Incidental Discovery of Persistent Müllerian Duct Syndrome in a Male With Bilateral Cryptorchidism and a Testicular Germ Cell Tumor: A Rare Case Report
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Cryptorchidism,
or
undescended
testes,
is
a
common
congenital
condition
that
significantly
increases
the
risk
of
testicular
malignancy,
particularly
germ
cell
tumors
(GCTs),
with
higher
in
left
testis.
Persistent
Müllerian
Duct
Syndrome
(PMDS)
rare
disorder
males,
where
structures
such
as
uterus
fallopian
tubes
are
present
despite
individual
having
Y
chromosome
and
male
external
genitalia.
The
concurrent
occurrence
cryptorchidism,
tumors,
PMDS
extremely
rare,
making
this
case
noteworthy.
We
report
24-year-old
history
bilateral
who
presented
an
abdominal
mass
intermittent
pain.
Imaging
studies
revealed
complex
suggestive
tumor.
During
surgery,
small
structure
resembling
was
discovered
excised
alongside
both
testes.
Histopathological
evaluation
confirmed
mixed
GCT
consisting
yolk
sac
tumor,
seminoma,
teratoma
arising
from
Additionally,
incidental
finding
uterine-like
consistent
PMDS.
Postoperatively,
patient
recovered
without
complications,
tumor
markers
normalizing
within
one
month.
Follow-up
imaging
physical
exams
showed
no
recurrence
at
six
months.
This
highlights
association
cryptorchidism
emphasizing
importance
multidisciplinary
approach
to
diagnosis,
treatment,
genetic
counseling,
regarding
fertility
associated
conditions.
Language: Английский
Testicular Atrophy and Growth Post Orchidopexy in Pediatric Patients: A Systematic Review
Faisal F. Aljadani,
No information about this author
Badr M. Rafi,
No information about this author
Leen M. Alghamdi
No information about this author
et al.
Journal of Pediatric Surgery Open,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100205 - 100205
Published: March 1, 2025
Language: Английский
Prenatal exposure to organochlorine pesticides and polychlorinated biphenyls and risk of testicular germ cell cancer later in life
The Science of The Total Environment,
Journal Year:
2025,
Volume and Issue:
970, P. 179054 - 179054
Published: March 1, 2025
Exposure
to
environmental
chemicals
during
fetal
development
may
increase
the
risk
of
testicular
germ
cell
cancer
(TGCC),
but
few
studies
have
tested
hypothesis.
We
focused
on
organochlorine
pesticides
(OCPs)
and
polychlorinated
biphenyls
(PCBs),
previously
investigated
in
relation
other
male
reproductive
health
outcomes.
conducted
a
nested
case-control
study
332
mother-son
pairs,
comprising
65
TGCC
cases
267
controls,
identified
from
Danish
Pregnancy
Screening
Registry
with
biobanked
serum
samples
collected
pregnant
women
1985-1995,
when
exposure
studied
was
relatively
high.
quantified
seven
OCPs
13
PCB
congeners
maternal
by
gas
chromatography
tandem
mass
spectrometry.
diagnoses
covariate
information
were
derived
nationwide
registries.
estimated
associations
between
individual
their
mixture
through
adapted
Cox
regression
quantile
g-computation
models.
Median
age
at
diagnosis
24.7
years.
In
main
analyses,
PCBs
showed
either
slightly
higher
risks
or
no
association
(close
Hazard
Ratios
(HR)
1.00),
confidence
intervals
overlapping
unity.
simultaneously
increasing
all
chemical
concentrations
one
quartile
resulted
(HR
1.11,
95
%
CI:
0.61;
2.05)
after
adjusting
for
confounders.
Sensitivity
analyses
investigating
tertiles
did
not
change
overall
pattern
results.
Prenatal
PCBs,
pregnancy
serum,
associated
later
TGCC.
Language: Английский
Cryptorchidism in Pediatrics and Adults
Shaban Memeti,
No information about this author
Marijan Kamilovski
No information about this author
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Cryptorchidism,
which
is
characterized
by
the
failure
of
one
or
both
testes
to
descend
into
scrotum,
presents
unique
challenges
in
pediatric
and
adult
populations.
It
essential
provide
early
diagnosis
intervention
children,
predominantly
through
orchiopexy,
with
laparoscopic
assistance
when
required,
preserve
fertility
reduce
risks
testicular
atrophy
germ
cell
cancer.
This
chapter
provides
an
in-depth
classification
cryptorchidism,
outlining
its
different
types
their
clinical
significance.
Cryptorchidism
includes
congenital
forms
like
true
undescended,
ectopic,
retractile,
as
well
acquired
ascending
testis.
emphasizes
contributions
genetic,
hormonal,
environmental
factors.
Diagnostic
techniques,
including
examination,
ultrasound,
diagnostic
laparoscopy,
surgical
adjunct
hormonal
treatments,
are
discussed.
In
adults,
cryptorchidism
frequently
goes
undetected
until
complications
appear,
malignancy,
impaired
spermatogenesis,
atrophy.
Management
decisions
involve
weighing
benefits
orchiopexy
against
those
orchiectomy.
The
highlights
significance
detection,
personalized
treatment
strategies,
long-term
follow-up
optimize
reproductive,
oncologic,
psychosocial
outcomes
throughout
lifespan,
emphasizing
a
multidisciplinary
approach.
Language: Английский
Cryptorchidism and testicular cancer in the dog: unresolved questions and challenges in translating insights from human studies
Sandra Soto‐Heras,
No information about this author
Lindsey Reinacher,
No information about this author
Bensen Wang
No information about this author
et al.
Biology of Reproduction,
Journal Year:
2024,
Volume and Issue:
111(2), P. 269 - 291
Published: May 13, 2024
Cryptorchidism,
the
failure
of
one
or
both
testes
to
descend
into
scrotum,
and
testicular
cancer
show
a
strong
correlation
in
dogs
humans.
Yet,
long-standing
medical
debates
persist
about
whether
location
undescended
directly
causes
humans
if
conditions
stem
from
common
origin.
Although
is
prevalent
disease
dogs,
even
less
known
its
cause
with
descent
this
species.
This
review
investigates
relation
between
these
two
disorders
drawing
insights
human
studies,
examines
key
biomarkers
identified
thus
far.
In
addition,
it
explores
potential
causal
links,
including
impact
temperature
on
maturing
cells
shared
genetic
Notably,
literature
reveals
significant
differences
men
reproductive
development,
histological
molecular
features
tumors,
prevalence
specific
tumor
types,
such
as
Sertoli
cell
tumors
cryptorchid
germ
These
disparities
caution
against
using
models
for
research
underscore
limitations
when
comparisons
The
paper
concludes
by
suggesting
initiatives
enhance
our
understanding
complex
interplay
cryptorchidism
dogs.
Language: Английский
Management of undescended testis
Seth Saylors,
No information about this author
Tolulope A. Oyetunji
No information about this author
Current Opinion in Pediatrics,
Journal Year:
2024,
Volume and Issue:
36(5), P. 554 - 561
Published: July 31, 2024
Purpose
of
review
Describe
why
this
is
timely
and
relevant.
Undescended
testis,
or
cryptorchidism,
a
common
diagnosis
encountered
by
pediatricians
that
requires
collaboration
with
pediatric
surgical
specialists
to
optimize
outcomes
for
these
patients.
As
topic
continues
be
heavily
researched,
it
imperative
understand
current
recommendations
emerging
management
options
including
new
techniques,
as
well
pitfalls
in
care
highlighted
the
literature.
Recent
findings
main
themes
literature
covered
article.
This
primarily
examines
practice
delays
referral,
unnecessary
imaging
being
key
factor
time
surgery.
briefly
discusses
undescended
testis
various
techniques
used
more
recently
proposed
laparoscopic
staged
traction
orchiopexy
(Shehata
technique).
The
ineffectiveness
hormonal
therapy
also
addressed.
Summary
describe
implications
clinical
research.
emphasizes
prompt
evaluation
facilitate
appropriately
timed
intervention,
which
plays
major
role
Identifying
patients
at
risk
delayed
referral
an
area
focus
improvement,
along
better
resource
utilization
fewer
imaging.
Familiarization
can
patient
education
provider
understanding
risks/benefits.
Language: Английский
Reproductive toxicology: keeping up with our changing world
Laura B. Miller,
No information about this author
Morgan B. Feuz,
No information about this author
Ralph G. Meyer
No information about this author
et al.
Frontiers in Toxicology,
Journal Year:
2024,
Volume and Issue:
6
Published: Oct. 11, 2024
Reproductive
toxicology
testing
is
essential
to
safeguard
public
health
of
current
and
future
generations.
Traditional
toxicological
male
reproduction
has
focused
on
evaluating
substances
for
acute
toxicity
the
reproductive
system,
with
fertility
assessment
as
a
main
endpoint
infertility
adverse
outcome.
Newer
studies
in
last
few
decades
have
significantly
widened
our
understanding
what
represents
an
event
toxicology,
thus
changed
perspective
constitutes
toxicant,
such
endocrine
disrupting
chemicals
that
affect
offspring
intergenerational
manner.
Besides
or
congenital
abnormalities,
outcomes
can
present
increased
likelihood
various
problems
offspring,
including
metabolic
syndrome,
neurodevelopmental
like
autism
cancer
predisposition,
among
others.
To
enable
toxicologic
accurately
represent
population,
designs
need
model
changing
population
characteristics
exposure
circumstances.
Current
trends
increasing
importance
human
include
paternal
age,
associated
decline
nicotinamide
adenine
dinucleotide
(NAD),
higher
prevalence
obesity,
both
which
are
factors
study
design
should
account
for.
In
this
article,
we
highlighted
some
limitations
standard
protocols,
expanding
assessed
by
genetic
epigenetic
sperm
parameters,
potential
recent
developments,
mixture
testing,
novel
animal
models,
vitro
systems
organoids,
multigenerational
well
silico
modelling,
machine
learning
artificial
intelligence.
Language: Английский
Association of endocrine disrupting chemicals with male reproductive health
Elsevier eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Language: Английский
Associations between maternal periconceptional exposure to PM2.5 and the risk of cryptorchidism: a case-control study of 4274
Yan Liu,
No information about this author
Yin-lin Chen,
No information about this author
Chengjun Yu
No information about this author
et al.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 29, 2024
Currently,
there
is
limited
evidence
regarding
the
association
between
prenatal
exposure
to
environmental
fine
particulate
matter
(PM2.5)
and
occurrence
of
cryptorchidism.
The
objective
this
study
was
evaluate
potential
correlation
PM2.5
likelihood
cryptorchidism
developing
in
offspring.
We
performed
a
1:1
case–control
study,
defining
cases
as
children
diagnosed
with
at
Children's
Hospital
Affiliated
Chongqing
Medical
University
from
2013
2017,
while
control
group
comprised
born
corresponding
years
who
did
not
have
any
birth
defects,
chromosomal
abnormalities,
had
only
trauma-related
treatments.
Between
2012
monthly
averages
PM2.5,
other
pollutants
(O3,
PM10)
temperature
were
gathered
based
on
geographical
coordinates
patients'
residences.
assessed
two
using
multivariate
logistic
regression
model,
sensitivity
analysis
conducted
assess
stability
model.
included
total
2137
matched
controls
2017.
Our
findings
revealed
that
positive
during
first
2
months
pregnancy
According
development
appears
be
associated
maternal
early
pregnancy.
Language: Английский
Хромосомная нестабильность у мальчиков с крипторхизмом
И.Ю. Юров,
No information about this author
О С Куринная,
No information about this author
Е.С. Карпачев
No information about this author
et al.
Педиатрия Восточная Европа,
Journal Year:
2024,
Volume and Issue:
12(4), P. 531 - 541
Published: Dec. 23, 2024
Введение.
До
настоящего
времени
хромосомная
нестабильность
у
мальчиков
с
крипторхизмом
не
изучалась.
Тем
менее
хаотизация
генома,
проявляющаяся
в
виде
хромосомной
нестабильности,
рассматривается
качестве
возможного
механизма
пороков
развития
и
нарушения
функционирования
различных
систем
организма
детей.
Цель.
Анализ
нестабильности
крипторхизмом.
Материалы
методы.
С
помощью
цитогенетических
молекулярно-цитогенетических
(флюоресцентная
гибридизация
in
situ
/
FISH)
методов
были
исследованы
лимфоциты
периферической
крови
30
врожденными
пороками
развития,
которых
наблюдался
крипторхизм.
Результаты.
В
ходе
цитогенетического
анализа
14
(47%)
была
выявлена
численных
структурных
аномалий,
а
также
особенностей
морфологии
поведения
хромосом.
Помимо
этого,
1
ребенка
обнаружена
структурная
аномалия
(46,ХУ,del(15)(q11.2q13)),
3
(10%)
–
соматический
мозаицизм
по
численным
аномалиям
(анеуплоидия
аутосом
гоносом:
45,Х[3]/46,ХY[37];
47,XY,+9[9]/46,XY[21];
45,Х[3]/46,ХУ[27]);
4
(13%)
хромосомный
гетероморфизм
(хромосомные
варианты:
46,ХУqh-,15ps+;
46,ХУ,9phqh;
46,ХУ,16qh-;
46,ХУ,1phqh,9phqh).
FISH
позволил
подтвердить
наличие
уточнить
ее
уровень
(долю
аномальных
клеток).
Среди
вышеуказанных
форм
ведущее
место
занимало
нарушение
морфологии,
структуры
хромосом
(преимущественно
морфологии/
7
мальчиков,
структурные
аномалии
5
анеуплоидия
2
мальчика).
Это
позволило
выдвинуть
предположения
о
том,
что
может
лежать
основе
возникновения
при
крипторхизме.
Заключение.
результате
проведенного
исследования
обнаружено,
распространена
среди
являться
одним
из
ключевых
элементов
патогенетического
каскада,
приводящего
к
этому
врожденному
пороку.
Materials
and
methods.
Using
cytogenetic
molecular
(FISH)
techniques,
blood
samples
(lymphocytes)
of
boys
with
congenital
malformations
including
cryptorchidism
was
tested.
Results.
A
analysis
revealed
chromosomal
instability
manifested
as
numerical
structural
abnormalities
well
chromosomes
morphology
behavior
features
(47%).
Additionally,
one
boy
demonstrated
a
imbalance
(46,XU,del(15)(q11.
2q13));
presented
somatic
mosaicism
by
anomalies
(autosomal
gonosomal
aneuploidy:
45,X[3]/46,XY[37];
45,X[3]/46,XY[27]);
heteromorphism
(chromosomal
variants:
46,XUqh-,15ps+;
46,XU,9phqh;
46,XU,16qh-;
46,XU,1phqh,9phqh).
allowed
confirming
the
presence
instability,
specifying
its
level
(abnormal
cells
proportion).
Among
above-mentioned
forms
leading
place
belonged
to
morphology,
chromosome
structure
disorders
(prevailing
morphology/behavior
boys,
aneuploidy
boys).
These
findings
hypothesizing
an
underlying
cause
cryptorchidism.
Conclusion.
This
study
that
is
common
among
may
represent
key
elements
pathogenetic
cascade
this
malformation.
Language: Русский