Association between non-neoplastic bladder diseases and bladder cancer risk: insights from Mendelian randomization studies DOI
Yi Zhang,

Rongkang Li,

Shaohua Zhang

et al.

Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Purpose Our aim is to explore the relation between non-neoplastic bladder diseases and cancer (BC) from a genetic level utilizing Mendelian randomization (MR). Methods Single nucleotide polymorphisms (SNPs) related cystitis, stones, neuropathic were gathered IEU genome-wide association studies database. Quality control on SNPs was performed via stringent screening criteria. The BC risk evaluated using inverse-variance weighted, MR-Egger, weighted median, simple mode, mode methods. Cochran’s Q test conducted assess heterogeneity of SNPs; in addition, MR-Egger intercept employed examine horizontal pleiotropy SNPs. Exposure outcomes validated validation Finally, used as exposure outcome evaluate reverse causality. Results showcased that genetically predicted cystitis significantly correlated raised (inverse-variance weighted: odds ratio [95%] = 1.1737 [1.0317, 1.3352], P .0149), consistent with cohort MR analysis. Nevertheless, no causal found stone (P > .05). In this study, sensitivity analysis indicated or pleiotropy. Conclusion study presents proof genetic-level increased risk, while stones do not show similar associations.

Language: Английский

Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Wenhua Li, Suya Ma, Yulong Tian

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with poorly understood etiology. Recent studies have suggested that metabolic dysregulation might be linked to the development of ASD; however, causal relationships remain unclear. This study aimed investigate association between these factors using two-sample Mendelian randomization (TSMR). We conducted TSMR analysis assess relationship blood metabolites and ASD summarized GWAS data. The metabolite dataset from Canadian Longitudinal Study Aging included 1091 309 ratios 7824 European individuals. data Psychiatric Genomics Consortium comprised 18,381 cases 27,969 controls. Blood were set as exposures outcome. primarily used inverse-variance weighted method, supplemented by MR-Egger, median, simple mode, mode methods. also sensitivity analyses confirm robustness. Replication, confounding, reserve performed verify causation. Additionally, pathway network pharmacology explore potential mechanisms. identified 55 known including 13 10 unknown associated ASD. our pathways, among which tryptophan metabolism was most notable (p = 0.0388). Gene Ontology functional Kyoto Encyclopedia Genes Genomes highlighted crucial such cellular glucuronidation, glucuronosyltransferase activity, bile secretion, significance apical part cell. Our findings indicate dodecenedioate, methionine sulfone, cysteine alanine ratio proline glutamate an impact on These results enhance understanding pathways involved in could lead new avenues for intervention prevention. Further research needed mechanisms underlying associations different populations.

Language: Английский

Citations

0
Assessing the role of statin therapy in bladder cancer: evidence from a Mendelian Randomization study DOI Creative Commons

Rongkang Li,

Guixiao Huang, Yunfei Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 19, 2024

Background Statins, which are medications that lower lipid levels, extensively used to decrease cardiovascular disease risk. Recently, the use of statins in cancer prevention has attracted considerable interest. However, it is still unclear whether a causal effect on bladder cancer. Methods The two-sample Mendelian Randomization (MR) was performed infer relationship between statin therapy (atorvastatin, simvastatin, and rosuvastatin) Single-nucleotide polymorphisms (SNP)-based genome-wide association studies (GWAS) were gathered from UK Biobank, involving 462,933 participants. We acquired summary-level genetic data European cohort 175,121 individuals. inverse variance weighted (IVW) method main analytical technique used, supplemented by MR-Egger, median, mode, simple mode estimate effects. Additionally, sensitivity analyses conducted verify robustness reliability our findings. Results Based IVW analysis, we identified significant rosuvastatin decreased risk cancer, with analysis inferring substantial reduction odds (OR = 3.52E-19, 95% CI: 5.48E-32–2.26E-06, p 0.005). In contrast, results did not reveal statistically genetically estimated atorvastatin 7.42E-03, 6.80E-06–8.084, 0.169) or simvastatin 0.135, 0.008–2.330, 0.168) Conclusion investigated link using among population. Our findings indicated predicted associated whereas no effects observed for use.

Language: Английский

Citations

3
Plasma proteins and coronary atherosclerosis: A Mendelian randomization study DOI Creative Commons

Henan Pan,

Zongkai Wu,

Yaran Gao

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(8), P. e41549 - e41549

Published: Feb. 21, 2025

Coronary atherosclerosis (AS) is a complicated and severe chronic pathological process that contributes to the basis of various cardiovascular diseases, which causes serious challenge global healthcare system. AS underlying physiopathological mechanism. Despite recent advances in research biomarkers therapeutic targets for AS, there remain significant limitations current targeted therapies AS. This study utilizes Mendelian randomization analysis leverage genetic variations order identify plasma proteins with causal relationships coronary Utilizing publicly available genome-wide association datasets, 4907 were assessed as exposure factors, being outcome variable. The primary analytical method employed was inverse variance weighted approach ensure robustness accuracy relationships. In addition, verify reliability results, we several complementary methods, including median, randomization-Egger, mode, simple mode approaches, thoroughly assess heterogeneity pleiotropy findings. To results exclude potential biases, leave-one-out sensitivity performed. Twenty analyzed identified ( P < .05), combined multiple bioinformatic analyses; among them, fibronectin 1 key target. These findings may provide new theoretical future drug development strategies.

Language: Английский

Citations

0
HDL cholesterol esters mediate the genetic link between sedentary behavior and urological cancers: Insights from mediation and validation analyses DOI Creative Commons
Junhao Chen, Junxian Zhao,

Jieming Zuo

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(18), P. e42369 - e42369

Published: May 2, 2025

This study explores the causal relationship between sedentary behavior and urological cancers, focusing on bladder cancer (BC), prostate cancer, kidney using Bayesian Mendelian randomization mediation analysis. A two-sample (MR) framework was employed, genetic variants as instrumental variables. multivariate MR assessed effects of behaviors (TV watching, computer use, driving) cancers. Sensitivity analyses (MR-Egger, MR-PRESSO, Cochran Q ) ensured robustness. Mediation analysis identified high-density lipoprotein (HDL) cholesterol ester levels a primary mediator, validated through meta-analysis. Prolonged TV watching significantly associated with increased BC risk (OR = 2.908; 95% CI 1.221–6.930; P .015). showed small HDL mediated 17.5% this effect. No relationships were observed use or driving confirmed robust findings without heterogeneity pleiotropy. increases risk, by levels. Sedentary is modifiable factor, highlighting importance lifestyle interventions in prevention.

Language: Английский

Citations

0
Novel Susceptibility Genes and Biomarkers for Obstructive Sleep Apnea: Insights from Genetic and Inflammatory Proteins DOI Creative Commons
Yang Zhao, Yinyin Jiang, Yaxi Wang

et al.

SLEEP, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Numerous observational studies link obstructive sleep apnea (OSA) to inflammatory proteins, yet the directionality of these associations remains ambiguous. Therefore, we aimed clarify potential gene-predicted proteins with OSA.

Language: Английский

Citations

2
Causal relationship between benign prostatic hyperplasia and prostate cancer: a bidirectional Mendelian randomization analysis DOI
Yi Zhang,

Guangyang Ou,

Rongkang Li

et al.

Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Objective Our aim is to explore the relation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) from a genetic level utilizing Mendelian randomization (MR). Methods The IEU genome-wide association studies database was surveyed for single nucleotide polymorphisms (SNPs) associated with BPH, PCa, PCa (validation cohort). Single were subjected stringent quality control based on rigorous screening criteria. BPH risk evaluated using inverse-variance weighted method (IVW), MR-Egger, simple mode, median, mode. Horizontal pleiotropy of assessed MR-Egger intercept test, while heterogeneity Cochran’s Q test. Reverse causality by evaluating as exposure outcome. A validation used verify Results increased significantly genetically predicted (IVW: OR [95% CI] = 1.3849 × 107 [2330, 8.2294 1010], P 2.0814 10−4). In reverse MR analysis, also 1.0011 [1.0003, 1.0019], 0.0031). findings consistent analysis results cohort. Sensitivity analyses indicated presence but no horizontal pleiotropy. Conclusion study presents proof significant bidirectional causal relationship an PCa. Key message Three research questions three bullet points What already known this topic? Observational suggest controversial allows investigation variants instrumental variables (IVs). does add? How might affect research, practice, or policy? Recognizing men diagnosed may benefit more protocols.

Language: Английский

Citations

1
Association between non-neoplastic bladder diseases and bladder cancer risk: insights from Mendelian randomization studies DOI
Yi Zhang,

Rongkang Li,

Shaohua Zhang

et al.

Postgraduate Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Purpose Our aim is to explore the relation between non-neoplastic bladder diseases and cancer (BC) from a genetic level utilizing Mendelian randomization (MR). Methods Single nucleotide polymorphisms (SNPs) related cystitis, stones, neuropathic were gathered IEU genome-wide association studies database. Quality control on SNPs was performed via stringent screening criteria. The BC risk evaluated using inverse-variance weighted, MR-Egger, weighted median, simple mode, mode methods. Cochran’s Q test conducted assess heterogeneity of SNPs; in addition, MR-Egger intercept employed examine horizontal pleiotropy SNPs. Exposure outcomes validated validation Finally, used as exposure outcome evaluate reverse causality. Results showcased that genetically predicted cystitis significantly correlated raised (inverse-variance weighted: odds ratio [95%] = 1.1737 [1.0317, 1.3352], P .0149), consistent with cohort MR analysis. Nevertheless, no causal found stone (P &gt; .05). In this study, sensitivity analysis indicated or pleiotropy. Conclusion study presents proof genetic-level increased risk, while stones do not show similar associations.

Language: Английский

Citations

1