Atherogenic index of plasma and triglyceride-glucose index mediate the association between stroke and all-cause mortality: insights from the lipid paradox DOI Creative Commons

Jinhua Qian,

Qinjie Chi,

Chengqun Qian

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 10, 2025

The "lipid paradox" describes the counterintuitive observation that traditionally unfavorable lipid profiles may be associated with improved outcomes in stroke patients. Non-traditional markers such as atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) have been proposed to better reflect complex metabolic disturbances following stroke. This study aims investigate mediating role AIP TyG association between all-cause mortality elucidate potential mechanisms underlying paradox. cohort used data from China Health Retirement Longitudinal Study (CHARLS), including 10,220 participants enrolled 2011 2020, a maximum follow-up 10 years. were calculated baseline serum measurements. U-test, chi-square test, restricted cubic spline analysis (RCS), cox proportional hazards regression mediation model analyze relationship AIP, index, mortality. A total 1,421 deaths (13.90%) occurred during an average 9.21 Compared survivors, non-survivors older, had higher prevalence stroke, lower levels (P < 0.05), while showed no significant group difference. RCS revealed nonlinear mortality, but nonlinearity for AIP. Cox identified age, gender, marital status, smoking history, hypertension, diabetes, lung disease, highest quartile (Q4) independent predictors (all P 0.05). Notably, negative (HR = 0.87, 95% CI: 0.77-0.98),demonstrating paradox phenomenon. Furthermore, chain model, both (β=-0.03, 95%CI: -0.072 -0.002) (β=-0.016, -0.036 independently mediated manner. However, positive effect through (β 0.028, 0.003-0.066) offset this mediation, rendering overall insignificant. or jointly influence risk after demonstrates Moreover, significantly increases post-stroke risk. These findings highlight interplay glucose metabolism prognosis offer novel perspective management.

Language: Английский

Atherogenic index of plasma and triglyceride-glucose index mediate the association between stroke and all-cause mortality: insights from the lipid paradox DOI Creative Commons

Jinhua Qian,

Qinjie Chi,

Chengqun Qian

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 10, 2025

The "lipid paradox" describes the counterintuitive observation that traditionally unfavorable lipid profiles may be associated with improved outcomes in stroke patients. Non-traditional markers such as atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) have been proposed to better reflect complex metabolic disturbances following stroke. This study aims investigate mediating role AIP TyG association between all-cause mortality elucidate potential mechanisms underlying paradox. cohort used data from China Health Retirement Longitudinal Study (CHARLS), including 10,220 participants enrolled 2011 2020, a maximum follow-up 10 years. were calculated baseline serum measurements. U-test, chi-square test, restricted cubic spline analysis (RCS), cox proportional hazards regression mediation model analyze relationship AIP, index, mortality. A total 1,421 deaths (13.90%) occurred during an average 9.21 Compared survivors, non-survivors older, had higher prevalence stroke, lower levels (P < 0.05), while showed no significant group difference. RCS revealed nonlinear mortality, but nonlinearity for AIP. Cox identified age, gender, marital status, smoking history, hypertension, diabetes, lung disease, highest quartile (Q4) independent predictors (all P 0.05). Notably, negative (HR = 0.87, 95% CI: 0.77-0.98),demonstrating paradox phenomenon. Furthermore, chain model, both (β=-0.03, 95%CI: -0.072 -0.002) (β=-0.016, -0.036 independently mediated manner. However, positive effect through (β 0.028, 0.003-0.066) offset this mediation, rendering overall insignificant. or jointly influence risk after demonstrates Moreover, significantly increases post-stroke risk. These findings highlight interplay glucose metabolism prognosis offer novel perspective management.

Language: Английский

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