Data on the Docking of Millet-Derived Secondary Metabolites as Multi-Target Ligands for Diabetes

Data in Brief, Journal Year: 2025, Volume and Issue: 59, P. 111290 - 111290

Published: Jan. 11, 2025

The deterioration of human health due to unhealthy lifestyle and dietary habits has led a worldwide increase in various metabolic diseases that significantly affect public health. Diabetes is one the most serious problems, caused by abnormal processes becoming increasingly common. According World Health Organisation (WHO) reports, significant proportion world's population suffers from these their incidence continues rise at an alarming rate. These disorders are characterised elevated blood sugar levels, which serve as warning sign for variety other problems. Factors contributing include high-fat diet, insufficient physical activity, genetic predisposition, lack exercise underlying diseases. mellitus, fast-growing chronic disease, insulin production pancreas or body's inability use action. Various strategies recommended nutrition experts manage this condition, including changes, exercise, low-carbohydrate low-fat diets intermittent fasting. In cases where measures prove insufficient, medication may be prescribed. However, development multi-drug therapies proven attractive field pharmacists they address several simultaneously. Despite promising effects therapies, high costs potential side associated with recently developed drugs necessitate alternative approaches. utilisation natural bioactive compounds plant extracts represents high-throughput strategy. This approach utilises network pharmacology screening methods identify ligands act inhibitors treatment complex, interconnected current investigation, we used molecular docking investigate secondary metabolites millet multi-target diabetes obesity.

Language: Английский

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Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: Common Molecular Mechanism and Therapeutic Targets

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(7)

Published: Sept. 3, 2024

ABSTRACT Diabetes mellitus (DM) and Alzheimer's disease (AD) rates are rising, mirroring the global trend of an aging population. Numerous epidemiological studies have shown that those with Type 2 diabetes (T2DM) increased risk developing dementia. These degenerative progressive diseases share some factors. To a large extent, amyloid cascade is responsible for AD development. Neurofibrillary tangles induce neurodegeneration brain atrophy; this chain reaction begins hyperphosphorylation tau proteins caused by beta (Aβ) accumulation. In addition to these processes, it seems alterations in glucose metabolism insulin signalling lead cell death reduced synaptic plasticity AD, before onset symptoms, which may be years away. Due substantial evidence linking resistance researchers coined name “Type 3 diabetes” characterize condition. We still know little about processes involved, even though current animal models helped illuminate links between T2DM AD. This brief overview discusses IGF‐1 disorders primary molecular pathways connect them. The presence GSK‐3β intriguing. proteins' association pancreatic β‐cell failure suggests they might therapeutic targets both disorders.

Language: Английский

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Praecitrullus fistulosus Fruit Extract Ameliorates Type II Diabetic Complications in Rats: In Silico, In Vitro, and In Vivo Investigation

Sciences of Pharmacy, Journal Year: 2025, Volume and Issue: 4(1), P. 1 - 8

Published: Jan. 13, 2025

This study explored the safety and antidiabetic potential of a hydroalcoholic extract Praecitrullus fistulosus fruits, along with qualitative quantitative phytochemical analyses. The effect was evaluated using in vitro methods, including α-amylase α-glucosidase inhibition assays, as well an vivo high-fat diet low-dose streptozotocin-induced diabetic model. Molecular docking studies were conducted to identify phytochemicals responsible for effects. fruit exhibited maximum 52.06% 58.10% enzymes, respectively, at concentration 100 µg/mL. also demonstrated significant (p < 0.001) dose-dependent oral doses 200 mg/kg 400 tested animals. In silico analysis revealed that α-tocopherol best pose, energy -8.2 kcal/mol. Based on results, it can be concluded contains effective controlling glucose levels. validates traditional use fruits managing diabetes.

Language: Английский

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Comprehensive review of animal models in diabetes research using chemical agents

Laboratory Animals, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Diabetes mellitus, characterized by insufficient insulin secretion and impaired efficacy, disrupts carbohydrate, protein, lipid metabolism. The global diabetic population is expected to double 2025, from 380 million, posing a significant health challenge. Most individuals fall into the type 1 or 2 categories, diabetes adversely affects various organs, such as kidneys, liver, nervous system, reproductive eyes. This review focuses on animal models of induced chemical agents, which are essential tools for understanding disease mechanisms, investigating complications, testing antidiabetic drugs. Models include those caused streptozotocin (STZ), alloxan, ferric nitrilotriacetate (Fe-NTA), dithizone, anti-insulin serum. Streptozotocin (STZ)-induced create destroying pancreatic beta cells. combination STZ with nicotinamide mimics phenotypes. Alloxan induces hyperglycemic state causing free radical formation that selectively destroys Fe-NTA dithizone also damaging Anti-insulin serum induce resistance hyperglycemia generating antibodies against receptors, leading condition similar diabetes. Each model has unique characteristics make it suitable different aspects research. These used understand pathogenesis diabetes, develop new treatment strategies, evaluate efficacy potential

Language: Английский

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Physical and Mental Disability in People with Diabetes

Published: Jan. 1, 2025

Language: Английский

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Rodent Models of Diabetic Neuropathy, Role of Calcium Homeostasis in Pain and KB-R7943 as a Potential Therapeutic

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2094 - 2094

Published: Feb. 27, 2025

Diabetic neuropathy (DN) is characterized by nerve damage as a consequence of diabetes mellitus. Diabetes causes high blood glucose and triglyceride levels, which destroy the vessels over time trigger DN. Peripheral most common type DN, encompasses broad range symptoms. One fourth patients with suffer from neuropathic pain, decreases their quality life puts them at risk for emotional disturbances depression. Finding an adequate therapy essential element in cure painful DN (PDN). Since pathophysiology this disease still needs to be elucidated, has led development various vivo diabetic models. Animal models not only provide insights into but also are significant drivers treatment assessment improvement. In review, we present major features commonly used chemically diet-induced PDN rodents progress date, utilized better understanding mechanism finding novel therapeutics. Considering role Ca2+ homeostasis review our recent research data on Na+/Ca2+ exchanger blocker KB-R7943, potential pain reliever rodent model

Language: Английский

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Trigonella foenum-graecum L. protects against renal function decline in a mouse model of type 2 diabetic nephropathy by modulating the PI3K-Akt-ERK signaling pathway

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Trigonella foenum-graecum L. (HLB) exhibits promising pharmacological properties for the treatment of type 2 diabetic nephropathy (DN). This study aims to enhance understanding HLB's pharmacodynamic effects and elucidate mechanisms underlying its therapeutic potential in DN. The HLB were initially evaluated a murine DN model through oral administration an aqueous extract HLB. primary bioactive constituents subsequently identified using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS). Network pharmacology analysis was integrated these data uncover molecular targets Key renal metabolites profiled untargeted metabolomics, followed by metabolic pathway enrichment conducted MetaboAnalyst 6.0 platform, which facilitated identification relevant pathways modulates Finally, quantitative real-time polymerase chain reaction (QRT-PCR) Western blot (WB) techniques employed validate expression levels key genes proteins, thereby confirming Animal experiments indicated that significantly improved blood glucose regulation function while reducing oxidative stress abnormalities lipid metabolism mice. A total 34 compounds 159 as active components metabolomics revealed 61 critical metabolites, among PI3K-Akt-ERK signaling pathway-known be involved diabetes-was highlighted crucial pathway. QRT-PCR WB analyses demonstrated upregulated MAPK1, MAPK3, AKT1, PI3K. These results suggest may alleviate modulating metabolism. Its are likely mediated pathway, along upregulation PI3K expression. lays groundwork further investigations into action

Language: Английский

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Nanotechnology in Diabetes Management: Advancements in PLGA-Based Drug Delivery

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

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1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101307 - 101307

Published: April 1, 2025

Language: Английский

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RNA-based diagnostic innovations: A new frontier in diabetes diagnosis and management

Diabetes and Vascular Disease Research, Journal Year: 2025, Volume and Issue: 22(2)

Published: March 1, 2025

Background/Objective: Diabetes mellitus (DM) remains a major global health challenge due to its chronic nature and associated complications. Traditional diagnostic approaches, though effective, often lack the sensitivity required for early-stage detection. Recent advancements in molecular biology have identified RNA molecules, particularly non-coding RNAs such as microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), promising biomarkers diabetes. This review aims explore role of RNA-based diagnosis, prognosis, management diabetes, highlighting their potential revolutionize diabetes care. Method: A comprehensive literature was conducted using electronic databases including PubMed, Scopus, Web Science. Articles published up 2024 were screened analyzed extract relevant findings related diagnostics Emphasis placed on studies demonstrating clinical utility, mechanistic insights, translational molecules. Results: Numerous species, miRNAs miR-375, miR-29, lncRNAs like H19 MEG3, exhibit altered expression patterns diabetic patients. These molecules are involved key regulatory pathways glucose metabolism, insulin resistance, β-cell function. Circulating detectable various biofluids, enabling non-invasive approaches. Emerging technologies, sequencing liquid biopsy platforms, enhanced specificity detection, fostering development novel tools personalized therapeutic strategies. Conclusion: hold significant promise advancing early risk stratification, monitoring Despite current challenges standardization validation, integration into routine practice could transform management, paving way precision medicine Further research multi-center trials essential validate these facilitate approval implementation.

Language: Английский

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