Brain aromatase dynamics reflect parental experience and behaviour in male mice DOI Creative Commons
Paula Duarte‐Guterman, Dimitri A. Skandalis,

Ariane Merkl

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 18, 2023

Abstract In most mammals, paternal care is not mandatory for raising offspring. house mice, experience with pups governs the extent and quality of care. First-time fathers undergo a dramatic transition from ignoring or killing to caring pups. The behavioral shift occurs together changes in brain estrogen signaling as indicated by receptor presence distribution multiple areas regulating olfaction, emotion, motivation. Here, we report expression aromatase, enzyme converting testosterone into estrogen, an indirect measure synthesis. amount (5 27 days) was associated increased numbers immunocytochemically-identified aromatase expressing cells medial cortical amygdala, posterior piriform cortex, ventromedial hypothalamus. Functionally, these can be related disappearance aggression neglect towards when first-time or, even more, well-experienced are handling their own lateral septum, anterior cortex some preoptic area, parental number aromatase-positive only days experience, right hemisphere. This new case brain-functional lateralization due that has activated certain instinctive behavior. Nuclei/areas maternal (medial bed nucleus stria terminalis, accumbens) exhibited left-hemisphere advantage cells, both pup-naïve pup-experienced males. newly found may contribute dominant processing perception pup calls release general, experience-dependent observed did mirror previously reported receptors (ERα) males became pup-caring fathers. Hence, behavior depend area-specific way on differential action through its and/or direct local modulation neural processing.

Language: Английский

Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice. DOI
Brigitta Bonaldo, Antonino Casile,

Martina Bettarelli

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120888 - 120888

Published: Jan. 1, 2025

Language: Английский

Citations

0
Brain aromatase and its relationship with parental experience and behavior in male mice DOI Creative Commons
Paula Duarte‐Guterman, Dimitri A. Skandalis,

Ariane Merkl

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 17, 2025

Introduction In most mammals, paternal care is not mandatory for raising offspring. house mice, experience with pups governs the extent and quality of care. First-time fathers undergo a dramatic transition from ignoring or killing to caring pups. The behavioral shift occurs together changes in brain estrogen signaling as indicated by receptor presence distribution multiple areas regulating olfaction, emotion, motivation. Methods We measured expression aromatase, enzyme converting testosterone into estrogen, an indirect measure synthesis, various limbic system mice increasing experience. Results amount (5 27 days) was associated increased numbers immunocytochemically-identified aromatase expressing cells medial cortical amygdala, posterior piriform cortex, ventromedial hypothalamus. Functionally, these can be related disappearance aggression neglect towards when first-time or, even more, well-experienced are handling their own lateral septum, anterior cortex some preoptic area, parental number aromatase-positive only days experience, right hemisphere. This represents novel case brain-functional lateralization triggered Nuclei/areas maternal (medial bed nucleus stria terminalis, accumbens) exhibited left-hemisphere advantage cells, both pup-naïve pup-experienced males. newly found may contribute dominant processing perception pup calls release behavior. Conclusion general, experience-dependent we observed did mirror previously reported receptors (ERα) males became pup-caring fathers. Hence, behavior depend, area-specific way, on differential action through its and/or direct local modulation neural processing.

Language: Английский

Citations

0
Effects of minipuberty disruption on the expression of sexual behavior in female mice DOI Creative Commons

Thomas Zurga Markus Torres,

Caroline Parmentier,

Céline J. Guigon

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Language: Английский

Citations

1
Brain aromatase dynamics reflect parental experience and behaviour in male mice DOI Creative Commons
Paula Duarte‐Guterman, Dimitri A. Skandalis,

Ariane Merkl

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 18, 2023

Abstract In most mammals, paternal care is not mandatory for raising offspring. house mice, experience with pups governs the extent and quality of care. First-time fathers undergo a dramatic transition from ignoring or killing to caring pups. The behavioral shift occurs together changes in brain estrogen signaling as indicated by receptor presence distribution multiple areas regulating olfaction, emotion, motivation. Here, we report expression aromatase, enzyme converting testosterone into estrogen, an indirect measure synthesis. amount (5 27 days) was associated increased numbers immunocytochemically-identified aromatase expressing cells medial cortical amygdala, posterior piriform cortex, ventromedial hypothalamus. Functionally, these can be related disappearance aggression neglect towards when first-time or, even more, well-experienced are handling their own lateral septum, anterior cortex some preoptic area, parental number aromatase-positive only days experience, right hemisphere. This new case brain-functional lateralization due that has activated certain instinctive behavior. Nuclei/areas maternal (medial bed nucleus stria terminalis, accumbens) exhibited left-hemisphere advantage cells, both pup-naïve pup-experienced males. newly found may contribute dominant processing perception pup calls release general, experience-dependent observed did mirror previously reported receptors (ERα) males became pup-caring fathers. Hence, behavior depend area-specific way on differential action through its and/or direct local modulation neural processing.

Language: Английский

Citations

0