Interpretable Machine Learning reveals the Role of PANoptosis in the Diagnosis and Subtyping of NAFLD

Immunobiology, Journal Year: 2025, Volume and Issue: 230(3), P. 152909 - 152909

Published: April 26, 2025

Language: Английский

RANK–RANKL–OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9193 - 9193

Published: Aug. 24, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD)—and its worse form, metabolic-associated steatohepatitis (MASH), characterised by inflammation and damage—corresponds to the liver’s involvement in metabolic syndrome, which constitutes an economic burden for healthcare systems. However, biomolecular pathways that contribute are not completely clear. Abnormalities of bone metabolism frequent people affected disease, with reduced density increased risk fracture. Receptor activator NF-κB (RANK), receptor ligand (RANKL), osteoprotegerin(OPG) critical regulators metabolism, performing pleiotropic effects, may have potential disorders like MASLD, resulting a topic great interest intrigue. This narrative review aims investigate this role implications MASLD development progression hepatocellular carcinoma, represents worst complication.

Language: Английский

Prognosis of Cirrhotic Patients After Osteoporotic Femoral Neck Fracture

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6701 - 6701

Published: Nov. 7, 2024

: Osteoporotic hip fractures in cirrhotic subjects are associated with increased post-fracture mortality. Our aim was to identify unfavorable factors that were

Language: Английский