Case Reports in Women s Health, Journal Year: 2023, Volume and Issue: 40, P. e00567 - e00567
Published: Nov. 22, 2023
Language: Английский
The Hastings Center Report, Journal Year: 2023, Volume and Issue: 53(S1)
Published: March 1, 2023
Abstract In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount often‐ugly history scientific attempts to understand genetic contributions human behaviors outcomes. They then describe what current science—including genomewide association studies polygenic indexes—can cannot tell us, as well its risks potential benefits. conclude with discussion responsible behavior in context SBG research. research that compares individuals within according “sensitive” phenotype requires extra attention communication findings. (1) on sensitive phenotypes (2) two or more groups defined (a) race, (b) ethnicity, (c) ancestry (where could easily be misunderstood race ethnicity) compelling justification conducted, funded, published. All agree at least convincing argument study's design yield scientifically valid results; some would additionally require study have socially favorable risk‐benefit profile .
Language: Английский
Citations
41
The American Journal of Human Genetics, Journal Year: 2022, Volume and Issue: 109(12), P. 2110 - 2125
Published: Nov. 17, 2022
Language: Английский
Citations
27
European Journal of Human Genetics, Journal Year: 2024, Volume and Issue: 32(6), P. 725 - 730
Published: Feb. 15, 2024
Abstract This study investigates changes in the social valuation of human genome over more than 30 years since establishment Human Genome Project. It offers a descriptive sociological analysis three waves this valuation, mainly by considering key UNESCO declarations and relevant report. These represent shifting balance between collectivism individualism, starting with broadly constructed as common heritage moving toward dynamic applications within various medical contexts (e.g., personalized genomic medicine editing). We seek to broaden analytical perspective examining how declarations’ ethical foci are framed context rapidly evolving genetic technologies their applications. conclude discussing continuity change value balancing vis-à-vis changing technologies.
Language: Английский
Citations
5
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(48)
Published: Nov. 18, 2024
Quantitative studies of cultural evolution and gene-culture coevolution (henceforth “CE” “GCC”) emerged in the 1970s, aftermath “race intelligence quotient (IQ)” “human sociobiology” debates, as a counter to extreme hereditarian positions. These incorporated transmission its interaction with genetics contributing patterns human variation. Neither CE nor GCC results were consistent racist claims ubiquitous genetic differences between socially defined races. We summarize how data refute notion racial substructure for populations address naive interpretations race across biological sciences, including those related ancestry, health, intelligence, that help perpetuate ideas. A perspective can reductionist determinist while providing more inclusive multidisciplinary framework which interpret
Language: Английский
Citations
4
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 31, 2024
The field of environmental epigenetics is uniquely suited to investigate biologic mechanisms that have the potential link stressors health disparities. However, it common practice in basic epigenetic research treat race as a covariable large data analyses way can perpetuate harmful biases without providing any insight. In this article, we i) propose researchers open dialogue about how and why employed study designs think critically might biases; ii) call for interdisciplinary conversation collaboration between epigeneticists social scientists promote collection more detailed metrics, particularly institutional structural metrics such levels discrimination could improve our understanding individual outcomes; iii) encourage development standards practices full transparency methods, with regard race; iv) continue structures contribute biological disparities, particular focus on influence racism may driving these
Language: Английский
Citations
2
Social Science & Medicine, Journal Year: 2024, Volume and Issue: 346, P. 116737 - 116737
Published: Feb. 28, 2024
Despite overwhelming evidence to the contrary, concept of 'race' as a biological unit continues persist in various scientific disciplines, notably field medicine. This paper explores persistence 'race biology' medical research via examining select citational practices that have perpetuated this problematic concept. Citations serve cornerstone literature, signifying reliability and expert affirmation. By analyzing citation threads historical patterns, we aim shed light on creation perpetuation false truths their impact research, training, practice. We focus two prominent examples, eGFR Spirometry, trace key articles' histories, highlighting flawed support racial corrections assessments. The equation incorporates factor based erroneous belief Black individuals higher muscle mass than white individuals. Our analysis reveals cited sources for lack robust well-developed datasets. Similarly, Spirometry measurements incorporate correction factors, relying questionable dating back Civil War era. They play crucial role shaping theoretical positions validating data assumed knowledge. Evaluating articles consistently referenced over time can reveal how falsehoods assertions are constructed maintained fields. study underscores need critical examination urges shift toward more cautious approach when citing biology.' calls reevaluation pedagogical approaches assigned readings education prioritize an anti-racist perspective future endeavors.
Language: Английский
Citations
1
Nature Genetics, Journal Year: 2024, Volume and Issue: 56(10), P. 1985 - 1988
Published: Sept. 9, 2024
Language: Английский
Citations
1
Sport Ethics and Philosophy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15
Published: June 6, 2024
In this article, we tackle the epistemological and ethical issues related to use of race concepts in genomics sport performance sport-related concussion (SRC). first part show how concept is ubiquitous scientific literature, besides fact that 'race' as other analogous population descriptors like 'ancestry' 'continent' carry ancestral genetic heterogeneity therefore they cannot be used infer any kind or physiological property. Then, investigate question whether research focusing on racial categories race-specific genes risk health outcomes due repetitive head impacts (RHI) justified from an point view, arguing it not; evidence supporting existence variants determining elite athlete status a predisposition after SRC scarce, (e.g. African Black, Caucasian White, Asian, etc.) proxies for associated with status/a ill-conceived. second analyze main concerning reification genomics, also considering more general issue social impact framework explanation individual differences SRC.
Language: Английский
Citations
1
iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111067 - 111067
Published: Sept. 28, 2024
Language: Английский
Citations
0
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 3, 2024
Recent advances in transcriptomics research have uncovered heightened interferon (IFN) responses neurodegenerative diseases including Alzheimer's disease, primary tauopathy, Parkinson's TDP-43 proteinopathy, and related mouse models. Augmented IFN signaling is now relatively well established for microglia these contexts, but emerging work has highlighted a novel role IFN-responsive T cells the brain peripheral blood some types of neurodegeneration. These findings complement body literature implicating dysregulated neuropsychiatric disorders major depression post-traumatic stress disorder. In this review, we will characterize integrate our understanding discuss how sex ancestry modulate response, examine potential mechanistic explanations upregulation antiviral-like pathways seemingly non-viral neurological psychiatric disorders.
Language: Английский
Citations
0