Risk of falls in patients with arthritis: results from the China Health and Retirement Longitudinal Study (CHARLS) DOI Creative Commons

zhongci Zhong,

Jiayi Chen,

Chenfeng Hua

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Background Arthritis is a common chronic disease often accompanied by pain and activity limitation, which significantly affects the quality of life older adults may increase risk falls. This study aimed to clarify association between arthritis fall its influencing factors. Methods Data from China Health Retirement Longitudinal Study (CHARLS) were compared participants with without arthritis. The effect on incidence falls was assessed propensity score matching (PSM) method, adjusting for potential confounders, using multiple statistical models (e.g., multivariate logistic regression inverse probability weighting model) calculate odds ratio (OR) 95% confidence interval (95% CI). Results A total 9553 subjects included, overall 40.7%. data rate patients 25.6%, whereas in 22.0%. Multivariate analysis showed that 0.90 CI: 0.82 0.99, P = 0.042). Subgroup sensitivity analyses results stable reliable. Conclusions confirms significance suggests development prevention strategies improve their health outcomes.

Language: Английский

1,25(OH)2D3 induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway DOI
Pingping Liu, Junxian Zhou,

Haigang Cui

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
SUMOylated GLUT1 inhibited the glycometabolism disorder in chondroctyes during osteoarthritis DOI Creative Commons
Liwei Xiong

Glycoconjugate Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

0
Eficacia de la inyección intraarticular única de ácido hialurónico con una alta concentración para la osteoartritis de rodilla � 12 meses de seguimiento DOI
L. M. Torres,

Francesc Reina,

Jesús Ortega

et al.

Multidisciplinary Pain Journal, Journal Year: 2025, Volume and Issue: unknown, P. 2 - 10

Published: Jan. 1, 2025

Citations

0
Glucagon-like peptide-1 receptor agonists therapy to attenuate the risk of knee osteoarthritis and total knee replacement in type 2 diabetes mellitus: A nation-wide population-based cohort study DOI Creative Commons
Chih-Ping Lin, Chi‐Hsiang Chung,

Chieh-Hua Lu

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(6), P. e41243 - e41243

Published: Feb. 7, 2025

Type 2 diabetes mellitus (T2DM) is an independent risk factor of knee osteoarthritis (KOA). This study was mainly based on data from the Taiwan National Health Insurance Database. Using big analysis, we showed that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment helpful for patients with T2DM who have a lower KOA or total replacement (TKR). A 35,762 were included in this study. We divided these into 988 without and 372 received GLP-1RA those did not receive treatment. The matched sex, age, inclusion date by 1:1 propensity score, which control group. Cox proportional hazards analyses performed to compare TKR rate during maximum follow-up period 5 years. There 1976/744 without/with treatment, including 1052/322 men (53.24/43.28%) 924/422 women (46.76/56.72%). At end follow-up, there 46/39 (4.66/10.48%) underwent KOA/TKR than 87/70 (8.81/18.82%). hazard regression analysis among (adjusted ratio [HR] = .852; 95% confidence interval [CI] .784–.930, P < .001/ adjusted HR .913; CI .885–.977, .015, respectively). Kaplan–Meier cumulative patient with/without significantly different (log-rank test, .001, aimed provide clinicians option as reduce such patients.

Language: Английский

Citations

0
Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway DOI Creative Commons
Zhimeng Zhang,

Daotong Yuan,

Ximin Jin

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Asperosaponin VI (AVI) is a naturally occurring monosaccharide derived from Dipsacus asperoides renowned for its anti-inflammatory and bone-protective properties. Objective To elucidate the specific mechanism through which AVI affects chondrocytes in osteoarthritis (OA). Methods For vitro experiments, primary were to molecular mechanisms underlying action of AVI.For vivo rat OA models established using modified Hulth method. The severity knee was evaluated 8 weeks post-surgery. Micro-CT imaging, hematoxylin-eosin staining, Safranin O-fast green staining used assess degeneration joints. Immunohistochemistry techniques conducted measure levels collagen II, MMP13, Nrf2, GPX4, ACSL4, HO-1 within cartilage tissues. ELISA assays performed those TNF-α, IL -6, PGE2 serum samples. Results alleviated chondrocyte apoptosis extracellular matrix degradation induced by IL-1β. It attenuated IL-6, while reducing Fe 2+ malondialdehyde (MDA). upregulated expression HO-1, GPX4 downregulating that ACSL4. Mechanistic studies revealed ML385-induced inhibition Nrf2 signaling pathway reversed increase ACSL4 increased MDA levels; treatment with erastin, ferroptosis inducer, produced comparable results. In experiments demonstrated improved bone volume/tissue volume trabecular separation values rats; Osteoarthritis Research Society International score; expression; downregulated MMP13 expression, decreased PGE2. Conclusion Our findings suggest promising therapeutic agent OA. exerted protective effect regulating Nrf2/GPX4/HO-1 axis inhibit cell improve osteoarthritis.

Language: Английский

Citations

0
Exosomes in cartilage microenvironment regulation and cartilage repair DOI Creative Commons
Longfei Han,

Hou Wenyuan,

Weihua Fang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology defined by progressive degradation of articular cartilage, formation bone spurs, synovial inflammation, resulting in pain, joint function limitations, substantial societal familial burdens. Current treatment strategies primarily target pain alleviation, yet improved interventions addressing underlying are scarce. Recently, exosomes have emerged as subject growing interest OA therapy. Numerous studies investigated to offer promising therapeutic approaches for through diverse vivo vitro models, elucidating mechanisms which from various cell sources modulate cartilage microenvironment promote repair. Preclinical investigations demonstrated regulatory effects originating human cells, including mesenchymal stem cells (MSC), fibroblasts, chondrocytes, macrophages, derived Chinese herbal medicines, on modulation repair signaling pathways. Additionally, encompass matrix, proliferation migration autophagy, apoptosis, mitigation oxidative stress. An increasing number exosome carrier scaffolds under development. Our review adopts multidimensional approach enhance comprehension pivotal functions exerted sourced types OA. Ultimately, our aim pinpoint targets capable regulating facilitating

Language: Английский

Citations

0
Unraveling the Molecular Mechanisms of Osteoarthritis: The Potential of Polyphenols as Therapeutic Agents DOI Open Access
Syed Nasar Rahaman,

Murugesan Lishadevi,

Suresh Kumar Anandasadagopan

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

The complex nature of osteoarthritis (OA), driven by the intricate interplay genetic, environmental, and lifestyle factors, necessitates development a single treatment method, which is highly challenging. long-term use non-steroidal anti-inflammatory drugs (NSAIDs) corticosteroids often leads to adverse side effects like kidney damage stomach ulcers. Major health threats obesity aging create milieu chronic low-grade inflammation increased mechanical stress on joints resulting in cartilage deterioration. Additionally, postmenopausal women with lower circulating 17β-estradiol levels experience accelerated joint deterioration due immune activity production pro-inflammatory cytokines, elevated MMP expression decreased type II collagen synthesis. Polyphenols are nature's gifted magic molecules, possess diverse biological properties anti-oxidant, anti-bacterial, anti-inflammatory, estrogenic, insulin-sensitizing effects, can manage treat all multi-factorial contributing factors OA effectively. Certain polyphenols act as phytoestrogens mimic natural estrogen binding ERα ERβ SERMs prevent degradation articular thereby alleviating osteoarthritic conditions. These molecules downregulate various apoptotic genes, matrix-degrading proteases (MMPs) while upregulating major ECM proteins collagen, aggrecan, proteoglycans animal models. This review provides comprehensive overview molecular mechanisms involved also explores therapeutic potential different mitigating their protective effect inhibiting extracellular matrix (ECM) enhancing homeostasis.

Language: Английский

Citations

0
Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health DOI Creative Commons
Iryna Halabitska, Pavlo Petakh, Oleksandr Kamyshnyi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Background Osteoarthritis (OA) and impaired glucose tolerance (IGT) frequently coexist, leading to compounded clinical metabolic challenges. This study investigates the effects of metformin in improving both outcomes (pain, stiffness, physical function) parameters (inflammatory markers, lipid profile, BMI) patients with knee OA IGT. Methods The included 60 diagnosed Participants were divided into two groups: 26 received standard treatment without (Without Metf), while 34 (500 mg twice daily) for 3 months, addition (With Metf). Clinical assessments (WOMAC, Lequesne Algofunctional Index, KOOS, VAS) markers (CRP, NLR, SOD, measured before treatment, after 1 month, months. Results With Metf group showed significantly greater improvements pain, function, quality life compared Without group. Metformin also led significant reductions inflammatory profiles health indicators. demonstrated enhanced BMI, waist-to-hip ratio, waist-to-height ratio. Furthermore, need increased NSAID doses was predicted by factors such as pain severity markers. Conclusion effectively alleviates osteoarthritis symptoms improves Further research is needed explore its long-term on joint health, potential role management

Language: Английский

Citations

0
NOX1-mediated oxidative stress induces chondrocyte ferroptosis by inhibiting the Nrf2/HO-1 pathway DOI Creative Commons

Lin Tao,

Keda Yang, Ke Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 27, 2024

Osteoarthritis (OA) is a common joint disease associated with the aging of population, and it reduces quality life patients. It characterized by destruction articular cartilage secretion inflammatory cytokines. Owing to unclear pathogenesis OA, current treatment methods have significant limitations. Oxidative stress has been revealed play an important role in development OA. Our experiments indicated that levels GSH decreased level MDA increased chondrocytes, which induced ferroptosis chondrocytes We also was main mechanism caused addition activator erastin inhibitor ferrostatin-1. NOX1 modulator oxidative increasing generation reactive species (ROS). suppressed expression through cell transfection. The collagen II MMP13, IL-1β TNF-α were reversed. An increase mitochondrial membrane potential decrease intracellular ROS indicate improvement damage. Additionally, we determined effect Nrf2/HO-1 pathway on NOX1-mediated chondrocyte injury. found inhibited Nrf2/HO-1, but activation Nrf2 improved damage vivo vitro. This study induces inhibiting pathway. findings contribute revealing providing targets for drug design optimizing clinical

Language: Английский

Citations

3
Coenzyme-A-Responsive Nanogel-Coated Electrochemical Sensor for Osteoarthritis-Detection-Based Genetic Models DOI Creative Commons
Akhmad Irhas Robby, Songling Jiang, Eun‐Jung Jin

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 451 - 451

Published: July 10, 2024

An electrochemical sensor sensitive to coenzyme A (CoA) was designed using a CoA-responsive polyallylamine-manganese oxide-polymer dot nanogel coated on the electrode surface detect various genetic models of osteoarthritis (OA). The responded abundance CoA in OA, causing breakage MnO

Language: Английский

Citations

2