Association between a body shape index and female infertility: a cross-sectional study

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 4, 2024

Language: Английский

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Combination of metformin and myoinositol: a powerful weapon to combat polycystic ovary syndrome

International Journal of Reproduction Contraception Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Polycystic ovary syndrome (PCOS) affects up to 13% of women reproductive age, causing symptoms like menstrual irregularities, insulin resistance, and infertility. Insulin resistance is the root cause PCOS. Metformin, an insulin-sensitizing drug, Myo-inositol, a natural compound that enhances ovarian function also sensitising agent, have both shown benefits in PCOS management. When combined, these agents act synergistically, results improved cycle regularity, reduction hyperandrogenic symptoms, enhancement fertility outcomes. Recent clinical evidence supports this dual approach, its approval for PCOS-related infertility treatment India, along with endorsement by FOGSI, underscores effectiveness as promising therapeutic option

Language: Английский

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Association between METS-IR and female infertility: a cross-sectional study of NHANES 2013–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 28, 2025

Background Obesity and metabolic syndrome are significant contributors to infertility in women closely associated with insulin resistance (IR). The score for (METS-IR) is a new, non-insulin-based fasting index used measure IR. However, the potential of METS-IR as predictive indicator female risk has not been established. This study aimed explore association between infertility. Methods cross-sectional data from National Health Nutrition Examination Survey (NHANES) 2013 2018. We conducted multivariate logistic regression, restricted cubic spline (RCS), threshold effect analyses investigate relationship Results According self-reported data, 188 (12.20%) participants were classified infertile. A significantly higher proportion elevated found have Multivariable regression analysis revealed that was increased infertility, irrespective independent variable by continuous variables or tertiles fully adjusted model (Model 3, variable: OR = 1.02, 95% confidence interval (CI):1.01–1.04, p 0.005; tertile 3 vs. 1: 2.00, CI 1.21–3.28, 0.0128, trend =0.0126). RCS indicated linear correlation ( 0.121), further supported this 0.136). Moreover, above inflection point 32.94, increasing level < 0.0001). Conclusion Our results suggest high levels positively among reproductive-aged females United States.

Language: Английский

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Effects of Obesity on Female Fertility: Mechanisms, Clinical Consequences and Management Strategies

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1646 - 1653

Published: Jan. 1, 2025

Language: Английский

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Post-traumatic stress disorder, metabolic syndrome, diabetic distress, and vitamin B1/benfotiamine

INTERNATIONAL NEUROLOGICAL JOURNAL, Journal Year: 2025, Volume and Issue: 21(1), P. 96 - 107

Published: March 20, 2025

A person with post-traumatic stress disorder (PTSD) is more likely to develop metabolic syndrome (MetS), depression, and diabetic distress. It also raises the risk of cardiometabolic neurodegenerative diseases (NDD). At same time, type 2 diabetes mellitus MetS can cause development core neurosis-like psychiatric symptoms characteristic PTSD. Chronic associated cardiovascular diseases, diabetes, NDD. More people think that mitochondrial dysfunction, peripheral/central chronic low-grade inflammation (CLGI), oxidative are main causes these diseases. Pathophysiological processes link them together. To make things better for patients, interventions aim control CLGI may be better, following ideas precision medicine. Deficiency certain biofactors, in particular, vitamin B1, an increased MetS, Targeted effects on CLGI, stress, metabolism disorders suggest use antioxidants, particularly B1/benfotiamine (BFT), have a positive effect not only course comorbid but manifestations Exogenous or BFT, corrects thiamine status disorders. BFT exhibits potent animal models NDD, stress-induced anxiety, aggression, depression. Thus, considered potentially safe cost-effective drug treatment many central nervous system Despite its aspects, therapeutic potential remains limited, as beneficial require high doses over long period time. Dibenzoylthiamine, lipophilic form has been shown anti-inflammatory antioxidant at much lower than both vitro vivo. However, preclinical clinical studies needed sure viability dibenzoylthiamine. This review pays extra attention analysis features biological role mechanism action, especially impact glucose function, state neuroinflammation, how dibenzoylthiamine protect neurons. We conducted search Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. The keywords used were “thiamine”, “benfotiamine”, “dibenzoylthiamine”, “post-traumatic disorder”, “metabolic syndrome”, “diabetic distress”, “diabetes mellitus”. manual bibliography publications pinpoint research results eluded online search.

Language: Английский

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Nutrition for Preconception Health and Fertility

Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 14, 2025

Background:: The importance of preconception care is now widely recognised. Optimisation the lifestyle, nutrition, and health a couple not only affects chances conception successful pregnancy but also resulting offspring. Currently, limited data reinforce further research examining role individual nutrients. complex interactions that these nutrients have with each other resultant effect on fertility should be focus for future investigation. Modifiable risk factors such as alcohol, caffeine, body mass index optimised prior to attempting conceive. New personalised advice. Summary:: This review examines roles macronutrients, micronutrients, lifestyle in reproductive health. Raising awareness nutrition hormone balance, gamete development, implantation, paramount. applies all healthcare professionals who come into contact people child-bearing age, well general public.

Language: Английский

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Association between the dietary index for gut microbiota and female infertility: a cross-sectional study of NHANES 2013–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Infertility poses a substantial societal and economic burden; however, current preventive strategies are limited. Recently, the relationship between gut microbiota infertility has garnered increasing attention. The dietary index for (DI-GM) is new that reflects diversity of microbiota. However, its association with female remains unclear. This cross-sectional study included 3,053 women aged 18-45 years from National Health Nutrition Examination Survey (NHANES) database 2013 2018. was defined based on responses to questionnaire reproductive health. DI-GM score calculated by averaging intake two 24-h recall interviews. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses were used investigate infertility. Based self-reported data, 370 participants (12.12%) classified as infertile. A higher proportion lower scores experienced Multivariable regression analysis indicated negative risk infertility, regardless whether independent variable analyzed continuous or in quartiles fully adjusted model (Model 3, variable: OR = 0.89, 95% confidence interval (CI): 0.80-0.98, p 0.025; Q4 vs. Q1: 0.63, CI 0.42-0.94, 0.032, trend 0.013). RCS curves demonstrated non-linear risk. Subsequent corroborated robustness these findings. These findings suggest females, associated

Language: Английский

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Association between cardiometabolic index and infertility risk: a cross-sectional analysis of NHANES data (2013–2018)

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 2, 2025

The cardiometabolic index (CMI), a novel measure of obesity that integrates lipid profiles and indicators abdominal adiposity, has emerged as promising marker metabolic health. However, its relationship with infertility remains largely unexplored. Using data from the National Health Nutrition Examination Survey (NHANES) conducted between 2013 2018, this study investigated potential association CMI risk. We utilized weighted multivariate logistic regression to examine employed restricted cubic spline model explore non-linear relationships. Interaction tests subgroups analyses were assess heterogeneity across different subgroups. analysis included nationally representative cohort 1,142 women. After controlling for confounders, positive was identified risk (OR: 1.47; 95% CI: 1.05-2.06; p = 0.028). revealed (p 0.0109), an inflection point at value 0.341. Our findings provides evidence among U.S. adults. These results suggest could serve simple effective surrogate assessment, offering valuable insights reproductive health management.

Language: Английский

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One-carbon metabolism, insulin resistance, and fecundability in a Singapore prospective preconception cohort study

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Metabolic mediators of the overweight’s effect on infertility in women with polycystic ovary syndrome

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 9, 2025

Women with polycystic ovary syndrome (PCOS) often experience infertility, potentially mediated by metabolic factors altered elevated body mass index (BMI). While triglycerides (TG), low-density lipoprotein (LDL), high-density (HDL), and fasting blood sugar (FBS) are known mediators in the BMI-infertility relationship, extent of their mediation effects remains unquantified prior studies. This study quantifies effect these factors. We conducted a cross-sectional on 669 women diagnosed PCOS at tertiary hospital Tehran, Iran, from 2021 to 2023. Data BMI, TG, LDL, HDL, FBS were collected, infertility defined as inability conceive after 12 months unprotected intercourse. Mediation analysis was performed using Karlson Holm Breen (KHB) method, adjusting for age. Higher BMI associated increased levels decreased all which (except LDL) linked infertility. revealed that age, significantly association, accounting 52.98%, 79.19%, 49.7% effect, respectively. Our identified significant link, over half association through Targeting improvements may help reduce risk this population.

Language: Английский

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