Causal relationship between serum metabolites and idiopathic pulmonary fibrosis: insights from a two-sample Mendelian randomization study DOI Creative Commons

Qiong‐Chao Zou,

Jun-Pei Hu,

Yan Cao

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36125 - e36125

Published: Aug. 1, 2024

BackgroundIdiopathic pulmonary fibrosis (IPF) is an irreversible lung disease with unclear pathological mechanisms. In this study, we utilized bidirectional Mendelian randomization (MR) to analyze the relationship between serum metabolites and IPF, conducted metabolic pathway analysis.AimTo determine causal IPF using MR analysis.MethodsA two-sample analysis was evaluate 824 IPF. The inverse variance weighted (IVW) method used estimate exposure results. Sensitivity Egger, median, maximum likelihood eliminate pleiotropy. Additionally, identify potential pathways.ResultsWe identified 12 (6 risks 6 protective) associated from metabolites. Among them, 11 were known 1 unknown. 1-Eicosatrienoylglycophorophospholine 1-myristoylglycophorophospholine positive factors, being a risk factor (1.0013, 1.0097) 1-eicosatrienoylglycophorine protective (0.9914, 0.9990). four lipids (1-linoleoylglycerophoethanolamine*, total cholesterol in large high-density lipoprotein [HDL], esters very HDL, phospholipids HDL) one NA metabolite (degree of unsaturation) included hazardous three types (carnitine, 1-linoleoylglycerophoethanolamine*, 1-eicosatrienoylglycerophophophorine), amino acid (hypoxanthine), two unknown (the ratio omega-6 fatty acids omega-3 acids, photoshopids chylomicrons extremely low-density [VLDL]). Moreover, sn-Glycerol 3-phosphate 1-Acyl-sn-glycero-3-phosphocline found be involved pathogenesis through pathways such as Glycerolide metabolism Glycerophospholipid metabolism.ConclusionOur study 2 pathways, providing new perspective for further understanding

Language: Английский

Causal relationship between serum metabolites and idiopathic pulmonary fibrosis: insights from a two-sample Mendelian randomization study DOI Creative Commons

Qiong‐Chao Zou,

Jun-Pei Hu,

Yan Cao

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36125 - e36125

Published: Aug. 1, 2024

BackgroundIdiopathic pulmonary fibrosis (IPF) is an irreversible lung disease with unclear pathological mechanisms. In this study, we utilized bidirectional Mendelian randomization (MR) to analyze the relationship between serum metabolites and IPF, conducted metabolic pathway analysis.AimTo determine causal IPF using MR analysis.MethodsA two-sample analysis was evaluate 824 IPF. The inverse variance weighted (IVW) method used estimate exposure results. Sensitivity Egger, median, maximum likelihood eliminate pleiotropy. Additionally, identify potential pathways.ResultsWe identified 12 (6 risks 6 protective) associated from metabolites. Among them, 11 were known 1 unknown. 1-Eicosatrienoylglycophorophospholine 1-myristoylglycophorophospholine positive factors, being a risk factor (1.0013, 1.0097) 1-eicosatrienoylglycophorine protective (0.9914, 0.9990). four lipids (1-linoleoylglycerophoethanolamine*, total cholesterol in large high-density lipoprotein [HDL], esters very HDL, phospholipids HDL) one NA metabolite (degree of unsaturation) included hazardous three types (carnitine, 1-linoleoylglycerophoethanolamine*, 1-eicosatrienoylglycerophophophorine), amino acid (hypoxanthine), two unknown (the ratio omega-6 fatty acids omega-3 acids, photoshopids chylomicrons extremely low-density [VLDL]). Moreover, sn-Glycerol 3-phosphate 1-Acyl-sn-glycero-3-phosphocline found be involved pathogenesis through pathways such as Glycerolide metabolism Glycerophospholipid metabolism.ConclusionOur study 2 pathways, providing new perspective for further understanding

Language: Английский

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