Serum uric acid to serum creatinine ratio and gallstones risk: Analysis from the National Health and Nutrition Examination Survey (2017–2020)
Abstract
Background
Insulin
resistance
and
metabolic
syndrome
had
a
significant
impact
on
the
development
of
gallstones.
This
study
investigated
relationship
between
gallstone
patients
in
United
States
serum
uric
acid
to
creatinine
ratio
(SUA/SCR).
Methods
In
this
study,
cross-sectional
analysis
was
conducted
with
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2017
2020.
The
SUA/SCR
functioned
as
standalone
predictor,
gallstones
prevalence
deemed
outcome
variable
significance.
We
utilized
multivariate
logistic
regression
model
assess
these
independent
dependent
variables.
A
restricted
cubic
spline
(RCS)
executed
evaluate
potential
non-linear
relationships.
cases
where
relationships
were
observed,
recursive
algorithms
employed
identify
inflection
points.
Likelihood
ratios
used
threshold
effect.
end,
stratified
analyses
determine
particular
demographics
showing
enhanced
proneness
prevalence.
Results
7,335
participants
analyzed
research,
including
777
who
self-reported
substantial
difference
noted
when
divided
into
those
without
fully
adjusted
multivariable
results
demonstrated
an
apparent
positive
association
likelihood
(OR
=
1.10,
95%
CI:
1.04,
1.16;
P
0.007).
addition,
connection
detected
(log-likelihood
p
<
0.01),
ideal
point
for
calculated
at
5.78.
subgroup
analysis,
notably
pronounced
among
white
Americans
under
age
60,
diabetes,
hypertension,
female
participants.
Conclusion
positively
correlated
higher
probability
occurrence
Americans.
It
could
function
practical
budget-friendly
tool
initially
detecting
individuals
predisposed
provided
valuable
insights
developing
preventive
strategies
interventions
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: May 7, 2025
Language: Английский