The Impact of Immune System Aging on Infectious Diseases

Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 775 - 775

Published: April 11, 2024

Immune system aging is becoming a field of increasing public health interest because prolonged life expectancy, which not paralleled by an increase in expectancy. As age progresses, innate and adaptive immune systems undergo changes, are defined, respectively, as inflammaging senescence. A wealth available data demonstrates that these two conditions closely linked, leading to greater vulnerability elderly subjects viral, bacterial, opportunistic infections well lower post-vaccination protection. To face this novel scenario, in-depth assessment the players involved changing epidemiology demanded regarding individual concerted involvement cells mediators within endogenous exogenous factors co-morbidities. This review provides overall updated description changes affecting system, may be help understanding underlying mechanisms associated with main age-associated infectious diseases.

Language: Английский

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The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline

Published: Aug. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096

Published: Sept. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

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Tráfico leucocitario: mecanismos e impacto clínico

Medicine - Programa de Formación Médica Continuada Acreditado, Journal Year: 2025, Volume and Issue: 14(28), P. 1688 - 1697

Published: March 1, 2025

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Improving understanding of ferroptosis: molecular mechanisms, connection with cellular senescence and implications for aging

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39684 - e39684

Published: Oct. 24, 2024

Language: Английский

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Radiation-Induced Macrovessel/Microvessel Disease

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2024, Volume and Issue: 44(12), P. 2407 - 2415

Published: Oct. 24, 2024

Radiation therapy (RT) is a cornerstone in cancer treatment (used 50% of cases), yet challenges persist because damage to normal tissue through direct impact radiation or bystander effects inevitable. Injury macrovessels by RT manifests as obstructive disease, which akin atherosclerotic disease. Historically observed coronary arteries patients treated for breast and lymphoma, it also affects receiving contemporary lung chest cancers. Moreover, at various sites can lead peripheral vascular An aspect radiation-induced injury that has received little attention microvascular injury, typically results from the endothelium considered primary driver RT-induced toxicity skin, kidney, brain. This review delves into clinical manifestations signaling pathways, cellular targets affected preclinical models injury. The goal inspire development innovative strategies prevent RT-related cardiovascular

Language: Английский

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