Potential mechanisms of epigenetic regulation in diabetic retinopathy from the perspectives of multi-omics DOI Creative Commons
Xin Luo, Daxi Xue

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 14, 2025

Diabetic retinopathy (DR) is a significant complication of diabetes, with complex pathogenesis involving epigenetic modifications. This study aimed to explore the regulatory mechanisms contributing DR. DR-related data, including DNA methylation, mRNA, and miRNA expression datasets, were obtained from Gene Expression Omnibus database. Differential gene analysis was performed identify differentially methylated genes expressed mRNAs miRNAs. Cross-analysis established methylation-expression miRNA-mRNA networks. A comprehensive network constructed, identifying hub genes. The characteristics these in various immune cells examined using single-cell RNA sequencing. We identified 10,716 genes, 1,181 mRNAs, 615 miRNAs associated pathways such as TGF-beta ErbB signaling. linked related cellular senescence, adherents junctions, endocytosis. Five identified: TFRC, AP2M1, AP2A1, DAB2, PPP1CB. Single-cell sequencing revealed specific particular cells, highlighting their potential roles DR pathogenesis. constructed for key offering new insights into molecular underlying therapeutic targets diagnosis treatment.

Language: Английский

Narrative review of comprehensive management strategies for diabetic retinopathy: interdisciplinary approaches and future perspectives DOI Creative Commons
Xiaoting Pei, Zhijie Li

BMJ Public Health, Journal Year: 2025, Volume and Issue: 3(1), P. e001353 - e001353

Published: Jan. 1, 2025

This review examines the epidemiological trends, pathophysiologic mechanisms, and current future therapeutic strategies for diabetic retinopathy (DR), focusing on innovative management countermeasures in face of this global public health challenge. As number patients with diabetes continues to increase, DR, as one its major complications, poses a significant threat visual health. not only summarises latest advances personalised treatment emerging modalities (such anti-vascular endothelial growth factor therapy, laser treatment, surgical procedures cutting-edge gene stem cell therapies) but also emphasises revolutionary potential telemedicine technologies digital platforms improve DR screening adherence among people diabetes. We show how these technological innovations, especially resource-limited settings, can achieve early diagnosis effective thereby significantly reducing burden DR. In addition, article highlights critical role interdisciplinary teamwork optimising comprehensive involving close collaboration physicians, researchers, patient education specialists policy-makers, well importance implementing solutions through societal engagement policy support. By highlighting their specific impact improving practices, offers new perspectives goal promoting prevention, worldwide, prognosis enhancing quality life.

Language: Английский

Citations

0
Retinal physiology in metabolic syndrome DOI
David O. Garcia

Advances in genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications DOI Creative Commons
Emad Gamil Khidr,

Nourhan Ibrahim Morad,

Shymaa Hatem

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Abstract Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate the effectiveness of current treatment modalities. Studies have highlighted potential natural products via several beneficial effects including anti-inflammatory, antioxidant, anti-neovascular, anti-apoptotic properties. Flavonoids, saponins, saccharides, alkaloids exhibited various vivo vitro studies. However, clinical utilization these compounds is hindered by issues such as inadequate specificity, low bioavailability, toxicity. Therefore, there pressing need for rigorous studies to confirm efficacy preventing mitigating progression DR.

Language: Английский

Citations

0
Significance of Macrophage-Mediated Inflammatory Response in Ocular Inflammatory Complications DOI Creative Commons

Stacey J. McMahon,

T. D. Spector,

Kota V. Ramana

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 18, 2025

Immune cells such as macrophages play a significant role in ocular inflammation by activating or inhibiting several cellular pathways. Systemic infections and autoimmune diseases could activate releasing various pro-inflammatory cytokines, chemokines, growth factors, which reach the eyes through blood-retina barrier cause immune inflammatory responses. In addition, environmental pollutants, allergens, eye injuries also an response. Further, response generated recruit additional enhance The leads to tissue damage dysfunction affects vision. Macrophages are generally implicated clearance of pathogens debris, generate reactive oxygen species, initiate However, uncontrolled responses tissues, leading complications uveitis, scleritis, diabetic retinopathy, retinitis. Recent studies describe individual cytokines mediation specific diseases. this article, we discussed potential impact their mediated on development possible treatment strategies.

Language: Английский

Citations

0
Potential mechanisms of epigenetic regulation in diabetic retinopathy from the perspectives of multi-omics DOI Creative Commons
Xin Luo, Daxi Xue

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 14, 2025

Diabetic retinopathy (DR) is a significant complication of diabetes, with complex pathogenesis involving epigenetic modifications. This study aimed to explore the regulatory mechanisms contributing DR. DR-related data, including DNA methylation, mRNA, and miRNA expression datasets, were obtained from Gene Expression Omnibus database. Differential gene analysis was performed identify differentially methylated genes expressed mRNAs miRNAs. Cross-analysis established methylation-expression miRNA-mRNA networks. A comprehensive network constructed, identifying hub genes. The characteristics these in various immune cells examined using single-cell RNA sequencing. We identified 10,716 genes, 1,181 mRNAs, 615 miRNAs associated pathways such as TGF-beta ErbB signaling. linked related cellular senescence, adherents junctions, endocytosis. Five identified: TFRC, AP2M1, AP2A1, DAB2, PPP1CB. Single-cell sequencing revealed specific particular cells, highlighting their potential roles DR pathogenesis. constructed for key offering new insights into molecular underlying therapeutic targets diagnosis treatment.

Language: Английский

Citations

0