High estrogen induces trans-differentiation of vascular smooth muscle cells to a macrophage-like phenotype resulting in aortic inflammation via inhibiting VHL/HIF1a/KLF4 axis DOI Creative Commons
Ruijing Zhang, Heng Wang, Xing Cheng

et al.

Aging, Journal Year: 2024, Volume and Issue: 16(11), P. 9876 - 9898

Published: June 5, 2024

Estrogen is thought to have a role in slowing down aging and protecting cardiovascular cognitive function. However, high doses of estrogen are still positively associated with autoimmune diseases tumors systemic inflammation. First, we administered exogenous female mice for three consecutive months found that the aorta on develops inflammatory manifestations similar Takayasu arteritis (TAK). Then, vitro intervention was performed mouse aortic vascular smooth muscle cells (MOVAS cells). Stimulated by concentrations estradiol, MOVAS showed decreased expression contractile phenotypic markers increased macrophage-like markers. This shift blocked tamoxifen Krüppel-like factor 4 (KLF4) inhibitors enhanced Von Hippel-Lindau (VHL)/hypoxia-inducible factor-1α (HIF-1α) interaction inhibitors. It suggests estrogen-targeted regulation VHL/HIF-1α/KLF4 axis induces transformation (VSMC). In addition, estrogen-regulated conversion VSMC macrophages key mechanism estrogen-induced inflammation, which justifies risk clinical use replacement therapy.

Language: Английский

The effects of estradiol on subcortical brain volumes in perimenopausal-onset depression DOI
Kathryn Gibson,

Melissa Walsh,

Megan Hynd

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Free Testosterone and Percentage Free Testosterone are Superior Marker than Total Testosterone in Evaluation of Male Infertility—A Case-control Study DOI

Waseem Andrabi,

Sushil Kumar Singh,

Girish Chandra Makker

et al.

Fertility Science and Research, Journal Year: 2025, Volume and Issue: 12, P. 3 - 3

Published: Feb. 28, 2025

Objectives To evaluate the hormonal profiles, specifically focusing on gonadotropins (FSH, LH) and testosterone levels (Total, free Percentage Testosterone), in infertile males (oligozoospermia azoospermia) compared to fertile controls, which of these hormones provide a better clinical relevance during evaluation male reproductive health. Material Methods Study design-A retrospective study total 250 patients were studied categorized into: 172 with oligozoospermia (68.8%), 78 azoospermia (31.2%) 52 included as control group (proven males). Blood samples collected from all participants measure serum Follicle-stimulating hormone (FSH), Luteinizing (LH), Estradiol, Prolactin Total testosterone, Free along controls comparison between (both oligozoospermic azoospermic) was performed using appropriate statistical methods check significance. Results Significant differences observed FSH, LH, percentage azoospermic when group. However, no significant found estradiol, prolactin, males. Conclusion The highlights critical role fertility. alteration men suggests that is crucial for understanding diagnosing infertility. Anomalies may contribute pathophysiology spermatogenic dysfunctions, emphasizing importance endocrine function

Language: Английский

Citations

0
Phthalates and Non-Phthalate Plasticizers and Thyroid Dysfunction: Current Evidence and Novel Strategies to Reduce Their Spread in Food Industry and Environment DOI Creative Commons
Francesca Gorini, Alessandro Tonacci, Chiara Sanmartin

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 222 - 222

Published: March 19, 2025

Thyroid hormones (THs) play a crucial role in various biological functions, including metabolism, cell growth, and nervous system development, any alteration involving the structure of thyroid gland TH secretion may result disease. Growing evidence suggests that phthalate plasticizers, which are commonly used wide range products (e.g., food packaging materials, children’s toys, cosmetics, medical devices), can impact function, primarily affecting serum levels THs TH-related gene expression. Like compounds, recently introduced alternative plasticizers leach from their source material into environment, particularly foods, although so far only very limited number studies have investigated toxicity. This review aimed at summarizing current knowledge on non-phthalate dysfunction disease, describing major mechanisms underlying this relationship. We will also focus industry as one main players for massive spread such compounds human body, turn conveyed by edible compounds. Given increasing worldwide use essential humans, novel strategies should be envisaged to reduce burden and, general, health.

Language: Английский

Citations

0
High estrogen induces trans-differentiation of vascular smooth muscle cells to a macrophage-like phenotype resulting in aortic inflammation via inhibiting VHL/HIF1a/KLF4 axis DOI Creative Commons
Ruijing Zhang, Heng Wang, Xing Cheng

et al.

Aging, Journal Year: 2024, Volume and Issue: 16(11), P. 9876 - 9898

Published: June 5, 2024

Estrogen is thought to have a role in slowing down aging and protecting cardiovascular cognitive function. However, high doses of estrogen are still positively associated with autoimmune diseases tumors systemic inflammation. First, we administered exogenous female mice for three consecutive months found that the aorta on develops inflammatory manifestations similar Takayasu arteritis (TAK). Then, vitro intervention was performed mouse aortic vascular smooth muscle cells (MOVAS cells). Stimulated by concentrations estradiol, MOVAS showed decreased expression contractile phenotypic markers increased macrophage-like markers. This shift blocked tamoxifen Krüppel-like factor 4 (KLF4) inhibitors enhanced Von Hippel-Lindau (VHL)/hypoxia-inducible factor-1α (HIF-1α) interaction inhibitors. It suggests estrogen-targeted regulation VHL/HIF-1α/KLF4 axis induces transformation (VSMC). In addition, estrogen-regulated conversion VSMC macrophages key mechanism estrogen-induced inflammation, which justifies risk clinical use replacement therapy.

Language: Английский

Citations

0