Exploring the causal relationship between constipation and ileus: Insights from bidirectional Mendelian randomization and genomic data analysis

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41509 - e41509

Published: Feb. 14, 2025

Constipation currently affects approximately 15% of the global population, and contemporary lifestyles are increasing its incidence every year. A significant number individuals with constipation also experience ileus, a common surgical emergency known for sudden onset rapid progression. However, intricate dynamics relationship between ileus not well understood. This study aimed to elucidate causal underlying mechanisms thereby advancing our understanding their interconnections. bidirectional 2-sample Mendelian randomization (MR) analysis was performed using IEU OpenGWAS database. Single nucleotide polymorphisms were used as instrumental variables determine causative association ileus. Additionally, we utilized eQTL datasets identify pertinent genes, conducted gene ontology Kyoto encyclopedia genes genomes enrichment analyses, constructed protein–protein interaction (PPI) networks via GeneMANIA database possible molecular pathways involved. Bidirectional MR revealed significantly elevated risk due (OR = 1.467, 95% CI 1.217–1.770, P < .001). Our investigation 6 that co-expressed in both ailments. Enrichment suggested potential roles these nucleic acid metabolism ribosomal biosynthesis, b-ureidopropionase 1 (UPB1) exhibiting most pronounced enrichment. Furthermore, PPI network highlighted several pivotal proteins genes. The findings this indicate existence nexus underscoring genetic susceptibility shared conditions. It has been postulated can perturb biochemical pathways, including UPB1 possibly serving key target. results novel basis provide foundation future experimental studies development customized preventive therapeutic approaches.

Language: Английский

Nutritional Support of Chronic Obstructive Pulmonary Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1149 - 1149

Published: March 26, 2025

Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These lead to airflow obstruction chronic symptoms. Additionally, increased risk infections exacerbates airway inflammation in patients. As consequence complex pathomechanisms difficulty treatment, among leading causes mortality both western countries developing world. Results: The management still challenge for clinicians; however, alternative interventions smoking cessation lifestyle changes from sedentary life moderate physical activity special attention diet may ameliorate patients' health. Here, we reviewed different dietary components supplements on conditions COPD. Conclusions: patients are continuously exposed heavy metals, which commonly present smoke polluted air. Meanwhile, they often experience significant nutrient deficiencies, affect detoxification these toxic metals. This turn can further disrupt nutritional balance interfering absorption, metabolism, utilization essential micronutrients. Therefore, awareness deliberate efforts should be made check levels micronutrients, ensuring adequate antioxidants, vitamin D, K2, magnesium, iron, particularly important reducing development limiting severity.

Language: Английский