Role of solute carrier transporters in ovarian cancer (Review) DOI Creative Commons
Barbara Quaresima, Stefania Scicchitano, Maria Concetta Faniello

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(2)

Published: Nov. 27, 2024

Solute carrier (SLC) transporters are involved in various biological processes associated with metabolic reprogramming and cancer, supporting the increased requirement of nutrients energy. Over past decade, there have been significant advancements understanding expression function SLCs ovarian cancer (OC). This gynecological condition has a high mortality rate limited treatment options; thus, early diagnosis remains target clinically. OC exhibits complexity heterogeneity, resulting different clinical characteristics, resistance to chemotherapy drugs poor prognosis. Additionally, pattern between healthy tumor tissue, consequently, their inhibition or activation could modify signaling pathways growth process, such as cell proliferation, apoptosis drug accumulation. The present review aims consolidate current data provide comprehensive potential importance OC. it seeks offer guidance for further research on utilizing prognostic biomarkers therapeutic targets.

Language: Английский

Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for LUAD patients by comprehensive multi-omics analysis DOI Creative Commons
Zhiwu Lin,

Jing Lv,

Chuanqiang Dai

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 11, 2025

Language: Английский

Citations

0
Comprehensive identification of a disulfidptosis-associated long non-coding RNA signature to predict the prognosis and treatment options in ovarian cancer DOI Creative Commons
Shouze Liu, Rulan Jiang, Xinxin Wang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

Distinguished from cuproptosis and ferroptosis, disulfidptosis has been described as a newly discovered form of non-programmed cell death tightly associated with glucose metabolism. However, the prognostic profile disulfidptosis-related lncRNAs (DRLRs) in ovarian cancer (OC) their biological mechanisms need to be further elucidated.

Language: Английский

Citations

1
The role of molecular subtypes and immune infiltration characteristics based on disulfidptosis-related genes in ovarian cancer DOI Creative Commons

Ruanruan Yang,

Yating Wang, Zhifu Wei

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 28, 2024

Ovarian cancer (OC) is the most fatal, gynecological malignancy. Compared with advanced ovarian cancer, 5 year survival rate of early significantly improved, and predicting detection diagnosis very important to improve prognosis OC. Recent research has found a new way cell death: disulfidptosis. Under glucose starvation, abnormal accumulation disulfide molecules such as Cystine in SLC7A11 overexpression cells induced stress trigger death. Studies disulfidptosis are still their infancy its role progression unclear. In this study, we used public database detect expression mutations disulfidptosis-related genes Cluster analysis was performed based on genes, differential were analyzed. A prognostic risk model constructed using three reasons for differences explored through immune infiltration drug sensitivity analysis. The characteristics transcriptome closely related OC patients. Finally, quantitative polymerase chain reaction (RT-qPCR) clinical samples.Our study establishes link between OC, providing ideas personalized precise treatment

Language: Английский

Citations

1
Role of solute carrier transporters in ovarian cancer (Review) DOI Creative Commons
Barbara Quaresima, Stefania Scicchitano, Maria Concetta Faniello

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(2)

Published: Nov. 27, 2024

Solute carrier (SLC) transporters are involved in various biological processes associated with metabolic reprogramming and cancer, supporting the increased requirement of nutrients energy. Over past decade, there have been significant advancements understanding expression function SLCs ovarian cancer (OC). This gynecological condition has a high mortality rate limited treatment options; thus, early diagnosis remains target clinically. OC exhibits complexity heterogeneity, resulting different clinical characteristics, resistance to chemotherapy drugs poor prognosis. Additionally, pattern between healthy tumor tissue, consequently, their inhibition or activation could modify signaling pathways growth process, such as cell proliferation, apoptosis drug accumulation. The present review aims consolidate current data provide comprehensive potential importance OC. it seeks offer guidance for further research on utilizing prognostic biomarkers therapeutic targets.

Language: Английский

Citations

1