Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons
Myrsini Orfanidou, Stergios A. Pοlyzos

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 38 - 38

Published: Dec. 30, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease, i.e., influencing various organ systems beyond the and, thus, contributing to comorbidities. Characterized by excessive fat accumulation in hepatocytes, MASLD frequently linked metabolic syndrome components, such as obesity, insulin resistance, dyslipidemia, and hypertension. Therefore, exploring intricate connection between other systems, including eyes, seems be essential. In this context, retinopathy has been investigated for its potential association with MASLD, since both conditions share common pathogenetic pathways. Chronic low-grade inflammation, oxidative stress, endothelial dysfunction are only some of those mechanisms progression possibly, determining bidirectional interplay retinal pathology. This narrative review aims summarize data concerning multisystemicity primarily focusing on eyes particularly, retinopathy. Identifying possible may emphasize need early screening integrated management approaches that address interconnected components within framework systemic disease. Further research necessary delineate precise develop targeted interventions mitigate impact aiming reduce overall burden improve patient outcomes.

Language: Английский

Elevated Triglyceride-Glucose Index as a Risk Stratification Marker for Diabetic Retinopathy in Type 2 Diabetes Mellitus: The Influence of Glycemic Control DOI Creative Commons
Xiaohua Wan, Ruihuan Zhang,

Adilan Abudukeranmu

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 743 - 759

Published: March 1, 2025

Background: Diabetic retinopathy (DR) is a common microvascular complication observed in people with type 2 diabetes mellitus (T2DM). The triglyceride-glucose (TyG) index, an indicator of insulin resistance, has uncertain role glycemic management T2DM patients at risk for DR. This study aimed to evaluate the association between TyG index and DR across different control status. Methods: A total 4,372 in-patients from Beijing Tongren Hospital (2013– 2024) were included this study. categorized into four groups based on quartiles (Q1-Q4). Participants stratified by (Q1-Q4) status (HbA1c < 7%, 7– 9%, > 9%). Restricted cubic spline (RCS) analysis, logistic regression, subgroup analyses employed explore associations among risk. Results: Overall, there positive highest Q4 was significantly associated increased (odds ratio [OR]: 1.289; 95% confidence interval [CI]: 1.008– 1.648, P 0.05), compared lowest Q1. Significant interaction ( 0.05). Notably, strongest HbA1c 9%. Conclusion: relationship high more pronounced 9% group, indicating that may serve as useful tool making stratification patients. Keywords: retinopathy, control, glycated hemoglobin A1c,

Language: Английский

Citations

0
The potential role of adipokines and hepatokines in age-related ocular diseases DOI Creative Commons
Stavroula Almpanidou, Ilias D. Vachliotis, Antonis Goulas

et al.

Metabolism Open, Journal Year: 2025, Volume and Issue: unknown, P. 100365 - 100365

Published: April 1, 2025

Age-related ocular diseases, including diabetic retinopathy (DR), age-related macular degeneration (AMD), cataract and glaucoma may lead to visual impairment even blindness. Metabolic such as obesity metabolic dysfunction-associated steatotic liver disease (MASLD) have emerged potential risk factors of especially DR. Visceral adiposity has been associated with increased DR AMD in most clinical studies, although body mass index to-date provided conflicting association AMD. In addition, is recognized a factor glaucoma. Similarly obesity, MASLD appears be patients type 1 diabetes mellitus, but probably not those 2 mellitus. A positive between AMD, supported by limited evidence to-date, thus needing further investigation. Altered secretion patterns adipokines (adiponectin, leptin, lipocalin-2, resistin) hepatokines [adropin, fetuin-A, fibroblast growth (FGF)-21, retinol binding protein (RBP)-4] seem disrupt homeostasis contribute the development diseases context MASLD. this regard, novel adipokine-based hepatokine-based therapies added treatment options for future. This narrative review aimed summarize on interconnection specific focus roles mediators these associations.

Language: Английский

Citations

0
The association between urinary caffeine and caffeine metabolites and diabetic retinopathy in individuals with diabetes: NHANES 2009–2014 DOI Creative Commons
Xiaohong Chen, Qianwen Guo, Jiarui Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 6, 2025

The association between caffeine and diabetic retinopathy (DR) risk remains controversial. This study aims to examine the urinary metabolites self-reported DR in US individuals with diabetes. cross-sectional enrolled 535 participants diabetes from National Health Nutrition Examination Survey (NHANES) 2009-2014. high-performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry (HPLC-ESI-MS/MS) internal standards labeled stable isotopes were used measure fourteen of its metabolites. Urinary levels calibrated urine creatinine for analysis. Caffeine analyzed as continuous variables categorical (≤ 50% or > 50%). Weighted logistic regression models calculate odds ratios (OR) 95% confidence intervals (CI). Subgroup analysis by sex was conducted. After adjusting age, sex, race, BMI, smoking, alcohol drinking, duration diabetes, glycated hemoglobin, hypertension, total energy intake, ln-transformed 1-methyluric acid (1-MU) (OR = 1.27, CI, 1.05 1.56, P 0.016) 5-acetylamino-6-amino-3-methyluracil (AAMU) 1.16, 1.01 1.34, 0.043) associated an increased risk. In median analysis, compared lower 50%), higher (> 50%) 1,7-dimethyluric (1,7-DMU) 1.92, 1.20 3.09, 0.008), 2.00, 1.27 3.16, 0.004), AAMU 1.48, 1.04 2.10, 0.029) Sex-based showed that 1-MU 1.10 1.98, 0.012), 1,3,7-TMU 1.24, 1.49, 0.018) 1.29, 1.03 1.60, 0.028) males. Compared 1,7-DMU 2.75, 1.33 5.70, 2.26, 1.02 5.01, 0.044), 3.23, 1.53 6.82, 0.003), 2.93, 1.16 7.40, 0.024) indicated high 1-MU, 1,7-DMU, 1,3,7-TMU, males DM. Prospective studies are needed verify these findings.

Language: Английский

Citations

0
Correlation Between Triglyceride‐Glucose Index and Microvascular Complications in Patients With Early‐ Onset of Type 2 Diabetes Mellitus DOI Creative Commons
Liu Ran, Yang Han, Zhaohu Hao

et al.

Endocrinology Diabetes & Metabolism, Journal Year: 2025, Volume and Issue: 8(2)

Published: Feb. 13, 2025

ABSTRACT Objective This study aimed to explore the potential correlation between triglyceride‐glucose (TyG) index and diabetic nephropathy (DN) retinopathy (DR) in patients with early‐onset type 2 diabetes mellitus (T2DM). Design cross‐sectional statistically analysed TyG levels across DN DR stages non‐early‐onset T2DM. Patients A total of 1530 T2DM were enrolled January 2017 August 2023 at Tianjin Fourth Central Hospital Tianjin. Measurements Correlation analysis logistic regression used examine association microvascular complications. Kaplan–Meier plots Cox analyses employed evaluate effects on incidence. index's diagnostic ability for was explored using area under receiver operating characteristic curve. Results In T2DM, gradually decreased aggravation increased aggravation, showing a negative positive T2DM; suggested that an independent risk factor (OR = 1.623, 95% CI 1.175–2.242). The higher associated earlier incidence Conclusion could be complications, elevated potentially indicating high insulin– resistance related renal injury.

Language: Английский

Citations

0
Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons
Myrsini Orfanidou, Stergios A. Pοlyzos

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 38 - 38

Published: Dec. 30, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease, i.e., influencing various organ systems beyond the and, thus, contributing to comorbidities. Characterized by excessive fat accumulation in hepatocytes, MASLD frequently linked metabolic syndrome components, such as obesity, insulin resistance, dyslipidemia, and hypertension. Therefore, exploring intricate connection between other systems, including eyes, seems be essential. In this context, retinopathy has been investigated for its potential association with MASLD, since both conditions share common pathogenetic pathways. Chronic low-grade inflammation, oxidative stress, endothelial dysfunction are only some of those mechanisms progression possibly, determining bidirectional interplay retinal pathology. This narrative review aims summarize data concerning multisystemicity primarily focusing on eyes particularly, retinopathy. Identifying possible may emphasize need early screening integrated management approaches that address interconnected components within framework systemic disease. Further research necessary delineate precise develop targeted interventions mitigate impact aiming reduce overall burden improve patient outcomes.

Language: Английский

Citations

2