International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13196 - 13196
Published: Dec. 8, 2024
Diabetic
retinopathy
(DR)
is
a
leading
cause
of
blindness.
The
pathogenesis
diabetic
multifactorial
and
incompletely
understood.
Accordingly,
treatment
options
are
limited.
Recent
data
suggest
that
dopamine
might
play
role
in
the
development
progression
DR.
In
present
review,
we
discuss
these
comment
on
potential
modulation
management
this
devastating
microvascular
complication
diabetes
mellitus.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Introduction
Diabetic
retinopathy,
a
significant
trigger
for
blindness
among
working
age
individuals
with
diabetes,
poses
substantial
global
health
challenge.
Understanding
its
underlying
mechanisms
is
pivotal
developing
effective
treatments.
Current
treatment
options,
such
as
anti-VEGF
agents,
corticosteroids,
laser
photocoagulation,
and
vitreous
surgery,
have
their
limitations,
prompting
the
exploration
of
innovative
approaches
like
nanocapsules
based
drug-delivery
systems.
Nanoparticles
provide
promising
solutions
to
improve
drug
delivery
in
ocular
medicine,
overcoming
complexities
anatomy
existing
constraints.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 16, 2024
Background
The
disruption
of
circadian
rhythm
has
been
reported
to
aggravate
the
progression
diabetic
retinopathy
(DR).
Rest-activity
(RAR)
is
a
widely
used
method
for
measuring
individual
time
influencing
behavior.
In
this
study,
we
sought
explore
potential
association
between
RAR
and
risk
DR.
Methods
Diabetic
participants
aged
over
40
from
2011-2014
National
Health
Nutrition
Examination
Survey
(NHANES)
were
enrolled.
Data
wearable
device
ActiGraph
GT3X
was
generate
metrics,
including
interdaily
stability
(IS),
intradaily
variability
(IV),
most
active
10-hour
period
(M10),
least
5-hour
(L5),
Relative
amplitude
(RA).
Weighted
multivariable
logistic
regression
analysis
restricted
cubic
spline
conducted
examine
metrics
DR
risk.
Sensitivity
also
robustness
findings.
An
unsupervised
K-means
clustering
identify
patterns
in
IV
M10.
Results
A
total
1,096
enrolled,
with
prevalence
20.53%.
mean
age
62.3
years,
49.57%
being
male.
After
adjusting
covariates,
positively
associated
(β:
3.527,
95%CI:
1.371-9.073).
Compared
lowest
quintile
IV,
highest
had
136%
higher
odds
contrast,
M10
negatively
0.902,
0.828-0.982),
showing
48.8%
lower
Restricted
confirmed
that
these
associations
linear.
Meanwhile,
sensitivity
robustness.
identified
three
distinct
clusters,
Cluster
C
(high-IV,
low-M10)
significantly
comparing
(low-IV,
high-M10).
Conclusion
more
fragmented
peak
activity
level
might
be
an
increased
These
findings
indicate
maintaining
rhythmic
sleep-activity
behavior
mitigate
development
Further
research
necessary
establish
causality
understand
underlying
mechanisms,
focus
on
whether
interventions
designed
enhance
daily
increase
diurnal
can
effectively
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
Abstract
Based
on
our
previous
findings,
we
hypothesized
that
the
long
non-coding
RNA
RP11-502I4.3
may
be
involved
in
angiogenesis
associated
with
Diabetic
retinopathy
(DR).
We
investigated
role
of
DR
by
examining
its
regulation
vascular
endothelial
growth
factor
(VEGF).
assessed
differences
expression
between
normal
control
group
and
streptozotocin-induced
diabetic
rats
or
high
glucose
(HG)-stimulated
human
retinal
microvascular
cells
(HRMECs).
VEGF
was
measured
without
lentiviral
vectors
overexpressing
RP11-502I4.3.
analyzed
structural
functional
alterations
related
to
DR.
Our
analysis
revealed
lower
retinas
HG-stimulated
HRMECs
compared
conditions.
Overexpressing
resulted
decreased
levels.
exhibited
characterized
thinning
layer
thickness,
changes
inner
outer
nuclear
layers,
a
reduced
count
ganglion
cells,
presence
acellular
capillaries.
The
proliferative
activity,
migration
count,
tube
formation
ability
HG-treated
were
significantly
higher
than
those
group;
however,
these
delayed
overexpression.
downregulation
appears
promote
angiogenesis.
Jundishapur Journal of Natural Pharmaceutical Products,
Journal Year:
2024,
Volume and Issue:
19(4)
Published: Nov. 10, 2024
Background:
Limitations
in
drug
penetration
are
overcome
by
nanotechnology,
particularly
liposomes,
which
enhance
targeted
administration
of
ocular
medications.
Liposomes
can
augment
the
therapeutic
effects
curcumin,
a
natural
compound
with
positive
impacts
on
retina.
Treatments
for
eye
diseases
also
benefit
from
antibacterial
properties
ozonated
oil
liposomes.
Objectives:
This
study
aims
to
develop
and
evaluate
liposomes
loaded
curcumin
delivery
applications,
specifically
targeting
diabetic
retinopathy
(DR).
Methods:
Liposomal
nanoparticles
were
prepared
using
thin-film
hydration,
incorporating
phospholipids,
lecithin,
cholesterol,
oil,
curcumin.
We
assessed
physicochemical
including
particle
size,
zeta
potential,
encapsulation
efficiency
(EE),
morphology.
Drug
release
profiles
stability
studies
conducted.
Results:
The
optimized
showed
size
84.77
nm,
potential
-16.8
mV,
an
EE
94.73%.
formulation
exhibited
sustained
over
24
hours,
reaching
82.09%
cumulative
release.
Stability
indicated
minimal
changes
key
parameters
three
months
at
room
temperature.
Conclusions:
developed
liposomal
demonstrates
promising
characteristics
delivery,
potentially
enhancing
its
efficacy
DR.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13196 - 13196
Published: Dec. 8, 2024
Diabetic
retinopathy
(DR)
is
a
leading
cause
of
blindness.
The
pathogenesis
diabetic
multifactorial
and
incompletely
understood.
Accordingly,
treatment
options
are
limited.
Recent
data
suggest
that
dopamine
might
play
role
in
the
development
progression
DR.
In
present
review,
we
discuss
these
comment
on
potential
modulation
management
this
devastating
microvascular
complication
diabetes
mellitus.
