.68, 1.34 2.11). particularly pronounced women 1.53, 1.01 2.30; 2.36, 1.52 3.68), significant linear trends (P < 0.001). Estimated at age 40 41.45 (95% CI: 41.24 41.66), 41.32 (41.11 41.53), 40.55 (40.35 40.75), 39.26 (39.08 39.45) Q1, Q2, Q3, VAI, respectively. By estimated reduced by 3.33 1.24 men, Q1. race ethnicity, it shortened 3.90 Black 1.68 White group, In this nationwide study, higher among These associations we heterogeneous more participants.
Language: Английский
Citations
0
Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1399 - 1399
Published: Oct. 31, 2024
Metabolic Score for Visceral Fat (METS-VF) is a novel indicator estimating intra-abdominal fat, yet its connection with coronary artery calcification (CAC) remains uncharted. Our research aims to explore the METS-VF indicator's link CAC while comparing performance against relevant anthropometric indices.
Language: Английский
Citations
2