The conserved cellular roles of CLN proteins: Novel insights from Dictyostelium discoideum

European Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 102(2), P. 151305 - 151305

Published: March 9, 2023

The neuronal ceroid lipofuscinoses (NCLs), collectively referred to as Batten disease, are a group of fatal neurodegenerative disorders that primarily affect children. etiology disease is linked mutations in 13 genes encode distinct CLN proteins, whose functions have yet be fully elucidated. social amoeba Dictyostelium discoideum has been adopted an efficient and powerful model system for studying the diverse cellular roles proteins. genome D. encodes several homologs human growing body literature supports conserved networking proteins humans. In humans, related autophagy, signal transduction, lipid homeostasis, lysosomal ion intracellular trafficking. Recent work also indicates play important role protein secretion. Remarkably, many these findings found parallels studies with discoideum. Accordingly, this review will highlight translatable value novel field NCL research propose further avenues using biomedical organism NCLs.

Language: Английский

Assaying Lysosomal Enzyme Activity in Dictyostelium discoideum

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 55 - 79

Published: Jan. 1, 2024

Language: Английский