Journal of Chromatography B, Journal Year: 2024, Volume and Issue: 1250, P. 124378 - 124378
Published: Nov. 19, 2024
Language: Английский
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 727 - 727
Published: Jan. 23, 2025
Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Among individuals with type 1 diabetes mellitus (T1DM), 30–40% are at risk developing DKD. This review focuses on mechanistic processes, available and emerging biomarkers for diagnosing, monitoring, preventing DKD, as well treatment options targeted DKD patients. A literature search was conducted PubMed Scopus using specific keywords. Inclusion exclusion criteria were applied to select articles used this review. The highlights various mechanisms involved in progression more severe stages. Additionally, several have been identified, which aid diagnosing monitoring disease. Furthermore, numerous approaches being explored address underlying causes Advanced research exploring new medications remission; sodium-glucose cotransport (SGLT2) inhibitors finerenone, particular, gaining attention their novel renoprotective effects. a major complication diabetes, marked by complex multifactorial mechanisms. Thus, understanding these processes essential therapies potentially reverse progression. Biomarkers show promise early diagnosis progression, while current strategies underscore importance multifaceted approach.
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 20, 2025
Introduction Diabetic nephropathy (DN), a major complication of diabetes, presents with poor clinical outcomes and affects patients throughout their lifetime. α-Methyltryptophan (α-MT) is blocker the amino acid transporter. SLC6A14 also an inhibitor indoleamine 2,3-dioxygenase-1 (IDO1). Methods In this study, we employed nuclear magnetic resonance-based metabolomic approach to investigate therapeutic effects α-MT in db/db mouse model DN explore underlying molecular mechanisms. Results The results study demonstrated that significantly reduced urinary excretion albumin creatinine, improved kidney function, decreased renal fibrosis mice. Metabolomic analyses tissues urine samples indicated mice displayed increased activity enzyme IDO1, alongside pronounced metabolic disturbances. These disturbances are chiefly characterized by alterations metabolism, energy production pathways, membrane biochemical features, nicotinamide all which have been implicated mTOR signaling apoptotic pathways. Discussion Administration showed evidence IDO1 inhibition rectification dysfunctions concurrent suppression apoptosis. findings highlight potential as promising agent for diabetic nephropathy.
Language: Английский
Citations
1
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: March 18, 2025
Diabetic nephropathy (DN) is influenced by dysregulated adipokines, which play a key role in inflammation, immune responses, and lipid metabolism. However, the precise molecular mechanisms linking adipokine dysregulation, cell infiltration, metabolic reprogramming DN remain poorly understood. Celastrol, bioactive regulator, has been shown to mitigate renal immune-inflammatory damage inhibiting PI3K/Akt/NF-κB signaling pathway. Yet, its specific impact on adipokine-mediated responses metabolism unclear. This study aims elucidate interplay between target genes investigate how celastrol modulates these interactions. Gene expression profiles of patients were obtained from GEO datasets (GSE30122 GSE30528) analyzed for differentially expressed (DEGs) using limma package. set variation analysis (GSVA) was conducted assess pathways, while Mendelian randomization (MR) Pearson correlation evaluated association DEGs adipokines. Immune infiltration IOBR R package (MCP-counter xCell methods), followed MR DN-related responses. Celastrol identified SEA database. A total 70 intersecting identified. GSVA revealed that brown beige adipocyte differentiation pathways downregulated, adipocyte-related upregulated (p < 0.05). demonstrated adiponectin negatively associated with (OR = 0.77, P 0.005), whereas leptin 1.92, 0.016) resistin 1.43, 0.001) positively associated. Three genes, MAGI2, FGF9, THBS2 linked risk T infiltration. correlated 0.51, 6.7e-06), FGF9 -0.8, 2.2e-16) MAGI2 0.75, 1.3e-13) correlated. 22 including THBS2, Our findings reveal progression through adipokine-immune crosstalk, emerging as regulatory genes. These insights provide new avenues biomarker discovery therapeutic implications development DN.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156643 - 156643
Published: March 1, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1125 - 1125
Published: March 24, 2025
Objectives: The objective of this study was to examine the association between non-high-density lipoprotein cholesterol (non-HDL-C) high-density (HDL-C) ratio (NHHR) and chronic kidney disease (CKD) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods: This originated from a survey carried out Zhejiang Province, located eastern China, March November 2018. To explore relationship NHHR CKD, multivariable logistic regression model employed. dose-response assessed using restricted cubic spline (RCS) analysis, while generalized additive models (GAMs) were applied associations urinary albumin-to-creatinine (UACR) as well estimated glomerular filtration rate (eGFR). Subgroup analyses performed across various demographic clinical categories assess consistency NHHR-CKD association. optimal cutoff for CKD diagnosis, its predictive accuracy, comparison components HbA1c determined through receiver operating characteristic (ROC) curve analysis. Results: enrolled 1756 participants, including 485 individuals 1271 without CKD. Multivariable revealed significant positive each standard deviation (SD) increase linked 23% higher odds (OR = 1.23, 95% CI: 1.09-1.37) after adjusting potential confounders. When comparing quartiles, fully adjusted ORs Q2, Q3, Q4 1.29 (0.92-1.79), 1.31 (0.94-1.83), 1.87 (1.34-2.60), respectively, relative Q1 (p trend < 0.01). RCS analysis confirmed linear both sexes nonlinearity > 0.05). GAMs indicated correlation UACR (ρ 0.109, p 0.001) but no eGFR -0.016, 0.502). demonstrated consistent most subgroups, except 18-44 years age group, well-controlled glycemic non-alcohol drinking group ROC identified an 3.48 prediction, area under (AUC) 0.606 (95% 0.577-0.635). Notably, outperformed individual performance. Conclusions: link levels increased prevalence T2DM patients. may also serve complementary biomarker early detection, though further prospective studies are needed confirm value utility high-risk populations.
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(8), P. 973 - 973
Published: April 11, 2025
Diabetes mellitus (DM) has emerged as the most common cause of chronic kidney disease (CKD) and end-stage renal (ESRD) globally in recent years. Diabetic nephropathy (DN), or diabetic (DKD) that occurs a direct consequence DM, complex pathophysiological mechanisms, such various inflammatory processes genetic epigenetic factors, often accentuated by comorbid illnesses like hypertension dyslipidemia. Therefore, management DKD involves targeting these etio-pathological processes. Various medications with remarkable modifying properties have been introduced for treatment DN We update current future diagnostic therapeutic landscapes against this article.
Language: Английский
Citations
0
BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 18, 2025
Extensive evidence suggests that dyslipidemia is associated with endothelial dysfunction, oxidative stress, and inflammation, all of which can contribute to kidney dysfunction. The atherogenic index plasma (AIP) a novel marker lipid metabolism disorder, but its role in dysfunction diabetic individuals remains controversial. This study aims clarify the association AIP individuals. cross-sectional analyzed representative sample participants aged 20 years older from United States (n = 2,386, NHANES 2007-2018) Korea 698, KNHANES 2012). Weighted multivariate logistic regression analyses smoothed curve fitting were conducted investigate relationship between logarithmically transformed (lgAIP) multiple including albuminuria low estimated glomerular filtration rate (eGFR) Additionally, we interaction subgroup assess whether this remained consistent across different populations. We utilized receiver operating characteristic (ROC) curves compare diagnostic performance other indices for In both databases, higher lgAIP was significantly occurrence (NHANES: OR 7.69, 95%CI: 2.90-20.40; KNHANES: 6.00, 1.05-34.36) fully adjusted model. However, (95% CI) low-eGFR 1.22 (0.33, 4.53) database 2.50 (0.16, 38.62) database, indicating no statistically significant association. Subgroup analysis revealed influenced by age BMI stratification (p < 0.05). Compared indicators, appears be more precise discriminatory predicting Our findings highlight strong Future research should explore mechanisms underlying relationship. Not applicable.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 25, 2024
Diabetic kidney disease (DKD) is a global and severe complication that imposes significant burden on individual health, families, society. Currently, the main treatment approaches for DKD include medication, blood glucose control, protein-restricted diet, pressure management, all of which have certain limitations. Exercise, as non-pharmacological intervention, has attracted increasing attention. This review introduces mechanisms clinical evidence exercise DKD, proposes potential prescriptions. Exercise can improve stability related to renin-angiotensin-aldosterone system (RAAS), reduce renal oxidative stress inflammation, enhance crosstalk between muscle kidneys, endothelial cell function. These contribute comprehensive improvement DKD. Compared traditional methods, several advantages, including safety, effectiveness, no side effects. It be used an adjunct therapy management. Despite evident benefits in there still lack large-scale, long-term randomized controlled trials provide more develop guidelines Healthcare professionals should actively encourage patients personalized plans based circumstances.
Language: Английский
Citations
2
Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)
Published: Jan. 1, 2024
Diabetic kidney disease (DKD) is one of the main microvascular complications diabetes mellitus, as well leading cause end-stage renal disease. Intestinal microbiota has emerged a crucial regulator its occurrence and development. Dysbiosis intestinal can disrupt mucosal barrier, abnormal immunological response, reduction in short-chain fatty acid metabolites, elevation uremic toxins, all closely related to development DKD. However, underlying mechanisms how metabolites influence onset progression DKD not been fully elucidated. In current review, we will try summarize microecological mechanism by focusing on three aspects: associated "gut-kidney axis," therapies targeted at managing microbiota, expecting provide theoretical basis for subsequent study relationship between homeostasis DKD, open an emerging perspective orientation treatment.
Language: Английский
Citations
1
The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(21)
Published: Nov. 12, 2024
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes that poses significant burden to global health. This investigation aims illustrate the functional role CD3D and its relevant mechanisms in DN progression. The pivotal genes between GSE47183 GSE30528 datasets were identified using bioinformatics methods. effects silencing on renal damage, inflammatory response, lipid metabolism validated mice. Furthermore, impacts knockdown cell viability, apoptotic rate, inflammation, levels investigated HK-2 cells under high glucose (HG) conditions. Additionally, RO8191 was employed investigate JAK/STAT pathway HG-treated cells. A total 5 focal through found be upregulated tissues from mitigated pathological damage kidneys, reduced decreased accumulation HG stimulation restrained increased apoptosis, promoted release cytokines, affected expressions hallmarks related cells; these changes partially abolished by knockdown. Mechanistically, downregulation ameliorated HG-induced injury blocking pathway. study underscores has potential as promising candidate treatment DN.
Language: Английский
Citations
0