Probiotics: a promising future in the treatment of ulcerative colitis?

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Dipeptidyl peptidase 4: A predictor of ferroptosis in ulcerative colitis

The Journal of Gene Medicine, Journal Year: 2024, Volume and Issue: 26(10)

Published: Sept. 29, 2024

Abstract Background With its rapidly increasing incidence and prevalence, ulcerative colitis (UC) has become a major global health challenge. Recent evidence suggests that ferroptosis plays significant role in the development of UC. However, relationship between progression UC needs to be extensively studied. Methods The differentially expressed genes patients were screened from GEO database. ferroptosis‐related obtained FErrDB GeneCards. subtypes identified with R package “CancerSubtype” evaluated consensus clustering (CC) identify gene expression patterns key detected qRT‐PCR, Western blot, immunohistochemistry vitro vivo models. Ferroptosis was western blotting on ferrotic‐associated proteins staining Fe 2+ commercial FerroOrange kits. Results Dipeptidyl peptidase 4 (DPP4), also known as CD26, is potential biomarker for patients. Transcriptome sequencing data showed positive correlation decreased DPP4 proinflammatory cytokines such TNF‐α, IL‐6, IL‐β, well immune cell infiltration colon tissues Furthermore, strongly associated biomarkers, particularly Subtype 2 Interestingly, our study found significantly reduced RSL3‐treated ferroptotic intestinal epithelial cells, more so than LPS‐treated Inhibition had impact biomarkers. Additionally, DSS‐treated mice, inhibitor Ferritin‐1 effectively counteracted effects DSS infiltration, length, expression. Conclusions can serve diagnosis management

Language: Английский

Epigenetic modifications of inflammation in spinal cord injury

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117306 - 117306

Published: Aug. 16, 2024

Language: Английский