Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health
Cells,
Journal Year:
2025,
Volume and Issue:
14(1), P. 36 - 36
Published: Jan. 2, 2025
Chronic
inflammation
is
increasingly
recognized
as
a
critical
factor
in
female
reproductive
health;
influencing
natural
conception
and
the
outcomes
of
assisted
technologies
such
vitro
fertilization
(IVF).
An
essential
component
innate
immunity,
NLR
family
pyrin
domain-containing
3
(NLRP3)
inflammasome
one
major
mediators
inflammatory
responses,
its
activation
closely
linked
to
oxidative
stress.
This
interaction
contributes
decline
oocyte
quality,
reduced
potential,
impaired
embryo
development.
In
ovarian
milieu,
stress
NLRP3
interact
intricately,
their
combined
effects
on
competence
are
significant.
The
aims
this
review
examine
these
molecular
mechanisms
explore
therapeutic
strategies
targeting
activity,
with
goal
enhancing
fertility
improving
clinical
health.
Language: Английский
Joint association of dietary and lifestyle oxidative balance score with infertility among reproductive-aged US female: a cross-sectional study
Human Fertility,
Journal Year:
2025,
Volume and Issue:
28(1)
Published: April 15, 2025
Infertility
affects
one
in
six
individuals
globally,
with
oxidative
stress-modifiable
through
diet
and
lifestyle-being
a
key
factor
female
infertility.
This
study
examines
associations
between
dietary/lifestyle
Oxidative
Balance
Scores
(OBS)
infertility
risk
reproductive-aged
women.
Using
2013-2018
NHANES
data
from
2,447
women
aged
20-44,
we
calculated
OBS
(16
dietary
4
lifestyle
components)
reflecting
antioxidant
vs.
pro-oxidant
exposure.
Higher
scores
indicate
dominance.
Weighted
logistic
regression
models
adjusted
for
sociodemographic
health
covariates
revealed
an
inverse
linear
relationship:
each
1-unit
increase
correlated
4.7%
lower
(95%
CI:
0.929-0.977,
p
<
0.001).
Women
the
highest
tertile
had
6.4%
reduced
odds
versus
tertiles
0.897-0.977,
=
0.003).
Joint
analyses
showed
higher
mitigated
among
low
OBS.
Results
remained
consistent
across
subgroups
sensitivity
analyses.
These
findings
underscore
potential
of
antioxidant-rich
diets
healthy
lifestyles
reducing
stress-related
infertility,
advocating
targeted
interventions
to
improve
reproductive
outcomes.
Language: Английский
Association between estimated glucose disposal rate and female infertility: a cross-sectional study
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 12, 2024
Insulin
resistance
(IR)
can
lead
to
infertility
in
women.
The
primary
objective
of
this
research
was
examine
how
estimated
glucose
disposal
rate
(eGDR)
correlates
with
women,
assessing
its
validity
as
an
indicator
IR.
Language: Английский
Total antioxidant capacity status in non-obese adolescent females with PCOS: a cross-section study
Middle East Fertility Society Journal,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Nov. 12, 2024
Abstract
Background
The
endocrine
disease
polycystic
ovarian
syndrome
(PCOS)
has
a
number
of
complications.
Teenagers
all
over
the
globe
are
becoming
increasingly
concerned
about
syndrome.
It
been
suggested
that
oxidative
stress
plays
significant
role
in
pathogenesis
PCOS.
Aim
purpose
present
work
was
to
estimate
total
antioxidant
capacity
(TAC)
non-obese
adolescents
and
decide
if
TAC
could
be
potential
marker
for
prediction
diagnosis
Methods
Serum
samples
were
collected
assess
levels
follicle
stimulant
hormone
(FSH),
luteinizing
(LH),
serum
lipids,
50
patients
with
PCOS
controls;
correlation
analysis
made
between
lipid,
hormonal
parameters,
TAC.
Results
Adolescents
had
significantly
lower
compared
controls
showed
higher
values
LH,
FSH,
LH/FSH
ratio.
There
negative
correlations
LH/FSH.
Linear
regression
revealed
statistically
LH
FSH
Conclusion
level
diminished
related
increase
So,
quantification
activity
value
assessment
cases
at
risk
development
PCOS,
suggesting
its
possible
regulating
sex
hormones
have
roles
etiopathogenesis
adolescent
females.
Language: Английский