International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142798 - 142798
Published: April 1, 2025
Language: Английский
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 21, 2024
Globally, people widely recognize cancer as one of the most lethal diseases due to its high mortality rates and lack effective treatment options. Ongoing research into therapies remains a critical area inquiry, holding significant social relevance. Currently used treatment, such chemotherapy, radiation, or surgery, often suffers from other problems like damaging side effects, inaccuracy, ability clear tumors. Conventional are usually imprecise ineffective develop resistance treatments recurs. Cancer patients need fresh innovative that can reduce effects while maximizing effectiveness. In recent decades several breakthroughs in these, areas medical research, have paved way for new avenues fighting including more focused alternatives. This study reviews exciting possibilities mesenchymal stem cells (MSCs), nanomaterials, microbial agents modern realm treatment. Nanoparticles (NPs) demonstrated surprisingly potential. They improve drug delivery systems (DDS) significantly, enhance imaging techniques remarkably, target selectively protecting healthy tissues. MSCs play double role tissue repair vehicle novel gene NPs loaded with therapeutic agents. Additionally, utilizing agents, particularly those involving bacteria, offer an inventive approach review investigates potential MSCs, addressing shortcomings conventional therapies. We will also discuss challenges limitations using these approaches.
Language: Английский
Citations
4
Plant Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 220, P. 109471 - 109471
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomimetics, Journal Year: 2025, Volume and Issue: 10(1), P. 25 - 25
Published: Jan. 3, 2025
Meningitis is the acute or chronic inflammation of protective membranes, surrounding brain and spinal cord, this inflammatory process spreads throughout subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting capacity crossing blood–brain barrier (BBB) to reach central nervous system (CNS). Hence, it imperative develop novel approaches that can overcome these constraints offer efficient therapy for meningitis. Nanoparticle (NP)-based therapeutic have potential address limitations such as penetrating BBB achieving targeted release specific cells tissues. This review highlights recent advancements nanotechnology-based approaches, functionalized polymeric nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, nanoemulsions, liposomes, transferosomes, metallic NPs treatment Recently, bionics has emerged next-generation technology development ideas from biological principles, structures, interactions neurological neuroinfectious diseases. Despite their potential, more studies are needed ensure safety efficacy NP-based systems focusing on critical aspects toxicity, immunogenicity, pharmacokinetics. Therefore, addresses current strategies innovative nanoparticle discusses future directions meningitis therapies.
Language: Английский
Citations
0
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
In the dynamic realm of translational nanorobotics, endeavor to develop nanorobots carrying therapeutics in rational vivo applications necessitates a profound understanding biological landscape human body and its complexity. Within this landscape, membranes stand as critical barriers successful delivery therapeutic cargo target site. Their crossing is not only challenge for nanorobotics but also pivotal criterion clinical success therapeutic-carrying nanorobots. Nevertheless, despite their urgency, strategies membrane remain relatively underrepresented scientific literature, signaling an opportunity further research innovation. This review focuses on with various propulsion mechanisms from chemical physical hybrid mechanisms, it identifies describes four essential that represent needed be crossed journey applications. First entry point into blood stream, which skin or mucosa intravenous injection; next exit bloodstream across endothelium site; cell through plasma and, finally, escape lysosome, otherwise destroys cargo. The discusses design challenges inherent translating nanorobot technologies real-world provides overview documented crossings. aim underscore need interdisciplinary collaborations between chemists, materials scientists biologists vital domain has potential revolutionize field precision medicine.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5214 - 5250
Published: Feb. 4, 2025
In light of the ongoing technological transformation, embracing advancements that foster shared benefits is essential. Nanorobots, a breakthrough within nanotechnology, have demonstrated significant potential in fields such as medicine, where diagnostic and therapeutic applications are primary focus areas. This review provides comprehensive overview robots, their evolving role medical applications, particularly highlighting use nanorobots. Various design strategies operational principles, including sensors, actuators, nanocontrollers, discussed based on prior research. Key nanorobot include biomedical imaging, biosensing, minimally invasive surgery, targeted drug delivery, each utilizing advanced actuation technologies to enhance precision. The paper further examines recent progress micro/nanorobot addresses important considerations for future, biocompatibility, control, navigation, targeting, safety, ethical implications. offers holistic perspective how nanorobots can reshape practices, paving way precision medicine improved patient outcomes.
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 264 - 264
Published: Feb. 10, 2025
Nanoparticles have been widely used in cancer diagnostics and treatment research due to their unique properties. Magnetic nanoparticles are popular imaging techniques ability alter the magnetization field around them. Plasmonic mainly applied treatments like photothermal therapy convert light into heat. While these among respective fields, magnetic–plasmonic core–shell (MPNPs) gained popularity recent years combined magnetic optical properties from core shell. MPNPs stood out theranostics as a multimodal platform capable of serving contrast agent for imaging, guidable drug carrier, causing cellular ablation through energy conversion. In this review, we summarize different most common synthesis approaches. We particularly discuss applications diagnosis based on mechanisms using particles. Lastly, look current challenges they face clinical future perspectives detection therapy.
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
One of the main issues with drug delivery system is delivering to specific target site anticipated concentration produce a desired therapeutic potential drug. The major drawbacks in conventional dosage forms are lack targeted delivery, selectivity, non-specific distribution, poor bioavailability, frequent regimen, side effects, first-pass metabolism, solubility for poorly soluble drugs, inability cross biological barriers, gastrointestinal irritation, interaction, and effectiveness. Recent advancements molecular pharmacology action sites particular diseases have made new revolution develop different novel systems. These systems significantly increase thus exploiting effect reducing accumulation drugs off site. Different include microemulsion microsphers; nanodrug nanoparticles, nanogels, nanoemulsion, nanosuspension, nanotubes, dendrimers; vesicular includes liposomes, lipospheres, niosomes, phytosomes, transfersomes, ethosomes, vesosomes, herbosomes, solid lipid so on. Parameters such as particle size, shape, solubility, surface morphology, charge, biocompatibility, biodegradability, release play significant role deliver concentration. This chapter outlines discovery molecule, development process, limitations form, current system, application nanoparticles disease diagnosis, treatment like cancer, regulatory challenges. Further artificial intelligence has been outlined future perspectives system.
Language: Английский
Citations
0
Molecular Therapy — Methods & Clinical Development, Journal Year: 2025, Volume and Issue: 33(1), P. 101436 - 101436
Published: Feb. 16, 2025
Lipid nanoparticles (LNPs) are now highly effective transporters of nucleic acids to the liver. This liver-specificity is largely due their association with certain serum proteins, most notably apolipoprotein E (ApoE), which directs them liver cells by binding low-density lipoprotein (LDL) receptors on hepatocytes. The liver's distinct anatomy, its various specialized cell types, also influences how LNPs taken up from circulation, cleared, and they in delivering treatments. In this review, we consider factors that facilitate LNP's targeting explore latest advances liver-targeted LNP technologies. Understanding targeted can help for design optimization nanoparticle-based therapies. Comprehension cellular interaction biodistribution not only leads better treatments diseases but delivers insight directing other tissues, potentially broadening range therapeutic applications.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 41 - 61
Published: Jan. 1, 2025
Language: Английский
Citations
0