Whole-Genome Selective Scans Detect Genes Associated with Cashmere Traits and Climatic Adaptation in Cashmere Goats (Capra hircus) in China DOI Open Access

Hongying Dan,

Haian Zhong,

Zhanerke Akhatayeva

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 292 - 292

Published: Feb. 27, 2025

Background: Cashmere, valued for its exceptional softness and warmth, is a major focus in goat breeding due to high economic importance. However, the molecular mechanisms underlying cashmere production remain largely unknown, hindering efforts optimize yield quality. Additionally, domestic goats exhibit remarkable adaptability diverse climates, ranging from arid northern regions humid southern areas, yet genetic basis these adaptations poorly understood. Exploring factors driving climatic adaptation could provide crucial insights into trait evolution support development of strategies improved productivity resilience. Methods: We utilized whole-genome resequencing data 157 samples representing 14 populations analyze diversity between non-cashmere breeds. we conducted tests selective sweeps (i.e., pairwise FST, θπ XP-EHH) traits genome–environment association analysis XtX statistic), respectively. Results: identified strong signatures previous reports (e.g., AKT3, FOXP1, FGF5, TGFBR3) novel genes ZEB1, ZNRF3, MAPK8IP3, MAPK8IP2, AXIN1) associated with traits. Further gene annotation KEGG analyses showed that were be most probable accounting Also, detected some such as PDGFRB, PRDM8, SLC26A2, SCAMP1, EPHX1, CDC25A, POLK played critical roles local climate variation. Conclusions: Collectively, our results adaptation, also new markers improvement goats.

Language: Английский

Whole-Genome Selective Scans Detect Genes Associated with Cashmere Traits and Climatic Adaptation in Cashmere Goats (Capra hircus) in China DOI Open Access

Hongying Dan,

Haian Zhong,

Zhanerke Akhatayeva

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 292 - 292

Published: Feb. 27, 2025

Background: Cashmere, valued for its exceptional softness and warmth, is a major focus in goat breeding due to high economic importance. However, the molecular mechanisms underlying cashmere production remain largely unknown, hindering efforts optimize yield quality. Additionally, domestic goats exhibit remarkable adaptability diverse climates, ranging from arid northern regions humid southern areas, yet genetic basis these adaptations poorly understood. Exploring factors driving climatic adaptation could provide crucial insights into trait evolution support development of strategies improved productivity resilience. Methods: We utilized whole-genome resequencing data 157 samples representing 14 populations analyze diversity between non-cashmere breeds. we conducted tests selective sweeps (i.e., pairwise FST, θπ XP-EHH) traits genome–environment association analysis XtX statistic), respectively. Results: identified strong signatures previous reports (e.g., AKT3, FOXP1, FGF5, TGFBR3) novel genes ZEB1, ZNRF3, MAPK8IP3, MAPK8IP2, AXIN1) associated with traits. Further gene annotation KEGG analyses showed that were be most probable accounting Also, detected some such as PDGFRB, PRDM8, SLC26A2, SCAMP1, EPHX1, CDC25A, POLK played critical roles local climate variation. Conclusions: Collectively, our results adaptation, also new markers improvement goats.

Language: Английский

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