Therapeutic applications of natural products in the management of venous diseases: a comprehensive review

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract The occurrence of venous diseases among adults is approximately 77% in females and 57% males. These conditions are prevalent, progressive disorders that significantly affect individuals socially, physically, psychologically, often resulting various abnormalities hinder effective blood circulation the lower limbs. This review provides a comprehensive overview diseases, focusing on their pathophysiology, symptoms, causes, risk factors, diagnosis, complications. symptoms associated with diverse can include pain, heaviness, swelling, ulcers, skin changes. Risk factors such as age, obesity, hormonal influences, genetic predispositions discussed relation to contribution disease progression. therapeutic modalities for managing explored, particular emphasis natural products alleviating improving vascular health. Natural compounds, i.e., flavonoids, play vital role circulatory system, supporting vessels promoting healthy flow, addition vasoprotective, antioxidant, anti-inflammatory, anti-platelet properties. Overall, ongoing research efforts efficacy will enhance management several coming years.

Language: Английский

Flavonoids in Lotus Stamen Extract Inhibit High Glucose-Induced Intracellular Glycation in Fibroblasts by Upregulating the Expression of Glyoxalase 1 and Alleviating Oxidative Stress

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 392 - 392

Published: March 26, 2025

Glycation is a process in which reducing sugars bind to proteins, resulting the formation of advanced glycation end products (AGEs). These AGEs accumulate skin, promote excessive collagen crosslinking, and disrupt extracellular matrix (ECM), impairing normal cellular functions contributing skin aging. To evaluate anti-glycation efficacy lotus stamen extract (LSE), we employed BSA–fructose system high glucose (HG)-induced fibroblast model. The results demonstrated that LSE effectively inhibited also exhibited anti-inflammatory, antioxidative, anti-senescent effects HG-induced human fibroblasts (HSF). Further investigation into mechanism component analysis ethyl acetate (LSEE) led identification 15 flavonoids. indicated these flavonoids are likely primary active constituents LSE. Mechanistic studies revealed GLO1 plays crucial role resistance glycation, LSEE enhanced expression through Nrf2/Keap1 pro-survival pathway, thereby mitigating intracellular AGE production. In summary, its multiple flavonoid components exhibit potent activity present significant potential be developed as natural organic product for cosmetic healthcare applications.

Language: Английский

Investigation of Antifungal Susceptibility Profile in Fungi Isolated from Patients with Chronic Wounds: A Focus on Venous Ulcers

Journal of Advances in Medicine and Medical Research, Journal Year: 2024, Volume and Issue: 36(12), P. 225 - 230

Published: Dec. 14, 2024

Background: The complexity and challenges in managing patients with chronic wounds, combined high morbidity rates, make this condition a significant public health issue. polymicrobial presence of microorganisms, particularly fungi, these wounds poses major challenge for understanding the infectious process defining therapeutic approaches. Aims: This study investigated, over course one year, fungi 30 clinical samples collected from 10 caused by venous ulcers characterized susceptibility profile to antifungal agents amphotericin B fluconazole using microdilution method following EUCAST protocol. Results: We observed that 30% had positive fungal cultures, Candida tropicalis (67%) being most frequently isolated species, followed guilliermondii (33%). highest minimum inhibitory concentration (MIC) values were (4 mg/L), while (0.5 MIC did not differ significantly between species. Conclusion: Our findings indicate can be present ulcer may impair healing process. demonstrated persistent yeasts ulcers, suggesting they negatively impact Performing microbiological laboratory tests monitoring profiles are important implementing appropriate strategies aiding management patients.

Language: Английский