Prognostic value of neutrophil-lymphocyte ratio in gastroenteropancreatic neuroendocrine neoplasm: a systematic review and meta-analysis
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19186 - e19186
Published: April 7, 2025
Purpose
A
high
neutrophil-to-lymphocyte
ratio
(NLR)
might
be
connected
with
an
unfavorable
tumor
prognosis.
We
sought
to
conduct
a
meta-analysis
of
published
studies
exploring
the
prognostic
value
NLR
in
patients
gastroenteropancreatic
neuroendocrine
neoplasm
(GEP-NEN).
Methods
have
referred
PRISMA
2020
for
Abstracts
checklist
and
registered
our
review
at
International
Prospective
Register
Systematic
Reviews
(registration
number
CRD42020187679).
The
PubMed,
Embase,
Web
Science
databases
were
screened
using
words
like
‘neutrophil
lymphocyte
ratio’,
‘neuroendocrine
tumors’,
others
up
July
2024.
In
study,
we
evaluated
significance
on
overall
survival
(OS),
recurrence-free
(RFS),
progression-free
(PFS)
GEP-NEN.
Subgroup
analysis
conducted
identify
origins
heterogeneity
examine
impact
factor
grouping.
Results
gathered
18
cohorts
2,995
cases.
All
included
quality,
Newcastle
Ottawa
Scale
(NOS)
scores
ranging
from
6
8.
pooled
revealed
that
higher
related
worse
OS
(hazard
(HR):
4.59,
95%
confidence
interval
(CI)
[3.35–6.29],
p
<
0.00001)
poor
RFS
(HR:
4.05,
CI
[2.78–5.90],
race,
sites,
therapy
showed
good
predictive
significance,
however,
is
not
effective
predicting
time
non-operative
patients.
Conclusion
This
predicted
OS,
RFS,
PFS
GEP-NEN
can
used
as
promising
predictor.
Language: Английский
A CECT-Based Radiomics Nomogram Predicts the Overall Survival of Patients with Hepatocellular Carcinoma After Surgical Resection
Peng Zhang,
No information about this author
Yue Shi,
No information about this author
Maoting Zhou
No information about this author
et al.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1237 - 1237
Published: May 19, 2025
Objective:
The
primary
objective
of
this
study
was
to
develop
and
validate
a
predictive
nomogram
that
integrates
radiomic
features
derived
from
contrast-enhanced
computed
tomography
(CECT)
images
with
clinical
variables
predict
overall
survival
(OS)
in
patients
hepatocellular
carcinoma
(HCC)
after
surgical
resection.
Methods:
This
retrospective
analyzed
the
preoperative
enhanced
CT
data
202
HCC
who
underwent
resection
at
Affiliated
Hospital
North
Sichuan
Medical
College
(Institution
1)
June
2017
2021
Nanchong
Central
2)
2020
2022.
Among
these
patients,
162
Institution
1
were
randomly
divided
into
training
cohort
(112
patients)
an
internal
validation
(50
7:3
ratio,
whereas
40
2
assigned
as
independent
external
cohort.
Univariate
multivariate
Cox
proportional
hazards
regression
analyses
performed
identify
risk
factors
associated
OS
Using
3D-Slicer
software,
tumor
lesions
manually
delineated
slice
by
on
non-contrast-enhanced
(NCE)
CT,
arterial
phase
(AP),
portal
venous
(PVP)
generate
volumetric
regions
interest
(VOIs).
Radiomic
subsequently
extracted
VOIs.
LASSO
analysis
employed
for
dimensionality
reduction
feature
selection,
culminating
construction
signature
(Radscore).
models,
including
model,
radiomic–clinical
developed
prediction.
performance
models
assessed
via
concordance
index
(C-index)
time–ROC
curves.
optimal
model
further
visualized
nomogram,
its
accuracy
evaluated
calibration
curves
decision
curve
(DCA).
Finally,
interpreted
Shapley
additive
explanations
(SHAP).
Results:
revealed
BCLC
stage,
albumin–bilirubin
(ALBI),
NLR–PLR
score
predictors
three
exhibited
highest
performance,
C-indices
0.789,
0.726,
0.764
training,
cohorts,
respectively.
Furthermore,
showed
1-year
3-year
AUCs
0.837
0.845
cohort,
0.801
0.880
0.773
0.840
Calibration
DCA
demonstrated
model’s
excellent
applicability.
Conclusions:
combining
CECT
provides
accurate
prediction
is
beneficial
clinicians
developing
individualized
treatment
strategies
HCC.
Language: Английский
Research progress on the influence of traditional Chinese medicine on tumor microenvironment therapy
Kun Gao,
No information about this author
Yang Cao,
No information about this author
Zixin Ning
No information about this author
et al.
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 14, 2024
More
and
more
attention
has
been
paid
to
the
tumor
microenvironment.
The
occurrence,
development,
metastasis,
drug
resistance
of
are
closely
related
At
same
time,
application
traditional
Chinese
medicine
(TCM)
in
prevention
treatment
attracted
due
its
regulatory
effect
on
cells
holistic
view
multitarget
TCM
make
it
very
suitable
for
regulation
This
article
will
review
current
research
status
molecular
mechanism
microenvironment
from
three
aspects:
can
reverse
inhibitory
phenotype
immune
cells,
enhance
response
clinical
application.
Language: Английский
Prognostic Value of Systemic Inflammatory Markers and Scoring Systems in Predicting Postoperative 30-Day Complications and Mortality in Colorectal Cancer Surgery: A Retrospective Cross-Sectional Analysis
Annali Italiani di Chirurgia,
Journal Year:
2024,
Volume and Issue:
95(4), P. 636 - 647
Published: Aug. 20, 2024
Language: Английский
Efficacy and safety of surufatinib in the treatment of patients with neuroendocrine tumor: a real-world study in Chinese population
BMC Cancer,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 31, 2024
Neuroendocrine
tumors
(NETs)
are
rare
neoplasms
that
originate
from
peptidergic
neurons
and
neuroendocrine
cells.
Due
to
their
increasing
incidence,
effective
treatment
strategies
required.
Surufatinib,
a
novel
small-molecule
inhibitor
with
antiangiogenic
immunomodulatory
effects,
has
shown
promise
in
clinical
trials
for
advanced
NETs.
However,
the
efficacy
safety
of
surufatinib
influenced
by
multiple
factors,
there
is
currently
lack
sufficient
real-world
studies
explore
these
potential
influencing
factors.
Language: Английский