Autoimmune Pancreatitis Mimicking a Pancreatic Neuroendocrine Tumor: A Case Report with a Literature Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1536 - 1536

Published: Feb. 12, 2025

Autoimmune pancreatitis (AIP) is a rare chronic subtype that often mimics pancreatic cancer due to the overlapping clinical and radiological features, posing significant diagnostic challenges. Similarly, distinguishing AIP from neuroendocrine neoplasms (PanNENs), which present with nonspecific symptoms, adds complexity evaluations. We case of 46-year-old male recurrent acute idiopathic pancreatitis. Abdominal computed tomography (CT) revealed 25 mm hypodense mass in tail mild arterial contrast enhancement. Magnetic resonance imaging (MRI) showed be hypointense on T2-weighted sequences, no diffusion restriction an enhancement pattern akin normal tissue. The endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) was inconclusive. Gallium-68 DOTATATE positron emission tomography-CT (Ga-68 PET-CT) increased tracer uptake, leading distal pancreatectomy splenectomy. Histopathology demonstrated sclerotic inflammatory infiltrates. Elevated serum IgG4 levels confirmed diagnosis type 1 Differentiating malignancies, including PanNENs, both critical complex. This highlights misdiagnosis PanNENs patient focal AIP, where hyperplasia islet cell clusters within fibrotic areas mimicked even Ga-68 PET-CT. findings emphasize potential for false positives PET-CT importance integrating clinical, radiological, histological data accurate diagnosis.

Language: Английский

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Molecular Classification and Characterization of Noninsulinoma: Ready for Prime Time in Clinical Practice?

International Journal of Surgical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Pancreatic neuroendocrine tumors are a heterogeneous group of rare clinical tumors, which can be classified into functional pancreatic tumor (insulinoma is the most common) and noninsulinoma. Insulinoma noninsulinoma have different mutation profiles. In noninsulinoma, ATRX/DAXX associated with alternative lengthening telomeres-positive phenotype positively correlated poor prognosis. Copy number variation also prognostic marker for high risk recurrence. Scholars used epigenetics as well multiomics approach (combining epigenetics, metabolomics, proteomics, etc) to molecularly type there huge differences in molecular expression patient prognosis between groups. this manuscript, we summarize published studies that utilized genome, epigenome, transcriptome, proteome data classify

Language: Английский

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Gastrointestinal neuroendocrine tumor syndromes (GI-NETS)

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

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Octreotide modified self-assembly Chlorin e6 nanoparticles with redox responsivity and active targeting for highly selective pancreatic neuroendocrine neoplasms photodynamic therapy

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112303 - 112303

Published: Nov. 1, 2024

Language: Английский

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