Systemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis DOI Creative Commons
Yue Xiao, Jingya Gao, Yiyi Wang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 11, 2024

Background Psoriasis is commonly associated with metabolic dysfunction-associated steatotic liver disease, raising concerns about the hepatic effects of systemic treatments on psoriasis and its comorbid conditions. This study evaluates stiffness measurement (LSM) alterations identifies predictors abnormal LSM in psoriatic patients following treatments, including biologics methotrexate. Methods prospective cohort based PSOWCH database (Psoriasis Cohort West China Hospital). We initially included who had undergone sound touch elastography (STE), then recruited STE before treatment reassessed them after at least six months. Three subgroups were formed (interleukin inhibitors, tumor necrosis factor methotrexate), classifying post-treatment outcomes using threshold values 6.5 kPa 10.3 kPa. Results Among 52 patients, overall significantly increased during follow-up. Univariate regression analysis showed that age, gender, severity, arthritis status, current type not correlated cutoff In multivariate model, body mass index (BMI) was identified as a risk for ≥ (odds ratio [OR], 1.26; 95% CI, 1.04 to 1.60, P=0.031). Conclusions exploratory reveals LSM. However, significant association exists between BMI outcomes. These findings highlight critical importance management therapeutic interventions psoriasis.

Language: Английский

Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction DOI Creative Commons
Ángel Arturo López‐González, Emilio Martínez-Almoyna Rifá, Hernán Paublini

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 116 - 116

Published: Jan. 16, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic worldwide, with a multifactorial etiology. This study aims to evaluate associations between various sociodemographic variables, healthy habits, and stress risk scale values for MAFLD. A descriptive, cross-sectional was conducted on 16,708 Spanish workers assess how variables (age, gender, socioeconomic status), habits (smoking, Mediterranean diet adherence, physical activity), correlate from three MAFLD scales: index (FLI), hepatic steatosis (HSI), lipid accumulation product (LAP). All analyzed were associated scales. Among them, showing strongest (represented by odds ratio values) age activity. The profile an individual at higher elevated male, aged 50 or older, belonging lower levels (manual laborers), smoker, sedentary, low adherence diet, high scores.

Language: Английский

Citations

0
Treating Metabolic Related Fatty Liver Disease with Anxiety and Depression from Heart and Gallbladder Based on the Theory of “Zangfu Bietong” DOI

雅乔 周

Traditional Chinese Medicine, Journal Year: 2025, Volume and Issue: 14(01), P. 268 - 274

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanism of liver x receptor alpha in intestine, liver and adipose tissues in metabolic associated fatty liver disease DOI

Kaiwen Lei,

Runsheng Chen, Jian‐Xing Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142275 - 142275

Published: March 1, 2025

Language: Английский

Citations

0
Shared genetic architecture between metabolic dysfunction-associated steatotic liver disease and cardiometabolic traits comorbidities: a genome-wide pleiotropic and multi-omics study DOI Open Access
Xuan-Yu Wang, Qiong Lyu, Yangyang Zhang

et al.

Metabolism and Target Organ Damage, Journal Year: 2025, Volume and Issue: 5(2)

Published: April 21, 2025

Aim: While cardiometabolic disorders and metabolic dysfunction-associated steatotic liver disease (MASLD) frequently coexist, the genetic connections causes are not clearly understood. This study aimed to explore their shared architecture elucidate mechanisms driving comorbidity. Methods: Using summary statistics from genome-wide association studies (GWASs) on MASLD 29 traits (CMTs), we assessed correlation causality, identified loci, genes, pathways, cell types, tissues. Additionally, biological were uncovered using single-cell RNA sequencing data. Results: Significant correlations detected between 17 CMTs, encompassing diseases, glucose, lipids, adiposity, inflammatory markers, after adjusting for multiple testing (p .adjust < 0.05). Cross-trait analysis yielded a total of 166 risk SNPs (including those located in or near TRIB1 , LPL PNPLA3 GCKR PPARG ). Subsequent colocalization highlighted 73 loci associated with both rs429358 (APOE ) consistently prioritized HyPrColoc. Common genes (such as NPC1 MST1R TMBIM1 IRAK1BP1 L3MBTL3 RBM6 RGS19 ), significant enrichment cholesterol metabolism, glucose immune inflammation, long-term depression. Shared tissue-specific heritability was liver, adipose, artery, adrenal gland, brain tissue. Moreover, observed specific types (epicardial adipocytes, erythroid progenitor cells, hepatocytes, glial macrophages, monocytes, myeloid cells). The expressions APOE which showed significantly altered macrophages patients compared controls. Causality potential medications also explored. Conclusion: Multiple pathways contribute comorbidity disorders, lipid metabolism emerging critical factor. provides valuable insight into possible underlying offers directions future therapeutic innovations.

Language: Английский

Citations

0
Multipanel Approach including miRNAs, Inflammatory Markers, and Depressive Symptoms for Metabolic Dysfunction-Associated Steatotic Liver Disease Diagnosis during 2-Year Nutritional Intervention DOI Open Access
Ana Luz Tobaruela-Resola, José Ignacio Riezu‐Boj, Fermı́n I. Milagro

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1547 - 1547

Published: May 21, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), with a prevalence of 30% adults globally, is considered multifactorial disease. There lack effective non-invasive methods for accurate diagnosis and monitoring. Therefore, this study aimed to explore associations between changes in circulating miRNA levels, inflammatory markers, depressive symptoms hepatic variables MASLD subjects their combined potential predict the after following dietary intervention. Biochemical body composition, miRNAs psychological status 55 obesity overweight from FLiO were evaluated by undergoing 6-, 12- 24-month nutritional The highest accuracy values panels identified 24 months. A combination panel that included stiffness, high-density lipoprotein cholesterol (HDL-c), mass index (BMI), symptoms, triglycerides (TG) yielded an AUC 0.90. Another fat content, total (TC), miR15b-3p, TG, revealed 0.89. These findings identify biomarker including miRNAs, other metabolic predicting presence emphasize importance precision nutrition management sustained adherence healthy lifestyle patterns.

Language: Английский

Citations

3
Depression and the risk of non-alcohol fatty liver disease: Results from a cross-sectional study and a Mendelian randomization analysis DOI

Duoduo Lv,

Ning Han, Man Yuan

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 366, P. 300 - 307

Published: Aug. 29, 2024

Language: Английский

Citations

2
Patient Reported Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease DOI
Aurora Barberá, Trenton M. White, Anish Arora

et al.

Seminars in Liver Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide and can progress to serious complications, including metabolic steatohepatitis (MASH), cirrhosis, end-stage disease, hepatocellular carcinoma. Predisposing risk factors for MASH include obesity, type 2 diabetes, dyslipidemia, syndrome. Patients with often experience significant impairments in their health-related quality of life other patient-reported outcomes (PROs), particularly physical functioning domains, fatigue, vitality. Incorporating PROs offers valuable insights into patients' perspectives on symptoms, treatment efficacy, overall well-being, thereby guiding more holistic patient-centered care strategies. This review aims investigate utilization outcome measures (PROMs) context MASLD care, identify which PROMs are employed, summarize reported.

Language: Английский

Citations

2
Association between depression and liver function biomarkers among US cancer survivors in NHANES 2005–2020 DOI Creative Commons
Yanlong Li, Zhikang Ye,

Xuehong Ran

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Depression frequently comorbidities with cancer, adversely affecting survivors' quality of life. Liver dysfunction is also prevalent among cancer survivors. However, the association between these two conditions remains unclear. This study aimed to explore relationship depression and liver function biomarkers in US A cross-sectional was conducted utilizing data from National Health Nutrition Examination Survey (NHANES) 2005-2020. Cancer survivors were screened assessed using Patient Questionnaire-9 (PHQ-9), 18 included. Survey-weighted generalized linear models multiple covariables adjusted employed examine associations biomarkers. total 4118 included, representing a weighted population 21 501 237. After age, gender, race, marital status, education level, family income-to-poverty ratio, number types, 8 demonstrated positive correlations survivors, included alanine aminotransferase (ALT, OR = 1.007, 95% CI: 1.000 1.013), alkaline phosphatase (ALP, 1.006 [1.002, 1.010]), gamma glutamyl transferase (GGT, 1.004 [1.001, 1.007]), lactate dehydrogenase (LDH, [1.000, 1.009]), protein (TP, 1.040 [1.009, 1.072]), globulin (GLB, 1.060 [1.030, 1.091]), cholesterol (TC) high-density lipoprotein (HDL-C) ratio (1.162 [1.050, 1.286]), low-density (LDL-C) HDL-C (1.243 [1.012, 1.526]); while 4 other exhibited negative correlations, (0.988 [0.980, 0.997]), bilirubin (TBi, 0.501 [0.284, 0.883]), aspartate (AST) ALT (0.588 [0.351, 0.986]), albumin (ALB) GLB (0.384 [0.229, 0.642]). Following sensitivity analysis, 5 LDH, HDL-C, TBi, AST/ALT LDL-C/HDL-C lost their statistical significance for association. identified certain 7 Further research, particularly prospective longitudinal studies, warranted elucidate causal relationships potential improving management patients.

Language: Английский

Citations

2
The liver–brain axis in metabolic dysfunction-associated steatotic liver disease DOI
Anne Catrine Daugaard Mikkelsen, Kristoffer Kjærgaard, Anthony H.V. Schapira

et al.

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2
PAMK Ameliorates Non-Alcoholic Steatohepatitis and Associated Anxiety/Depression-like Behaviors Through Restoring Gut Microbiota and Metabolites in Mice DOI Open Access
Jianmei Yang,

Wanyi Ou,

Guiru Lin

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3837 - 3837

Published: Nov. 8, 2024

Objectives: Long-term Western diet-induced non-alcoholic steatohepatitis (NASH) can lead to liver cirrhosis and NASH-associated hepatocellular carcinoma, which are end-stage diseases. Meanwhile, NASH is associated with mental burden worsens as the disease progresses. Atractylodes Macrocephala Koidz (AMK) one of main ingredients Shenling Baizhu San, effect Polysaccharide from AMK ameliorates (PAMK), an important medicinal ingredient AMK, on anxiety/depression-like behaviors still unclear. Methods: This study investigated protective PAMK through a mice model. Results: showed that decreased concentrations TC, TG, serum AST ALT, improving glucose tolerance, reducing steatosis fibrosis. Moreover, expression IL-6, IL-1β, TNF-α, IL-18 MCP-1 could be reduced by significantly. Additionally, in hippocampus. 16S rRNA gene sequencing revealed diminished Firmicutes/Bacteroidetes ratio abundance Faecalibaculum_rodentium, increased Muribaculaceae. might related Pentose, glucuronate interconversions pathway carbohydrate enzymes (GH1, GH4). Serum metabolomics suggested PC (18:5e/2:0), (16:2e/2:0), Lysopc 20:4, (16:0/2:0), LPC 19:0 upregulated significantly after intervention, together enrichment carbon metabolism Citrate cycle pathways specially. Conclusions: potential prebiotic ameliorated mice, probably regulating lipid metabolites.

Language: Английский

Citations

1