Associations between maternal microbiome, metabolome and incidence of low-birth weight in Guatemalan participants from the Women First Trial DOI Creative Commons
Meghan L. Ruebel, Stephanie P. Gilley, Laxmi Yeruva

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 15, 2024

Background Low birth weight (LBW; <2,500 g) affects approximately 15 to 20 percent of global births annually and is associated with suboptimal child development. Recent studies suggest a link between the maternal gut microbiome poor obstetric perinatal outcomes. The goal this study was examine relationships microbial taxa, fecal metabolites, anthropometry on incidence LBW in resource-limited settings. Methods This secondary analysis Women First trial conducted semi-rural region Guatemala. Maternal measured at 12 34 weeks (wk) gestation. Infant measures were collected within 48 h delivery. samples used for (16S rRNA gene amplicon sequencing) metabolomics (34 wk). Linear mixed models using MaAslin2 package utilized assess changes LBW. Predictive gradient boosted machines (XGBoost) developed H2o.ai engine. Results No differences β-diversity observed either time point mothers infants relative normal (NW) infants. Simpson diversity lower Notable genus-level abundance NW ( p < 0.05) increasing abundances Barnesiella , Faecalibacterium Sutterella Bacterioides . At weeks, there Magasphaera Phascolarctobacterium Turicibacter higher Bacteriodes Fusobacterium Fecal metabolites related bile acids, tryptophan metabolism fatty acid changed Classification predict based predicted functions showed moderate performance. Conclusion Collectively, findings indicate that alterations metabolome Future research should target functional predictive roles infant outcomes including birthweight.

Language: Английский

Associations between maternal microbiome, metabolome and incidence of low-birth weight in Guatemalan participants from the Women First Trial DOI Creative Commons
Meghan L. Ruebel, Stephanie P. Gilley, Laxmi Yeruva

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 15, 2024

Background Low birth weight (LBW; <2,500 g) affects approximately 15 to 20 percent of global births annually and is associated with suboptimal child development. Recent studies suggest a link between the maternal gut microbiome poor obstetric perinatal outcomes. The goal this study was examine relationships microbial taxa, fecal metabolites, anthropometry on incidence LBW in resource-limited settings. Methods This secondary analysis Women First trial conducted semi-rural region Guatemala. Maternal measured at 12 34 weeks (wk) gestation. Infant measures were collected within 48 h delivery. samples used for (16S rRNA gene amplicon sequencing) metabolomics (34 wk). Linear mixed models using MaAslin2 package utilized assess changes LBW. Predictive gradient boosted machines (XGBoost) developed H2o.ai engine. Results No differences β-diversity observed either time point mothers infants relative normal (NW) infants. Simpson diversity lower Notable genus-level abundance NW ( p < 0.05) increasing abundances Barnesiella , Faecalibacterium Sutterella Bacterioides . At weeks, there Magasphaera Phascolarctobacterium Turicibacter higher Bacteriodes Fusobacterium Fecal metabolites related bile acids, tryptophan metabolism fatty acid changed Classification predict based predicted functions showed moderate performance. Conclusion Collectively, findings indicate that alterations metabolome Future research should target functional predictive roles infant outcomes including birthweight.

Language: Английский

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