Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Junjie Wang, Xiaohong Chen,

Yirong Zhang

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), is one of the most common chronic diseases, which encompasses a spectrum from metabolic (MASL) to steatohepatitis (MASH), and may ultimately progress MASH-related cirrhosis hepatocellular carcinoma (HCC). MASLD complex that influenced by genetic environmental factors. Dysregulation hepatic lipid metabolism plays crucial role in development progression MASLD. Therefore, focus this review discuss links between variants DNA methylation metabolism-related genes pathogenesis. We first summarize interplay disturbance metabolism. Next, we on reviewing related gene loci onset existing literature around single nucleotide polymorphisms (SNPs) associated with identified genome-wide association studies (GWAS) candidate analyses. Moreover, based recent evidence human animal studies, further discussed regulatory function mechanisms changes levels occurrence MASLD, particular emphasis its MASH. Furthermore, alterations blood MASH patients. Finally, introduce potential value profiles developing novel prognostic biomarkers therapeutic targets for intending provide references future

Language: Английский

Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Junjie Wang, Xiaohong Chen,

Yirong Zhang

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), is one of the most common chronic diseases, which encompasses a spectrum from metabolic (MASL) to steatohepatitis (MASH), and may ultimately progress MASH-related cirrhosis hepatocellular carcinoma (HCC). MASLD complex that influenced by genetic environmental factors. Dysregulation hepatic lipid metabolism plays crucial role in development progression MASLD. Therefore, focus this review discuss links between variants DNA methylation metabolism-related genes pathogenesis. We first summarize interplay disturbance metabolism. Next, we on reviewing related gene loci onset existing literature around single nucleotide polymorphisms (SNPs) associated with identified genome-wide association studies (GWAS) candidate analyses. Moreover, based recent evidence human animal studies, further discussed regulatory function mechanisms changes levels occurrence MASLD, particular emphasis its MASH. Furthermore, alterations blood MASH patients. Finally, introduce potential value profiles developing novel prognostic biomarkers therapeutic targets for intending provide references future

Language: Английский

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