Cardiometabolic index as a predictor of gallstone incidence in U.S. adults: insights from NHANES 2017–2020

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 29, 2025

Gallstone disease (GSD) is associated with obesity. The Cardiometabolic Index (CMI), a metric that accurately assesses central adiposity and visceral fat, has not been extensively studied in relation to GSD risk. This study investigates the link between CMI incidence U.S. adults. utilized data from National Health Nutrition Examination Survey(NHANES)(2017-2020) assess association GSD, adjusting for confounders such as age, sex, race, chronic diseases, lifestyle factors. Multivariable logistic regression models subgroup analyses were employed. Generalized Additive Models (GAM) advanced curve fitting techniques used explore potential non-linear relationships, threshold effects determined via piecewise linear if relationships identified. Receiver Operating Characteristic (ROC) curves evaluated compared predictive performance of CMI, Body Mass (BMI), Waist Circumference (WC), establishing optimal cutoff values along their sensitivity specificity. included 3,706 participants, whom 10.6% (392) had GSD. Participants showed significantly higher (0.57 vs. 0.44, P = 0.0002). group more females older adults, increased risks hypertension, diabetes, serum cholesterol creatinine levels, risk cancer. Logistic analysis revealed was greater (OR 1.19, 95% CI 1.02-1.38, < 0.0001). ROC demonstrated superior (AUC 0.778), outperforming conventional metrics like BMI WC. GAM indicated positive correlation an 0.996. Subgroup found strongest among females, individuals aged 20-39, non-Hispanic Whites, those without history coronary heart disease, alcohol consumers. Our reveals nonlinear value Despite limitations sample size constrained fully adjusted model, after confounding factors, AUC predicting using reached 0.778, surpassing traditional metrics. These findings underscore importance critical factor emphasize necessity targeted interventions high-risk populations.

Language: Английский

Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Background Research indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, relationship between GHR and risk gallbladder stones remains unclear. This study investigates possible incidence stones. Methods research used information gathered from National Health Nutrition Examination Survey (NHANES) March 2017 2020. A calculation was made determine by dividing level HDL-C level. Several statistical methods, including analysis threshold effects, smoothed curve fitting, multiple logistic regression modeling, subgroup analysis, were utilized investigate connection gallstones. Results In 3898 U.S. adults, significantly positively associated with prevalence a fully adjusted model, increased 7% each 1-unit increase in (OR [95% Cl] = 1.07 [1.02, 1.14]). Compared members low group, those high group had 100% higher likelihood getting CI] 2.00 [1.31, 3.04]), this stabilizing always present different subgroups. With help smooth also showed there formed like an upside-down L shape The effect revealed inflection point 4.28. Conclusion results inverted L-shaped Keeping levels within certain range is lower gallstones general population.

Language: Английский

Association between the triglyceride-glucose obesity-related index and risk of gallstone disease and first gallstone surgery: the NHANES 2017-2020

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Background The triglyceride-glucose index (TyG) and its associated obesity indicators [TyG-body mass index(TyG-BMI), TyG-waist-height ratio(TyG-WHtR), TyG-waist circumference(TyG-WC)] are emerging tools for assessing insulin resistance. This study aimed to examine the association between TyG obesity-related risk of gallstone disease or first gallbladder surgery. Methods Individuals were selected from 2017–2020 National Health Nutrition Examination Survey (NHANES) database. associations TyG, TyG-WHtR, TyG-WC, TyG-BMI, surgery initially analyzed using weighted logistic regression models. Restricted cubic spline (RCS) plots receiver operating characteristic (ROC) curves used analyze relationship Generalized additive models, smoothed curve fitting, linear applied assess TyG-WC age at Sensitivity analyses, including stratified interaction conducted identify specific populations potential interactions covariates indicators. Mediation analyses explored role ethnicity as a mediator TyG-WHtR Results In this study, significantly correlated with surgery, except which showed no significant correlation. A was observed (P-overall < 0.0001, P-nonlinear > 0.05). addition, demonstrated strongest performance in predicting negatively (β = -0.03, 95% CI: -0.04, -0.01). analysis indicated that more strongly other races (OR 3.13, 1.67, 5.86). race mediated CONCLUSION TyG- WC, TyG-BMI linearly gallstones addition WC most favourable may lead an earlier attention needs be paid effect

Language: Английский