Association of Life’s Essential 8 and Life’s Simple 7 with metabolic-associated fatty liver disease in the United States DOI Open Access
Wei Fu, Guangyuan Cheng, Junlong Zhao

et al.

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 20, 2025

BACKGROUND Cardiovascular health (CVH) plays a crucial role in overall health, but its association with metabolic-associated fatty liver disease (MAFLD) remains unclear. AIM To investigate the relationship between CVH, measured using Life’s Essential 8 (LE8) and Simple 7 (LS7), prevalence of MAFLD. METHODS This cross-sectional study had sample 2234 individuals, representing approximately 120 million individuals United States. Baseline parameters were compared LE8 LS7 groups. Logistic regression models used to evaluate LE8, LS7, MAFLD, while taking into account confounding factors. The investigation employed restricted cubic splines non-linear associations. Subgroup analyses sensitivity studies performed strength reliability results. RESULTS Higher scores significantly associated decreased risk even after controlling for demographic, socioeconomic, clinical variables. demonstrated pattern, most dramatic reduction observed at higher CVH levels. Individual components, notably healthy behaviors factors, exhibited strong relationships indicated consistent across several demographics. Sensitivity tests utilizing other MAFLD definitions validated robustness findings. CONCLUSION adherence criteria, as by scores, is lower These results emphasize need advance control avoid

Language: Английский

Association of Life’s Essential 8 and Life’s Simple 7 with metabolic-associated fatty liver disease in the United States DOI Open Access
Wei Fu, Guangyuan Cheng, Junlong Zhao

et al.

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 20, 2025

BACKGROUND Cardiovascular health (CVH) plays a crucial role in overall health, but its association with metabolic-associated fatty liver disease (MAFLD) remains unclear. AIM To investigate the relationship between CVH, measured using Life’s Essential 8 (LE8) and Simple 7 (LS7), prevalence of MAFLD. METHODS This cross-sectional study had sample 2234 individuals, representing approximately 120 million individuals United States. Baseline parameters were compared LE8 LS7 groups. Logistic regression models used to evaluate LE8, LS7, MAFLD, while taking into account confounding factors. The investigation employed restricted cubic splines non-linear associations. Subgroup analyses sensitivity studies performed strength reliability results. RESULTS Higher scores significantly associated decreased risk even after controlling for demographic, socioeconomic, clinical variables. demonstrated pattern, most dramatic reduction observed at higher CVH levels. Individual components, notably healthy behaviors factors, exhibited strong relationships indicated consistent across several demographics. Sensitivity tests utilizing other MAFLD definitions validated robustness findings. CONCLUSION adherence criteria, as by scores, is lower These results emphasize need advance control avoid

Language: Английский

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