Published: Jan. 1, 2024
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 730 - 730
Published: March 17, 2025
Background: Epigenetic modifications have an important role in controlling ovarian function, modulating response and implantation success Assisted Reproductive Technologies (ART). The alterations, such as DNA methylation non-coding RNA control, been identified key variables regulating physiology reproductive outcomes. This systematic review investigates the significance of epigenetic pathways with emphasis on their effect ART rates. Methods: A thorough search PubMed, Scopus, EMBASE databases was performed to find articles published between 2015 2024 that investigated connection changes function patients. Studies examined miRNA expression, methylation, histone follicular fluid, granulosa cells, embryos were included. study followed PRISMA recommendations guarantee scientific rigor repeatability. data combined into a markers linked aging, reserve, success. Results: total 15 studies satisfied inclusion criteria, substantial relationships found distinct function. Changes expression patterns fluid cells associated oocyte maturation, potential. Women low reserve polycystic ovary syndrome (PCOS) different patterns. MiR-27a-3p miR-15a-5p shown be involved cell malfunction poor response, whereas global hypomethylation aging results. Conclusions: alterations affect via control hormone signaling, development, Further is needed determine practical applicability biomarkers predicting effectiveness enhancing patient treatment procedures.
Language: Английский
Citations
1
Theriogenology, Journal Year: 2025, Volume and Issue: 239, P. 117384 - 117384
Published: March 10, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0