Emergence, Transmission, and Containment of Candida auris in the Perioperative Setting

AORN Journal, Journal Year: 2025, Volume and Issue: 121(2), P. 140 - 150

Published: Jan. 29, 2025

ABSTRACT Candida auris is an emerging, multidrug‐resistant fungus that poses a threat in health care settings because of its persistence on surfaces and ability to cause severe infections, particularly immunocompromised patients. First identified Japan 2009, C has since spread globally, leading numerous outbreaks. Its unique virulence factors, such as biofilm formation immune evasion, contribute resilience resistance eradication. The most vulnerable populations include those with underlying conditions undergoing operative or other invasive procedures, highlighting the importance this topic for perioperative personnel. Effective infection prevention strategies, including strict hand hygiene, environmental cleaning, use appropriate personal protective equipment, are essential prevent . Early detection, accurate identification, prompt isolation infected patients critical mitigating Continued research education vital developing more effective treatment protocols.

Language: Английский

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A systematic review on the anti-microbial activities and structure-activity relationship (SAR) of quinoxaline derivatives

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117472 - 117472

Published: March 3, 2025

Language: Английский

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Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments

Oriental Journal Of Chemistry, Journal Year: 2024, Volume and Issue: 40(3), P. 630 - 645

Published: June 27, 2024

Fungi occurred naturally like Candida yeast, in the human body. It may grow on skin, inside digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth. According their mode of action they divided into azoles (inhibit ergosterol synthesis), echinocandins (damage cell walls), polyenes (destroy cells) etc. Depending seriousness infection type infection, generally antifungal administered a Oral antifungals taken by mouth for systemic infections. Topical (creams, ointments) treat localized skin nail Intravenous (IV) administration is severe cases. Common side effects yeast hepatotoxicity, ringworm, infections Serious pose growing threat health specially vulnerable patients having significant morbidity mortality such as AIDS patients, transplant recipients, individuals using certain medications. Some existing drugs, particularly azoles, facing increasing resistance. In order ensure successful treatment these drug-resistant infections, there critical need development novel agents which very challenging. Here about antifungals, its classification, pros cons prevention control discussed detail.

Language: Английский

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Fungi that are medically relevant to humans and their prospect in a global warming scenario

Academia molecular biology and genomics., Journal Year: 2024, Volume and Issue: 1(1)

Published: Nov. 12, 2024

Language: Английский

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