Associations of onset time, severity, and persistence of hypothyroxinemia with pregnancy outcomes: A retrospective study DOI Creative Commons
De‐Xiang Xu,

Xiayi Wang,

Xingyu Yang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Background Evidence regarding adverse pregnancy outcomes in pregnancies with hypothyroxinemia remains controversial, and the effect of onset time, severity, persistence has not been thoroughly investigated. This study aims to evaluate associations between respect hypothyroxinemia. Methods retrospective cohort included 51, 305 singleton who delivered at a tertiary hospital January 2017 December 2021. Thyroid function data clinical information were obtained through digital medical records. Participants categorized into euthyroid group according free thyroxine (FT4) thyrotropin (TSH) values first (gestational week 9-13) third trimester 32-36). Hypothyroxinemia was defined as FT4 < 10th gestational age-specific percentile combination TSH level within 10th-90th percentile. Pregnancy compared women euthyroidism The assessed using binary logistic regression crude adjusted models. Results Compared group, associated higher risk Cesarean delivery (adjusted odds ratio [aOR], 1.20, 95% confidence interval [CI]: 1.11-1.29), macrosomia (aOR, 1.25, 95%CI: 1.08-1.44), diabetes mellitus (GDM) 1.49, 1.36-1.63), increased levels decreasing. linked heightened 1.52, 1.40-1.66), 1.44, 1.27-1.73), pre-eclampsia 1.72, 1.38-2.14), hypertension 1.18-1.76), negatively correlated levels. Persistent an 1.50, 1.28-1.76) GDM 1.45, 1.19-1.76).  Conclusion revealed that both first- third-trimester macrosomia, However, relations pre-eclampsia, hypertension, varied by age when diagnosed

Language: Английский

Exosomes in the Diagnosis of Neuropsychiatric Diseases: A Review DOI Creative Commons
Song Wu,

Xin-miao Shang,

Meng Guo

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 387 - 387

Published: May 28, 2024

Exosomes are 30–150 nm small extracellular vesicles (sEVs) which highly stable and encapsulated by a phospholipid bilayer. contain proteins, lipids, RNAs (mRNAs, microRNAs/miRNAs, long non-coding RNAs/lncRNAs), DNA of their parent cell. In pathological conditions, the composition exosomes is altered, making potential source biomarkers for disease diagnosis. can cross blood–brain barrier (BBB), an advantage using in diagnosis central nervous system (CNS) diseases. Neuropsychiatric diseases belong to CNS diseases, many diagnostic markers have been identified neuropsychiatric Here, we review discuss application exosomal early accurate these Additionally, outline limitations future directions

Language: Английский

Citations

5
Associations of onset time, severity, and persistence of hypothyroxinemia with pregnancy outcomes: A retrospective study DOI Creative Commons
De‐Xiang Xu,

Xiayi Wang,

Xingyu Yang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Background Evidence regarding adverse pregnancy outcomes in pregnancies with hypothyroxinemia remains controversial, and the effect of onset time, severity, persistence has not been thoroughly investigated. This study aims to evaluate associations between respect hypothyroxinemia. Methods retrospective cohort included 51, 305 singleton who delivered at a tertiary hospital January 2017 December 2021. Thyroid function data clinical information were obtained through digital medical records. Participants categorized into euthyroid group according free thyroxine (FT4) thyrotropin (TSH) values first (gestational week 9-13) third trimester 32-36). Hypothyroxinemia was defined as FT4 < 10th gestational age-specific percentile combination TSH level within 10th-90th percentile. Pregnancy compared women euthyroidism The assessed using binary logistic regression crude adjusted models. Results Compared group, associated higher risk Cesarean delivery (adjusted odds ratio [aOR], 1.20, 95% confidence interval [CI]: 1.11-1.29), macrosomia (aOR, 1.25, 95%CI: 1.08-1.44), diabetes mellitus (GDM) 1.49, 1.36-1.63), increased levels decreasing. linked heightened 1.52, 1.40-1.66), 1.44, 1.27-1.73), pre-eclampsia 1.72, 1.38-2.14), hypertension 1.18-1.76), negatively correlated levels. Persistent an 1.50, 1.28-1.76) GDM 1.45, 1.19-1.76).  Conclusion revealed that both first- third-trimester macrosomia, However, relations pre-eclampsia, hypertension, varied by age when diagnosed

Language: Английский

Citations

0