Mitochondrial dysfunction in AMI: mechanisms and therapeutic perspectives

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 10, 2025

Acute myocardial infarction (AMI) and the ischemia-reperfusion injury (MI/RI) that typically ensues represent a significant global health burden, accounting for considerable number of deaths disabilities. In context AMI, percutaneous coronary intervention (PCI) is preferred treatment option reducing acute ischemic damage to heart. Despite modernity PCI therapy, pathological cardiomyocytes due MI/RI remains an important target affects long-term prognosis patients. recent years, mitochondrial dysfunction during AMI has been increasingly recognized as critical factor in cardiomyocyte death. Damaged mitochondria play active role formation inflammatory environment by triggering key signaling pathways, including those mediated cyclic GMP-AMP synthase, NOD-like receptors Toll-like receptors. This review emphasizes dual both contributors regulators inflammation. The aim explore complex mechanisms its profound impact on immune dysregulation. Specific interventions mitochondrial-targeted antioxidants, membrane-stabilizing peptides, transplantation therapies have demonstrated efficacy preclinical models.

Language: Английский

Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 20, 2024

The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development progression. This study aimed to explore the potential mediating role of IC causal relationship between GM thyroid (TC) using Mendelian randomization (MR) analysis. Data from genome-wide association studies (GWAS) encompassing 473 species, 731 types, TC were utilized. MR analysis identified nine species with significant relationships TC, mediated by 10 phenotypes such "Switched Memory AC," "IgD-CD38dim "EM DN (CD4-CD8-) AC." These findings suggest a complex interplay where specific mediate effects on risk. Sensitivity analyses confirmed robustness these results, no evidence horizontal pleiotropy. highlights mechanisms linking offering insights that could inform GM-based immunotherapeutic strategies IC-targeted interventions. However, further experimental research is needed validate pathways better understand underlying biological mechanisms.

Language: Английский