Adipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 13, 2024

Abstract Coronary artery disease has a high mortality rate and is striking public health concern, affecting substantial portion of the global population. On early onset myocardial ischemia, thrombolytic therapy coronary revascularization could promptly restore bloodstream nutrient supply to ischemic tissue, efficiently preserving less severely injured myocardium. However, abrupt re-establishment blood flow triggers significant discharge previously accumulated oxidative substances inflammatory cytokines, leading further harm referred as ischemia/reperfusion (I/R) injury. Diabetes significantly raises vulnerability heart I/R injury due disrupted glucose lipid processing, impaired insulin sensitivity metabolic signaling, increased responses. Numerous studies have indicated that adipokines are crucial in etiology pathogenesis obesity, diabetes, hyperlipidemia, hypertension, disease. Adipokines such adiponectin, adipsin, visfatin, chemerin, omentin, apelin, which possess protective properties against activity resistance, been shown confer protection conditions atherosclerosis, hypertrophy, injury, diabetic complications. other hand, leptin resistin, known for their pro-inflammatory characteristics, linked elevated cardiac deposition, fibrosis. Meteorin-like (metrnl) exhibits opposite effects various pathological conditions. data on I/R, especially still incomplete controversial. This review focuses recent research regarding categorization function muscle, identification different signaling pathways involved under conditions, aiming facilitate exploration therapeutic strategies diabetes.

Language: Английский

Efficacy and safety of salvianolate injection in treating acute myocardial infarction: a meta-analysis and systematic literature review

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Salvianolate for injection (SFI) is a widely used treatment acute myocardial infarction (AMI). This study aims to assess the efficacy and safety of SFI in treating AMI by synthesizing evidence from published randomized controlled trials (RCTs).

Language: Английский