Effects of germanium organic compound and α-lipoic acid on STZ-induced diabetes manifestations in rats DOI Creative Commons

Ya. V. Rozhkovskyi

Regulatory Mechanisms in Biosystems, Journal Year: 2024, Volume and Issue: 15(4), P. 962 - 969

Published: Nov. 18, 2024

Deep deteriorations accompany diabetes in all types of metabolism with an impact on functional activity and complications that are vital significance. Damage to the liver contributes worsening patient's state. Oxidative stress makes a pivotal contribution diabetes-induced disorders. The investigation niacin-oxyethylidene-diphosphonate germanate (MIGU-4) α-lipoic acid treatment, which both possessed antioxidative properties upon state rats streptozotocin induced diabetes, was aim investigation. Treatment MIGU-4 (25.0 mg/kg, i.p.) (50.0 started six weeks after induction by (65.0 administration.and performed daily for further weeks. results obtained revealed combined administration mg/kg) caused increase albumin decrease bilirubin when compared streptozotocin-treated rats. Administration reduction cholesterol triglycerides, low-density lipoproteins, while high-density lipoproteins increased. Besides, treatment reduced malone dialdehyde, increased glutathione content, superoxide dismutase catalase streptozotocin-diabetes. protective effect is more pronounced than alone. There ample scope investigations treating damage complex metabolic

Language: Английский

The role and mechanism of m6A methylation in diabetic nephropathy DOI
Lin-Jing Yan, Liang Guo

Life Sciences, Journal Year: 2025, Volume and Issue: 363, P. 123355 - 123355

Published: Jan. 6, 2025

Language: Английский

Citations

1
Diabetic Nephropathy: Pathogenesis, Mechanisms, and Therapeutic Strategies DOI

Shivangi Dwivedi,

Mukesh Singh Sikarwar

Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Diabetic nephropathy represents a predominant etiology of end-stage renal disease (ESRD) on global scale, significantly impacting the morbidity and mortality rates individuals with diabetes. The primary objective this analysis is to furnish comprehensive examination etiology, fundamental mechanisms, treatment modalities for DN. development DN stems from multitude factors, encompassing intricate interplay involving metabolic irregularities induced by hyperglycemia, alterations in hemodynamics, inflammatory responses, oxidative stress, genetic susceptibility. Principal mechanisms encompass generation advanced glycation end products (AGEs), activation protein kinase C (PKC), overexpression renin-angiotensin-aldosterone system (RAAS). These processes precipitate glomerular hyperfiltration, hypertrophy, eventually, fibrosis scarring parenchyma. Initially, hyperglycemia triggers mesangial proliferation thickening basement membrane incipient stages DN, subsequently leading progressive sclerosis tubulointerstitial fibrosis. Inflammatory cascades, notably cytokines like TGF-β NF-κB, play pivotal roles advancement fostering accumulation extracellular matrix Inflammation pathways, particularly those essential diabetic progression stimulating presence worsened dysfunctional mitochondria, contributes further injury via lipid peroxidation DNA damage. Current therapeutic approaches concentrate optimizing glycemic control, controlling hypertension, suppressing system. Among antihypertensive medications, ACE inhibitors angiotensin II receptor blockers are crucial decelerating advancement.

Language: Английский

Citations

4
Global and national public awareness and interest in glomerular diseases from 2004 to 2024 DOI Creative Commons

Suryanarayanan Balakrishnan,

Charat Thongprayoon,

Iasmina Craici

et al.

Frontiers in Nephrology, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 23, 2025

Background Glomerular diseases significantly impact global health. This study investigated public interest in five common glomerular diseases. Methods Google Trends™ were used to analyze search activity from January 2004 December 2024 for IgA nephropathy (IgAN), membranous glomerulonephritis (MN), focal segmental glomerulosclerosis (FSGS), lupus nephritis (LN), and diabetic (DN). Data retrieved both globally English-speaking countries, including the United States. Monthly yearly relative assessed compared. Results Globally, IgAN had highest average activity, followed by DN, FSGS, LN, MN. Both FSGS exhibited declining trends, while LN showed an upward pattern. MN DN experienced a modest decline before 2016, preceded slight increase. Among was predominantly concentrated primarily States, Kingdom, Canada, Australia, with States consistently ranking as leading country. For IgAN, MN, trends observed appeared align data. In contrast, exceeded levels, slightly lower than activity. most prominent North Dakota, Massachusetts, Delaware, respectively, saw peak West Virginia. Conclusion Public engagement has not uniformly grown, at least emphasizing need enhanced awareness efforts. Future analysis should prioritize terms predominant language of each

Language: Английский

Citations

0
Integrative analysis of mitochondrial and immune pathways in diabetic kidney disease: identification of AASS and CASP3 as key predictors and therapeutic targets DOI Creative Commons
Xin‐Xin Yu,

Yongzheng Hu,

Wei Jiang

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 23, 2025

Objectives Diabetic kidney disease (DKD) is driven by mitochondrial dysfunction and immune dysregulation, yet the mechanistic interplay remains poorly defined. This study aimed to identify key molecular networks linking pathways DKD progression, with a focus on uncovering biomarkers therapeutic targets.

Language: Английский

Citations

0
Fructus arctii mitigates diabetic nephropathy via the Apoh/PPAR-γ pathway DOI
Na Zhang,

Anhui Chen,

Yuwei Dong

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 181, P. 18 - 28

Published: March 7, 2025

Language: Английский

Citations

0
Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy DOI Creative Commons
Yang Liu, Rong Wu, Zhenlei Zhou

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 24, 2025

Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Mitochondrial dysfunction in the kidney caused by diabetes has previously been linked to pathogenesis DN. By mass spectrometry, we identified characteristic proteins DN from renal mitochondria mouse model. To identify core among them, Mendelian randomization (MR) analysis, microarray data validation, and drug-target interaction analysis were employed. MR found that 189 candidate targets had causal link with risk factors (estimated glomerular filtration rate (eGFR), urinary albumin excretion, serum creatinine). After systematic validated SLC25A16, CTNND1, C2CD2L, ALDH3A2, NEU1, APEH, CORO1A, NUDT19, NDUFA4L2 are promising druggability This study suggests feasibility using for drug target screening, provides potential insights into mitochondrial research, which may contribute further exploration.

Language: Английский

Citations

0
Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy DOI Creative Commons
Tao Wei, Yang Qin,

Xiaohui Lin

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, exerts substantial burden on healthcare systems globally. Emerging evidence highlights ferroptosis - an iron-dependent form cell death driven by lipid peroxidation and glutathione depletion as critical contributor to DN progression via oxidative stress, tubular injury, glomerular dysfunction. Despite increasing research interest, comprehensive synthesis trends mechanistic insights is lacking. This study integrated bibliometric analysis with review map the evolving landscape in DN, identify hotspots, propose future directions for therapeutic development. In total, 86 publications (2018-2023) were retrieved from Web Science Core Collection analyzed using CiteSpace VOSviewer. Co-occurrence networks, citation trends, keyword bursts examined delineate global contributions, collaborative emerging themes. Annual publication numbers surged 12-fold after 2020, China contributing highest proportion (60.4%), led institutions such Zhengzhou University. The United States America Germany showed high centrality networks. Key themes included peroxidase 4 (GPX4)-mediated antioxidant defenses, acyl-CoA synthetase long-chain family member (ACSL4)-mediated remodeling, iron dysregulation. Frontiers Endocrinology (nine articles) Free Radical Biology Medicine (highest count: 171) emerged pivotal platforms. Mechanistic analyses identified three defense axes (GPX4, FSP1/CoQ10, GCH1/BH4) type-specific vulnerabilities tubular, podocyte, endothelial cells. Preclinical agents, including ginkgolide B (GB) dapagliflozin, effectively restored homeostasis attenuated damage. Ferroptosis promising target yet its clinical translation remains infancy. Future efforts should prioritize large-scale trials, single-cell profiling, interdisciplinary integration bridge molecular precision therapies. provides roadmap advancing ferroptosis-targeted interventions emphasizing collaborations biomarker-driven strategies.

Language: Английский

Citations

0
Yangonin Attenuates Streptozotocin-induced Diabetic Nephropathy in Rats via Downregulating Oxidative Stress and Inflammatory Responses DOI
Zi-Rui Hao, Lin Li,

Youlan Gong

et al.

Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Background Diabetic nephropathy (DN) is a serious complication of both type 1 and 2 diabetes defined by progressive kidney damage and, ultimately, failure. The growing prevalence worldwide, coupled with lifestyle changes, has led to rise in the incidence DN, posing significant public health financial burden. Purpose This work aims assess therapeutic significance yangonin on DN an experimental rat model. Methods rats received 65 mg/kg streptozotocin (STZ) induce DN. were then treated for 12 weeks. After treatments had been completed, body weight changes blood glucose levels determined. dysfunction biomarkers, including creatinine, urea, uric acid, urea nitrogen (BUN), marker enzymes, assessed utilizing commercial assay kits. concentrations inflammatory cytokines oxidative stress-related biomarkers evaluated using renal tissues underwent histological study. Results treatment considerably elevated subsequent reduction rats. Furthermore, markers enzymes decreased effectively reduced response stress boosting anti-oxidant analysis results further confirmed efficacy against Conclusion current findings indicate that may mitigate rats, which highlights possesses potential serve as advantageous option

Language: Английский

Citations

0
Molecular mechanisms of diabetic nephropathy: A narrative review DOI
Tian Sun,

Yina Guo,

Yanting Su

et al.

Cell Biology International, Journal Year: 2024, Volume and Issue: 48(9), P. 1240 - 1253

Published: June 30, 2024

Abstract Diabetic nephropathy (DN) is the predominant secondary resulting in global end‐stage renal disease. It attracting significant attention both domestic and international research due to its widespread occurrence, fast advancement, limited choices for prevention treatment. The pathophysiology of this condition intricate involves multiple molecular cellular pathways at various levels. This article provides a concise overview processes involved development DN. discusses factors, such as signaling pathways, cytokines, inflammatory responses, oxidative stress, damage, autophagy, epigenetics. aim offer clinicians valuable reference DN's diagnosis, treatment, intervention.

Language: Английский

Citations

2
Continuous Glucose Monitoring: A Transformative Approach to the Detection of Prediabetes DOI Creative Commons
Xueen Liu, Jiale Zhang

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 5513 - 5519

Published: Nov. 1, 2024

Prediabetes, as an intermediary stage between normal glucose homeostasis and overt diabetes, affects estimated 720 million individuals worldwide, highlighting the urgent need for proactive intervention strategies. Continuous monitoring (CGM) emerges a transformative tool, offering unprecedented insights into glycemic dynamics facilitating tailored therapeutic interventions. This perspective scores clinical significance of even slightly elevated fasting blood levels critical role early intervention. CGM technology provides real-time, continuous data on concentrations, surpassing constraints conventional methods. Both retrospectively analyzed real-time systems offer valuable tools management, each with unique strengths. The integration routine care can detect indicators type 2 inform development personalized strategies, foster patient engagement empowerment. Despite challenges such cost effective utilization through training education, CGM's potential to revolutionize prediabetes management is evident. Future research should focus refining algorithms, exploring leveraging wearable artificial intelligence advancements optimize control well-being.

Language: Английский

Citations

2